“nominally significant”

It is worth noting that three genetic variants in the area of GREB1 (close to rs13394619) and CDKN2B-AS1 (close to rs1537377) also showed nominally significant associations with endometriosis [ 186 ].

In comparison, male sex-score genes were only enriched for the downregulated frontal-cortex gene set, with nominally significant effects among other brain tissues.

A p -value of < 0.05 was considered nominally significant.

These reproducible signals, genome-wide significant in phase two and nominally significant in phase one, are located in the FADS1-FADS2 gene cluster, hereafter referred to as the FADS locus.

Pathway enrichment analysis revealed nominally significant enrichment in pathways related to muscle function, particularly ion transport, muscle contraction, and structural integrity; however, these results did not remain significant after Bonferroni correction ( Supplementary Table 8 ).

Gene set enrichment Gene-marker correspondences were established based on whether independently associated variants reside within genes, or whether nominally significant variants influence tissue-specific gene expression.

As no proteins met the stringent significance threshold (adjusted p-value < 0.05 and absolute fold change > 1.5), results were reported based on nominal criteria: proteins with an absolute fold change > 1.5 and nominal p-value < 0.05 were considered nominally significant.

rs1996147 demonstrated Δ MAFs of 8.6% in EUs and 5.9% in AAs in our NGS discovery analysis, and showed nominally significant association with bipolar disorder in a study of circadian rhythm genes [ 42 ].

Rs715 also yielded nominally significant female-specific associations with plasma TMAO and other urea cycle metabolites but not with intermediates, such as homocysteine, methionine, dimethylglycine and sarcosine ( Table 4 ).

De Jong and colleagues 29 also used a dense pedigree ( N = 300) with BIP and MDD cases and showed nominally significant BIP and SCZ PRS in affected members compared to unaffected members and population controls.

The four non-replicated proteins were all nominally significant in the replication data, with p -values ranging from 1.5 × 10 −2 to 2.9 × 10 −3 , with the same direction of change in cases compared to controls (the mean differences ranged from 0.90 to 2.0).

After implementing the Bonferroni correction, a P -value of below .008 (calculated as 0.05/6) was considered to be statistically significant, meanwhile P < .05 was regarded as nominally significant. 3.

Given the large number of lipidomic and amino acid traits analyzed (252 in total with TSMR and drug target MR), we considered p < 0.01 as nominally significant, and significant association was determined based on a Bonferroni-adjusted p-value threshold of 0.00019 (calculated as 0.05/252).

Two nominally significant associations in the expected direction were observed in the Italian sample, but did not withstand correction for multiple testing and were not validated in the Israeli sample.

There were no other nominally significant associations between BD or SCZ PGRS and any of the other CVD biomarkers.

Primary tests of associations with global measures of white matter integrity The results in the top panels of Table 1 show that no CADS dimension was significantly associated after FDR correction with global FA averaged across the 15 tracts, whether TICV was controlled or not, although there were nominally significant associations of both parent- and youth-rated prosociality with global FA.

PTSD showed a Bonferroni-significant association with increased CLBP+SDD (β = 0.180; 95% CI, 0.100 to 0.261) and nominally significant associations with increased CLBP-only (β = 0.099; 95% CI, 0.030 to 0.169) and reduced SDD-only (β = −0.303; 95% CI, −0.504 to −0.102).

Finally, in reported results of association with blood pressure from the Framingham Heart Study, rs4427330 has been nominally significant, though not reported since did not meet genome-wide significance [ 41 ].

Finally, our MR study showed that causal association between left-HGS and the development of LID was nominally significant, while genetically predicted right-HGS was significantly associated with LID after multiple testing correction.

However, the maternally inherited G allele was significantly associated with lower ApoB/ApoA1 ratio: the differences in the effect of the paternal and maternal G on ApoA1 and APoB/ApoA1 ratio were nominally significant, whereas the POE on ApoA2 was significant after correction for multiple testing.

We did not find any evidence of a nominally significant association between frailty and the other SNPs.

Finally, the most consistent risk factor for time to insulin was isoleucine level, which was nominally significant in the discovery cohort (HR = 1.09, 95% CI = 0.96–1.25), a risk factor for incident diabetes in MDC (HR = 1.48, 95% CI = 1.26–1.74) and DESIR (OR = 23.88, 95% CI = 3.13–182.31) as well as prevalent diabetes (OR = 10.94, 95% CI = 3.94,30.32).

A two-sided raw p -value < 0.05 was considered nominally significant.

Nominally significant associations of main effects on methylation of a single CpG site were observed at intron 3, intron 7, and the 3′-end of the gene.

For secondary outcomes, the combination of note was associated with a nominally significant improvement in hyperactivity/impulsivity scores on the investigator-rated Conners Adult ADHD Rating Scale.