“nominally significant”

We found a nominally significant association between a 5-alpha-reductase type 2-gene-linked polymorphism (rs2208532) and ELT, but this association did not remain significant after correction for multiple testing.

Of these, 8 were nominally significant in exactly one domain, 11 in two domains, and 7 (including APOE4, APOE2, ABCA7, USP6NL, WNT3, CD2AP , and EPDR1 ) in all three domains.

In addition, we also included those SNPs that were in strong LD ( r 2 > 0.9) with nominally significant SNPs in the validation stage.

To understand the biological features, we performed a GO enrichment analysis using the DE results from 22,189 identified genes of the young and mature tuft cells and plotted the enriched genesets as depicted in Figure 6 C, with all nominally significant GO terms (not adjusting for multiple testing) listed in Table S3 .

However, the lower abundance of Eubacterium was only nominally significant (β = −0.33, P -trend = 0.002).

Result Nominally significant associations were observed between CpG sites within several of the EWAS that were performed; however, no individual CpG sites remained significant after FDR correction.

To control for the proportion of false positives in multiple testing, we separately performed a false discovery rate (FDR) correction for nominally significant associations between dietary factors and each selected disease.

For instance, miR-143-3p showed a nominally significant positive correlation with hippurate, a gut microbiota-derived polyphenol metabolite previously associated with asthma [ 5 ], in individuals from metabo-endotype 2, while a negative correlation was observed in those from metabo-endotype 3.

This association was nominally significant and represented a small effect size.

The criteria for prioritization were a nominally significant association p-value (< 0.01) in the sequencing data or because the variant was not present in three catalogs of human variation (dbSNP build 137, ESP 6500 release, and 1000 Genomes April 2012 release).

All three meta-analysis two-sided tests (fixed effects, random effects, and weighted Z -score) were all nominally significant in both BD and SCZ groups (Table 1B ).

While this association was nominally significant in the multiple imputation analysis, the effect size was smaller among females and did not meet the threshold after adjusting for multiple comparisons [β = 0.23, 95% CI (0.01–0.14), q = 0.34].

Nominally significant associations were found between goiter, aortic aneurysm, myeloma, and amyotrophic lateral sclerosis and the rs2653349 SNP.

Future research combining data across cohorts should test our nominally significant findings to further elucidate the pathogenic relevance of variants considered PD-risk or severe GBA1 variants in men and women with Parkinson’s disease, increase statistical power, and provide more definitive conclusions.

There were 223 IR-associated genes in SAT containing a total of 336 nominally significant differentially methylated sites (DMS).

Twelve pathways show a nominally significant result: Focal junction assembly, cleavage of lamina in apoptosis, systemic lupus erythematosus, glycan catabolism, TGFi, OA transport, fatty acid biosynthesis, NF-1, Myc Mad Max, type 1 diabetes mellitus, and triacylglycerols degradation.

Repeated-measures analysis of covariance (ANCOVA) revealed nominally significant time-by-group interactions in the left posterior orbital gyrus (POrG), left posterior insula (PIns), left subcallosal area (SCA), and left transverse temporal gyrus (TTG), with only the left POrG remaining significant after false discovery rate (FDR) correction.

Finally, the tendency toward associations being nominally significant, but not significant after multiple testing corrections, may be a result of the smaller sample size.

Indeed, according to MNEA, 114 out of 123 individual AGSs had nominally significant enrichment score (z-score >1.96).

Maternal age also showed a nominally significant effect on SPQ-B scores, but not on NEO-FFI scores.

Thus, the nominally significant bivariate correlations should be interpreted cautiously as preliminary descriptive evidence rather than confirmatory findings.

Nominally significant associations with BMI were observed for 28 SNPs.

3 b), whereas their “complementary” associations (CKD-EEAA and eGFR-PhenoAA) were nominally significant (Additional file 2 : Fig.

An FDR < 0.05 is considered nominally significant.

In addition, we identified a total of 93 FDR significant DMRs, of which 14 were nominally significant in the ALSPAC study.