“nominally significant”

For this, we used LeafCutterMD 14 to identify junctions that exhibited a nominally significant p value for outlying expression and removed events represented within external reference datasets of annotated splice junctions (STAR Methods).

Finally, in the comparison between the non-oncocytic tumor variants and the general cancer variants, there was a nominally significant difference only in the Complex V genes (though this was not significant after correction for multiple testing).

Such factors may obfuscate the interpretation of nominally significant causal results, and lead to null findings.

Although nominally significant associations were observed for five SNPs with SD, only the association of the nonsynonymous variant G80T with OD remained significant after correction for multiple testing.

From a statistical point of view, our analyses were not adjusted for multiple comparisons, thus some of the nominally significant RRs might be false positives, although a rationale existed for our findings.

The respective GxE interaction was nominally significant in the full cohort, explaining 0.08% of the variance in depression.

2012 ) to test for an association between GRR haplotype and virus survival phenotypes, we detect a small but nominally significant association of GRR haplotype with longevity of DCV-infected flies.

In summary, our study suggests that there is an excess of loci showing nominally significant heterogeneity (p Het <0.05) between effect sizes in adults and adolescents for HDL-C.

Interestingly, MDD PGS, the primary indication for sertraline, showed a nominally significant positive association with its median dose, with an even more significant effect on maximum dose (Supplementary Table 6–7).

For evaluating the Sequenom MassARRAY assay data of the 29 SNPs of RANK, RANKL and OPG, p values < 0.05 were defined as nominally significant, bonferroni correction for multiple testing was applied for the total number of SNPs in this study when assessing relationship between Minor Allele Frequency and individual SNPs (the corrected level of significance was p = 0.05/29 = 0.0017).

Reverse MR analyses revealed no widespread and robust reverse causal associations; only 2 nominally significant signals were detected, which had poor analytical robustness or negligible clinical relevance and did not affect the core forward causal inferences.

We focus on mutually independent triplets, whereby the eSNP association with either of the two transcript remains nominally significant given the respective other transcript, as well as and directionally independent triplets, where only one of these association signals remains nominally significant given the level of the other transcript.

Model assumptions for collinearity were checked (Hosmer–Lemeshow test in logistic regressions, and Durbin–Watson in linear regressions) and a P -value of <0.05 was considered nominally significant.

A nominally significant positive correlation was also observed between HCV‐negative HCC and immune cells, including the neutrophil, monocyte, and lymphocyte count.

In monozygotic twin studies, hypomethylation of all MAOA CpG sites has been negatively associated with depressive symptoms, but not with childhood trauma; whereas, hypermethylation of the MAOB gene shows a nominally significant association with childhood sexual abuse ( 134 ).

Of these, a nominally significant association was observed for rs1561198 ( VAMP5 / VAMP8 ) with IL-6 and calprotectin; rs17609940 ( ANKS1A ) with C3; rs2075650 ( TOMM40 , APOE ) with hs-CRP and IL-6; rs264 ( LPL ) with C3; and finally rs599839 ( SORT1 ) with fibrinogen.

Among the 29 lipids that showed nominally significant associations, only four showed an inverse association.

A nominally significant Acute Physiology and Chronic Health Evaluation IV (APACHE IV) × LAR interaction (hospital mortality, P for interaction=.02) indicated stronger LAR prognostic effects in lower-severity patients (APACHE IV≤70), representing within-biomarker effect modification requiring prospective validation.

Two nominally significant negative correlations were observed, both for NRG3 (not different from the 1.1 negative correlation expected by chance in 44 tests, underlined in Table 1 ).

In addition to the consumption of red meat and fish, several other nutritional phenotypes were nominally significant, therefore, we used the principal component analysis (PCA) based on food consumption-related phenotypes (fish, red meat, salt, sugar, vegetable intake, and leptin) to investigate differences in food pattern between DLSS and controls (Fig. 2 A).

for both association pairs remain nominally significant given the respective other transcript versus ‘uni-directional’ triplets where association is directionally independent ( Figure 1 a).

That said, a pair of adjacent bins in bipolar disorder (10.2 and 10.3) and 2 pairs of adjacent bins in schizophrenia (3.4 and 3.5, 6.5 and 6.6) were implicated by nominally significant GSMA findings.

We then used PanPhlAn3 47 to analyze the gene repertoire of the seven species that were detected in at least 10 tCeD cases and 10 controls and showed at least a nominally significant association between analysis group and interindividual strain distance or strain cluster distribution (see partition around medoids (PAM) clustering below).

Approximately 15% (13% to 17%) of genes in each pathway had nominally significant gene-level associations with resilience ( Table 2 ).

These average gĉp estimates represent only Bonferroni significant relationships; however, each trait pair listed was nominally significant after conditioning with all other EDU and SES phenotypes but not significant in the unconditioned experiment ( Table 1 ).