We found that rs3778609 remained nominally significant in a joint model adjusting for rs140068132 (Table 2 ), although the adjusted odds ratios were attenuated.
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p=0.08
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A p value lower than 0.05 was considered nominally significant.
The effect of allocation to rt-PA on stroke outcome in patients ≤80 and >80 years of age will also be estimated (again, adjusted for other baseline covariates and treatment modifying effects of those covariates) and, if evidence of independent effect modification by age is observed, a test for difference in the two log-odds ratios will be performed (by comparing the difference in log odds ratios divided by its standard error against a standard normal distribution, a test that will be deemed nominally significant if the two-sided P -value is less than 0·05).
P < .0083 (0.05/(exposure * outcome), Bonferroni multiple comparisons) is considered a statistically significant result, and P < .05 indicates a nominally significant result.
When the Bonferroni-corrected p-value threshold was less than 0.017 (correcting for 3 exposures and 1 outcome), the correlation was considered to have statistical significance, while a p-value less than 0.05 was regarded as nominally significant evidence of a potential causal association ( 46 ). 3 Results 3.1 Assessment of immune infiltration in OA patients Given the importance of changes in the immune microenvironment contributing to the progression of OA, we compared the immune scores of OA and normal individuals in the discovery dataset, which provided a qualitative assessment of the immune microenvironment ( Figure 2A ).
Of these genes, 24% showed differences at a significance level of p < 0.01 (paired t -test, with ~12 nominally significant genes being expected by chance, FDR = 4%).
Other nominally significant genetically correlated pairs (not significant after Bonferroni correction) include correlations between endophenotypes and cardiovascular disease, diabetes, lung function and blood pressure ( S10 Table ).
Also, p -values <0.05 were considered nominally significant. 2.5 Sensitivity analysis Given that the IVW method could be biased by pleiotropic IVs, sensitivity analyses were employed to address the pleiotropic effects in the causal estimates.
nana is only nominally significant, and the authors are unaware of any variation in lifestyle habits or gender-specific environmental conditions which would explain the observed higher rates of H. nana -associated infection in females.
The P value < 0.05 as threshold for nominally significant differential expression.
Nominally significant associations included a positive correlation between Alzheimer's GPS and Conner's Impulsivity; and positive associations between Autism Spectrum Disorder GPS and Autism Quotient: Attention Switching.
Some associations were nominally significant.
This was nominally significant in the multiple imputation data set but not in the per protocol analysis This was not found in the per protocol analysis Other secondary and tertiary outcomes were not affected.
For four out of five super-populations, the SNP DAF test reported nominally significant support for positive selection at human-inserted promoters.
To avoid ambiguity arising from nominally significant associations, we emphasize that only HS, osteoarthritis, BMI, overweight, excessive hairiness, T1D, T2D, and eosinophil count remained statistically significant after FDR correction.
None (lead replication SNP: rs860447, MAF = 0.26, p = 0.60, Yale-Penn/STARRS EA-EA meta p = 6.4 × 10 −3 ) replicated in the STARRS EA data, but 34 of the top 98 EA SNPs were nominally significant in the STARRS LAT samples, and, remarkably, all 98 had effect direction consistent with what we observed in Yale-Penn EAs; the lead SNP from Yale-Penn EAs was nominally significant in STARRS LATs (rs1677091, MAF = 0.28 p = 6.52 × 10 −3 ) and improved in a meta-analysis of the Yale-Penn EA and STARRS LAT samples (meta p = 4.7 × 10 −9 ).
Results were consistent for primary and secondary outcomes and there was no suggestion of benefit in any of the prespecified subgroups except for a nominally significant interaction for diabetes which is almost certainly the play of chance.
Four mates of biopsy-proven sarcoidosis patients also have sarcoidosis, yielding a nominally significant increased risk of being diagnosed with the disease.
All statistical tests were two‐sided, and p < 0.05 was considered nominally significant.
IVW estimates were nominally significant for two metabolites, annotated as 3-(4-hydroxyphenyl)lactate and alpha-hydroxy isovalerate.
Pedigrees linked to a region of interest were defined as having nominally significant linkage evidence if their LOD score was greater than 0.588, which corresponds to a p -value of 0.05, not accounting for multiple testing.
Previous GWAS have found nominally significant associations between the C-allele and addiction-related outcomes, including the number of unsuccessful stop-smoking attempts and the frequency of feeling guilt or remorse after drinking alcohol in the last year 96 .
An empirical p < 0.05 within each database was considered nominally significant. 2.10.
The other three SNPs were at least nominally significant in the analysis of number of teeth erupted at age 15 months ( P between 0.028 and 3.5×10 −6 ), in all instances the same alleles associated with fewer teeth erupted in the respective dentition.
TNFSF15 was found to be only nominally significant in the GWAS study, contrasting with prior reports as mentioned previously.