“nominally significant”

We also found a nominally significant burden of rare, damaging variants in ID patients with a behavioral or psychotic disorder.

No instruments for the microbial taxa where we found nominally significant differences reached the significance threshold required for BMI.

Conclusion: Atogepant demonstrated nominally significant reduction of migraine-related disability, including absenteeism and presenteeism; improved work productivity; reduced activity impairment; and greater global impression of change among people with EM and prior inadequate response to 2–4 classes of OMPMs.

However, there was a nominally significant difference in the strength of conspiracist beliefs about Kampusch between Time Point 1 ( M = 3.72, SE = 0.09) and Time Point 2 ( M = 3.45, SE = 0.10), although the effect size was small, F (1, 524) = 3.98, p = 0.046, η 2 p = 0.01.

Of 25 genes in this gene set, 22 were mapped with variants and 15 showed nominally significant associations.

From a methodological perspective on GWAS analyses, our practical approach is supported by investigations demonstrating nominally significant results occurring significantly less often than expected for low-MAF SNVs, resulting in a conservative bias [ 54 , 55 ].

Our GxAge-eQTL analysis reported a nominally significant P value of 0.014.

There were a few exceptions, such as a nominally significant causal association between BC risk (FinnGen and BCAC) and CCDC134 (UKPPP) and a causal association between BC risk (BCAC) and CDH1 (UKPPP).

However, the other nominally significant SNPs were also included in our SNP set (see below).

We provide a full list of genes that do not pass multiple testing correction, but still show nominally significant differences in gene expression ( Supplementary file 2 ).

Of these nominally significant regions at the whole-brain level ( P uncorrected < 0.001), the effects of the diagnosis on the insula, anterior cingulate cortex (ACC; Fig. 4 A, x , y , z = 1.5, 40.5, 19.5, T = 5.19), thalamus and frontal areas and the effects of cognition on the ACC ( Fig. 4 B, T = 4.35), insula, hippocampus, amygdala, superior temporal gyrus and frontal areas were still significant after applying the FWE correction ( FWE - corrected P < 0.05, Supplementary Tables 1 and 2).

Initial analyses across the entire cohort identified numerous nominally significant associations (Table 3 ).

Several nominally significant correlations were found between individual differences in the mean activation of the contrast maps in the significant ROIs and reading, VWM and phonology (see Supplementary Table S2 ).

In the vaccinated versus unvaccinated analysis, several outcomes showed nominally significant associations at the 95% confidence level that did not survive Bonferroni correction.

When we evaluated evidence for association across previously identified candidate genes, we observed a small excess of nominally significant p -values.

The analyses showed a nominally significant association between dystrophin expression and tumor grade.

We note that while the core findings of this study—including the massive increases in pregnanolone, its conjugate, 17-hydroxypregnanolone, and 5β-pregnane-3α,20α-diol—withstand stringent FDR correction (q < 0.001; Table 2 ), a subset of nominally significant changes in minor downstream metabolites (e.g., epietiocholanolone conjugate, 5β-androstane-3α,17β-diol conjugate) should be interpreted as exploratory observations pending independent replication ( Table 2 , footnote).

Despite differences in genotyping methods, filtering, FDR controls, choice of covariates, and reference assemblies, all 15 loci were at least nominally significant in both tests, and 6 of 15 were identified as eSTRs/eVNTRs in both studies.

The results were also similar when stratified by sex (Figures S13 and S14 ), with some associations becoming only nominally significant.

There was a nominally significant interaction between COPD status and the effect of finerenone on improvement in NYHA class from baseline to 12 months, such that finerenone appeared to improve NYHA class in patients with COPD, but not in those without COPD ( p interaction = 0.048) ( Table 3 ).

Vision impairment was a nominally significant predictor.

Prior to inclusion in the GRS, SNPs identified in the EA or East Asian meta-analyses were screened to have at least nominally significant associations with BP in the Han Chinese sample.

Causal estimates of genetically predicted EAA and cognitive function In the 2-sample MR analysis, nominally significant associations between genetically predicted EAA and cognitive tests are presented in Table 3 .

Despite a clear functional overlap, the individual transcriptional changes differed, with only a subset (20%–30%) exhibiting nominally significant changes with both ASOs, which could reflect off-target effects or donor-specific differences.

Quantile-quantile plots of observed versus expected P values (minor allele frequency (MAF) >0.01) for all AML cases and cytogenetically normal AML cases showed minimal inflation of test statistics across all three GWAS after adjustment for nominally significant principal components in each GWAS ( λ GC = 1.021, 1.025, and 1.055 for all AML in GWAS1, GWAS2, and GWAS3, respectively; λ GC = 1.006, 1.011, and 1.025 for cytogenetically normal in GWAS1, GWAS2, and GWAS3, respectively) (Supplementary Figs. 6 – 7 ), minimizing the possibility of hidden population stratification and cryptic relatedness.