“nominally significant”

The choice of the formal significance level of p < 0.00067 has guarded against the possible effect of multiple testing leading to spurious nominally significant results.

Many causal correlations in this study were regarded as nominally significant due to failing the Bonferroni corrected test.

Among T2DM individuals, there was a higher proportion of CAD individuals having Framingham risk above 20%, as compared to CAD-free individuals, with a nominally significant difference.

However, even a nominally significant change in body weight can sometimes prove insufficient for patients expecting individually satisfying results from dietary cooperation.

An observed p- value equal to or less than 0.05 was considered nominally significant evidence for a potential causal association, yet to be confirmed.

For each suggestively associated ROI ( P permuted < 0.10) we next selected the ‘independently associated’ SNPs in a backward stepwise logistic regression until only nominally significant SNPs remained in the model.

Although we confirmed a nominally significant association with cancer risk for many of the HPV seropositivity GWAS signals, others were not associated with cancer.

Machado and colleagues, in an umbrella review of published systematic reviews and meta-analyses, observed nominally significant results to suggest an association between depression and all-cause mortality in the general population [ 34 ].

The study identified three independent signals in the region, at 96.59 Mb (rs11592737), 105.63 Mb (rs1253130), and 124.25 Mb (rs2250804), with nominally significant evidence of association.

Urgency NU-PGS and PU-PGS both exhibited nominally significant associations only with nicotine use initiation.

Nominally significant ORs were observed for TNF and SERPINE1 (PAI-1), with the latter result consistent with previous results in persons of European descent 10.

For each sequence class, for each integer period, we evaluated the fraction of sequences that returned a nominally significant BWB test probability ( P BWB (period-10) < 0.05).

However, by making some simplifying assumptions, and noting that a total of 105 interactions were tested (nine possible interaction effects were tested for the 15 possible pairs of polymorphisms minus 30 interactions since only dominant coding was used for the BDKRB2 C181T polymorphism), one can estimate that under the null hypothesis, one would expect 2.6 and 10.5 interactions to be nominally significant at α = 0.025 and α = 0.10, respectively, by chance alone (as described earlier, these are the two uncorrected significance levels used in the present study).

The changes in expression for these and several other genes observed after EED overexpression were all nominally significant (Supplementary Table S2 ).

When focusing on typical butyric acid producers like the Lachnospiraceae and Ruminococcaceae families 18 , one genus in the Ruminococcaceae family ( Anaerotruncus ) and five genera in the Lachnospiraceae family ( Lachnospiraceae UCG_003 , Eubacterium eligens group , Coprococcus , Lachnospiraceae CAG_56 and Ruminococcus gnavus group ) had nominally significant different abundance in patients and controls, but as the first four genera were more abundant in controls, and the latter two in patients, we could not show a consistent pattern (Supplemental Fig. 2 ).

We observed four nominally significant interactions between 25-hydroxyvitamin D quartile and CDA-level SES covariates on skin cancer risk ( table 3 ).

Results Genetic correlation between skin and GIT diseases Among the 28 pairs of skin and GIT diseases, 22 pairs were nominally significant in at least one global genetic correlation method, and 19 pairs were significant in both.

Tau pathology on biopsy is the primary histologic measurement that correlates with selected proteins, with three proteins showing nominally significant trends, and GFAP shows a nominal inverse relationship with VGF (Figure 2B ).

Reported in Table 5 , moderation effect estimates for age, non-verbal IQ, insistence on sameness and sensory motor behaviours were all small and none even nominally significant.

(2014) identified nominally significant cognitive associations for four SNPs that have previously been robustly associated with SCZ susceptibility and discovered polygenic risk scores for SCZ were associated with lower general cognitive ability.

Given the 4 MR estimations, statistical significance was defined as a p value <0.0125 (0.05/4) after the Bonferroni correction; a p value between 0.05 and 0.0125 was regarded as nominally significant.

After adjustment for baseline characteristics, there was a nominally significant 12% reduction in risk.

Interestingly, an earlier study that performed RNA-seq within isolated platelets has observed decreased expression of PF4 and PPBP with age ( n = 154 [ 25 ]), while studies in whole blood show upregulation with age (current study: both genes significant; in the previous study [ 3 ]: PF4 not tested, PPBP nominally significant).

After performing multivariable logistic regression and retaining nominally significant variables, two and three vaccination shots remained significant, and their OR were 0.445 and 0.558 in the optimal model (Two shots: p = 0.004; Three shots: p = 0.017) ( Figure 1 ).

Nominally significant genetic correlations between Hannum-EAA and lifestyle factors including smoking behaviours and education support the hypothesis that Hannum-based epigenetic ageing is sensitive to variations in environment, whereas Horvath-EAA is a more stable cellular ageing process.