“nominally significant”

We finally ranked our nominally significant biomarkers by importance using a multivariable Bayesian approach [ 4 ].

Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations.

Nominally significant departures from neutrality were obtained in seven of the nine test statistics for the non-coding variants, although the SDHA coding region variation was also suggestive of an excess of variants in intermediate frequencies in the African American samples.

In the EM study, erenumab treatment was associated with nominally significant reductions in WMD compared to placebo as early as Week 1 and for all doses by Week 4; (LSM change from baseline [95% CI]) in the EM study: placebo (− 0.1 [− 0.3, 0.0]), 70 mg (− 0.3 [− 0.5, − 0.2]; p = 0.130) and 140 mg (− 0.6[− 0.7, − 0.4]; p < 0.001) for Week 1; placebo (− 0.4 [− 0.5, − 0.2]), 70 mg (− 0.6 [− 0.8, − 0.5]; p = 0.029) and 140 mg (− 0.6 [− 0.8, − 0.5]; p = 0.019) at Week 4.

When the serum UA levels in quartile categories at baseline were further adjusted, the associations of UA trajectories 2, 3, and 4 with MASLD risk remained significant in men, whereas the associations of UA trajectories 3 and 4 remained statistically and nominally significant in women, respectively (Supplementary Table S2 ).

We observed a nominally significant association between a metabolic feature annotated to PA(O-18:1/20:4) and incident dementia ( SI Appendix , Tables S5 and S6 ).

By contrast, no significant indirect effect was observed for HDL, whereas triglyceride showed a borderline pattern, with a nominally significant indirect effect but a non-significant mediation proportion.

All P values presented are two-tailed; values below 0.05 were considered nominally significant.

Meta‐analyses with genetically‐matched AoU participants yielded three (two novel) genome‐wide significant AD‐associated loci based on rare lead variants: rs374043832 ( RGS6/PSEN1 ), rs192423465 ( ASPSCR1 ), and rs935208076 ( GDAP2 ), which were nominally significant in AoU sub‐cohorts.

Although the association between PKDCC rs12996954 and RCTs was only nominally significant in the UK Biobank cohort, it was replicated in the KPNC cohort.

Overall, we acknowledge that the result of our novel association study is most likely inflated by type-I error, while the meta-analysis results do not provide nominally significant evidence for association.

Among the nominally significant findings, deoxycholate remained significant after Bonferroni correction.

We found a nominally significant association between negative symptoms of schizophrenia and SLC17A7 rs62126236.

The analogous association with genes whose protein products were identified as interacting with Ca v 2 (voltage-gated calcium channel) was nominally significant. 56 Overall, there was little evidence of association between genes differentially regulated by miR-137 at 24 h but relatively consistent associations with upregulation at 48 h.

The signal for height in B4GALNT3 (rs215226) was directionally consistent and nominally significant in AAAGC only.

Results Nominally significant associations between RP and four SNPs in NOS1 and one in CALCB were identified.

We do not consider nominally significant direct or indirect effects to be significant if there is not also a significant total effect, but all results are reported for completeness.

A nominally significant association between protein intake and vertebral BMAT was observed in women in the main analysis; however, this finding should be interpreted cautiously given the exploratory nature of analyses.

In ADIPOR2 a few SNPs showed nominally significant association with BMI and 2-h glucose levels.

[ 30 ] In terms of the significance of our findings, we considered the causal probability < 0.05 between exposure and outcome to be nominally significant if supported by at least 1 additional method. 2.5.

We found that none of the DHS samples in our dataset showed nominally significant enrichment.

There were nominally significant differences for two items from the PACIC subscale “Goal setting” (“I was given a copy of my treatment plan”, p-value: 0.027; “I was encouraged to go to a specific group or class to help me cope with my chronic condition”, 0.025) and for two items from the PACIC subscale “problem solving/contextual counselling” (“I was helped to make a treatment plan that I could carry out in my daily life”, 0.019; “I was helped to plan ahead so I could take care of my condition even in hard times”, 0.012).

S 3 for illustration purposes, and the ROIs showing nominally significant group differences and their corresponding Gordon networks are listed in Table S 1 .

A 2-sided p <0.05 was considered nominally significant with no adjustment for multiple testing.

Neither of these effects reached study-wide significance after correction for multiple comparisons using a permutation test. Additionally, we found nominally significant associations between several supplementary self-report measures and AVPR1A rs1042615 or OXTR rs237889 (see Supplementary Table 2 for the full results).