“nominally significant”

Setting a relaxed significance threshold ( P value < 0.05), we compared the fold change of DE for the APP effect ( y axis) and BD10‐2 effect ( x axis) to gauge the correlation of genes nominally significant in both (379 genes; Figure 7B ).

In this case, we will report for each primary endpoint a nominally significant level and the corrected p -value determined by the method for multiplicity adjustment.

Considering rs174594, nominally significant associations with these three genes were found in 29, 28 and 4 tissues, respectively.

Inspection shows, however, only two paths from disengagement to COPE items were nominally significant (standardized β = 0.87 and 0.97, respectively; p s < 0.05).

P -value ≤ 0.05 was considered as nominally significant for all analyses.

These associations were nominally significant and should be interpreted cautiously in the context of multiple testing.

For four previously tested restriction fragment length polymorphisms, only one (referred to as ApaI ), tagged by the SNP rs79628898, had a nominally significant p-value in AAs; none of these polymorphisms were associated with CRC in Caucasians.

MR analysis results According to the gut microbiota and TBC RESP (RTB1) data, the IVW method revealed that 7 microbial taxa have a nominally significant association with RTB.

Continuous score analysis demonstrated a nominally significant incremental association with overall survival, but this was a post hoc exploratory finding that requires prospective validation before any prognostic application.

Although several secondary COP variables demonstrated nominally significant group × time interaction effects before adjustment, none of these variables retained statistical significance after correction.

Statistical tests resulting in P <0.010 can therefore be considered formally significant and those that achieved P <0.050 as nominally significant.

However, plasma levels of NAbs-Aβ19–30 (only at a nominally significant level) and NAbs-Aβ25–36 were negatively associated with the centiloid score ( Fig. 3, C and D ).

For traits in which the exposure–outcome associations were nominally significant in all four estimators and reached test-wide significance ( P < 0.05/9) in two out of four (Supplementary Table 20 ), we applied the outlier-robust and pleiotropy-robust estimators MR-RAPS 94 and MR-PRESSO 95 .

Despite high screen failure and small sample size, a nominally significant increase in sHCO 3 – was seen for sodium zirconium cyclosilicate versus placebo.

Initial differential gene set enrichment analysis (GSEA) returned a broad list of nominally significant pathways ( Figure S4 ).

p values of <0.05 were considered nominally significant (shown in Figure 1 , Figure 2 , Figure 3 and Figure 4 ).

We chose the nominally significant microbial taxa from the MR results and compared a basic linear model (microbial abundance and fasting serum triglyceride concentration) with a linear model including ethnicity, and compared the two models with an ANOVA.

However, the nominally significant correlation between the ΔMI map and the U-T axis map was not robust to significance testing using the spin-test method to control for spatial autocorrelation in the maps, and the correlation between the ΔMI map and the U-T axis map was evidently not as strong as the correlation between the MI map and the U-T axis map.

Although this GWAMA also included participants from other ethnic groups, the direction of association for the same reference alleles were largely similar between the South Asian and multi-ethnic samples (concordance of 70% and 92% for all variants, and nominally significant SNPs respectively, data not shown) 9 , which substantiates the use of this dataset.

When analyzing the three major groups (controls, benign and malign) separately we found 3 of the proteins to have nominally significant influence by age in the benign and control groups out of which one remained significant after adjustment for multiple hypotheses testing.

Adjusted for imbalances in baseline characteristics or nonadherence, a nominally significant reduction in the primary composite end point was found. 41 Additionally, further prespecified secondary analyses of EVOLVE demonstrated a significant risk reduction for parathyroidectomy 40 or the development of calciphylaxis 42 with the use of cinacalcet.

A nominally significant effect towards an increased -1562 T allele frequency in MS patients group was found.

Despite the fact that both variants were nominally significant in the meta-analysis of the replication data, the PRNP variant was the only genome wide significantly associated to sCJD in the pooled meta-analysis.

Exome-wide burden of recessive genotypes In autosomes, there was no significant excess of recessive genotypes in probands after correcting for multiple testing (homozygous, compound heterozygous and all recessive genotypes, two variant types and two MAF thresholds), although there was a nominally significant excess in probands of rare (MAF ⩽1%) nonsynonymous compound heterozygosity ( Table 1 ).

Additionally, not all nominally significant findings were supported by adequate statistical power.