“nominally significant”

Out of these 40 target genes, 16 genes showed nominally significant differences in gene expression and were picked along with reference genes for the main experiment including 144 cases and 154 controls.

In contrast, the variants at TCF7L2 (rs7903146) and KCNQ1 (rs2237897) became nominally significant.

This analysis is intended to assess the robustness of nominally significant findings to multiplicity adjustment.

While the differential gene expression analysis did not yield any genes that passed a false discovery rate (FDR) threshold of 5%, a gene ontology analysis of the top nominally significant genes did show significant enrichment of terms related to immunological processes, metabolism, and synaptic transmission (Supplementary Fig.

For the hypertension complicating pregnancy, a trait highly phenotypically correlated to PE, we observed a nominally significant enrichment of the tight junction genes [KEGG], a pathway that we also identified to be enriched among GDM loci using the GWAS Catalog data.

To reduce the possibility of a single disease driving the cross‐disease associations and uncover truly pleiotropic genes shared by AD and IS, we focused on shared genes that were nominally significant in each disease ( P AD < 0.05 and P IS < 0.05). 2.2.2 Meta‐analysis using Fisher's method We used Fisher's method to combine the P ‐values calculated by the VEGAS2 for each gene shared by AD and IS.

The missense variants in PRAM1 and USH2A showed nominally significant association with MS in the exome chip study of the IMSGC [ 24 ].

Consequently, in women, the HTR2A rs6311 polymorphism exhibited a consistent and highly significant association with suicide attempts across all inheritance models, while the SKA2 rs7208505 polymorphism demonstrated a nominally significant sex-specific effect. 3.

In the gene‐based analysis, four candidate genes ( CDH1 ; Transmembrane Channel like 6 ( TMC6 [MIM:605828]; NM_001127198.5 ); Eukaryotic Translation Initiation Factor 3 Subunit G ( EIF3G [MIM:603913]; NM_003755.4 ); and TRMO ) showed a nominally significant enrichment for deleterious variants in the European patients ( p CDH1 = 0.0019, p TMC6 = 0.0132, p EIF3G = 0.0133, p TRMO = 0.0399) (Table S7 ).

Identification of differentially-expressed modules of genes in somatostatin-positive cells Although we detected some genes with altered expression in somatostatin-positive cells which were nominally significant, but did not meet the Benjamini Hochberg threshold for multiple testing.

When the P-value falls within the range of 0.017 and 0.05, it is categorized as nominally significant.

Higher order three way unadjusted MDR interactions were nominally significant only if the HNF4A SNP was one of the interacting SNPs.

Among the nominally significant loci, there are 16 regions that overlap with gene exons ( Table 3 ) which are very likely to have direct impact on the gene products.

At the uncorrected level, GCC average thickness ( p = 0.021), GCC GLV ( p = 0.027), RNFL average thickness ( p = 0.044), and ACD ( p = 0.031) showed nominally significant differences across age subgroups.

Both markers demonstrated nominally significant differential expression and consistent survival associations and were therefore prioritized to construct the two-marker ICP2 signature.

Nominally significant benefits in favor of abatacept + MTX were observed for all secondary endpoints.

In our study cohort, we observed a nominally significant correlation; however, this correlation appeared to be confounded by both the father’s age at conception (consanguineous couples in our cohort conceived earlier) and the availability of more siblings in consanguineous families (larger kindreds).

None of the dominance or pairwise interaction terms was nominally significant.

Using the IVW method, we identified two genes with nominally significant associations with BC risk (Fig. 6 A).

We detected no differentially expressed genes in acutely treated rats (although 423 genes were nominally significant).

Only sphingomyelin measured using HILIC (hydrophilic interaction liquid chromatography/positive ion mode) was nominally significant but with a small effect size.

MR results with p-values < 0.05 were considered nominally significant ( Liu et al., 2023 ; Luo et al., 2023 ).

Hb level improvements from baseline were nominally significant versus placebo at 12-wk intervals assessed up to wk 96 (Figure).

The majority of published CNV studies have focused on microduplications and microdeletions that reach a nominally significant P-value, and thus these studies only report the frequency of already-established risk-bearing CNVs.

The thalamic radiation tract subset was also consistently associated with all measures of depressive symptoms (nominally significant for the variability measure and significant for all other measures).