“nominally significant”

We additionally conducted tissue specificity analysis using XWAS summary statistics for 145 phenotypes with at least one nominally significant association using MAGMA (v1.08) and GTEx v8 with 30 tissues.

These two mtSNPs also achieved nominally significant levels for association with BMI.

We considered a SNP as a candidate for pleiotropy analyses if a): exceeded significance threshold for multi-trait test at PaSPU < 1.25 × 10 –8 , a conservative threshold [ 47 ] which accounted for multiple testing on likely low frequency SNPs and the number of traits tested, and b) nominally significant for inflammation and at least one adiposity trait in univariate GWAS results.

Tests with Benjamini‐Hochberg (BH) adjusted P value less than false discovery rate (FDR) of 0.05 were identified as statistically significant and unadjusted P <0.05 as nominally significant.

Applying the method to testicular cancer, we found a nominally significant M×M interaction between single nucleotide polymorphisms from C-Kit Ligand ( KITLG ) and Sex Hormone Binding Globulin ( SHBG ) using 210 families (relative risk 2.2, P = 0.03).

The proposed linkage disequilibrium block test consists of the sum of squares of nominally significant univariate statistics.

It is of note that a recent major GWAS reported a nominally significant genetic correlation between schizophrenia and AD 19 .

We identified 1 SNP, rs6543833, approaching genome-wide significance at P = 8.07 × 10 −8 and several nominal SNPs associated with FSH levels in African American and Caucasian women, respectively, whereas, only nominally significant variants were associated with AMH levels.

Spearman correlation with p < 0.05 was considered as nominally significant.

Indeed, merely four loci showed a nominally significant effect in South Asians, suggesting that loci identified in European GWAS do not explain the high WHR ratio and the risk of central obesity in the Asian population [ 28 ].

Comparison of allelic frequencies between high myopia and control groups revealed nominally significant difference for five polymorphisms ( P asym < 0.05).

Other nominally significant taxa, such as Oscillibacter and Eubacterium (ruminantium group), have been implicated in inflammatory phenotypes or trimethylamine-related pathways associated with cardiometabolic complications [ 32 , 36 ].

Results: Atogepant treatment resulted in a nominally significant higher proportion of participants achieving the ability to think clearly compared with placebo as early as 2‐hours postdose in the first treated attack (OR: 1.78, Figure 1); this effect increased over time through 4‐ and 8‐hours postdose (OR: 3.39, 3.73, respectively; Figure 1).

An aggregate genetic risk score from the nominally significant loci accounted for 17% of the variance in discounting.

After covariate adjustment, all 359 genes retained a positive ZM-associated effect and 358 remained nominally significant in the age/sex-adjusted model, supporting the robustness of the ZM-upregulated transcriptional program (Table S1).

Finally, although false discovery rate correction was applied to support interpretation of the main OCTA findings, some nominally significant results did not remain significant after adjustment and should therefore be interpreted with caution.

In a nationally representative twin cohort study from Sweden, a symptom-based analysis aimed at exploring potential associations between ASMT and autistic-like traits in the general population identified a nominally significant link in girls between a single-nucleotide polymorphism (rs5949028) in the final intron of ASMT and impairments in social interaction.

In contrast, metabolites with an FDR greater than 0.05 but a p-value less than 0.05 were deemed to have a nominally significant causal relationship and were identified as potential risk factors.

For the group of excitability genes, however, all three samples independently showed nominally significant or suggestive evidence.

Although BMI and physical activity showed nominally significant correlations in males before correction for multiple testing, these associations were no longer significant after false discovery rate adjustment.

Group differences over time were evaluated visually; non-overlapping 95% CIs between groups were interpreted as a descriptive indicator of nominally significant divergence.

Among all loci, 59/60(98.3%) loci demonstrated consistent directionality and had a nominally significant P value below 0.05 between the two hospitals, suggesting little heterogeneity and high fidelity of our genetic discoveries (Supplementary Data 2 , Supplementary Fig. 4A , Supplementary Fig. 4C ).

Additionally, the analysis of a genetic overlap between pathological gambling and alcohol dependence revealed, by polygenic risk score analysis of the alcohol dependence dataset, a one-sided nominally significant P -value in individuals with pathological gambling.

After adjusting for multiplicity, circulating cytokines remained the only group exhibiting nominally significant indirect effects.

Similarly, when genes were tested individually for their correlation with nicotine SA, none of the nominally significant genes passed a genome wide correction for p values.