“nominally significant”

In CUPID B, the change in UAS7 was statistically significant (EU hierarchy)/nominally significant (non-EU hierarchy); ISS7 at week 24 did not meet significance; and Weekly Hive Severity Score (HSS7) at week 24 was nominally significant.

The overall omnibus p-value for surgical approach was p = 0.125 (non-significant); nominally significant individual contrasts for specific approach categories reflect sparse-data instability in the reference group and should not be interpreted as independent effects.

S5a), although power was sufficient to identify nominally significant associations (Additional file 1: Fig.

The longer list of candidate biomarkers includes the top biomarkers from discovery step ( ≥ 90% of scores, n = 28), the top biomarkers from the prioritization step (CFG score ≥ 8, n = 32), and the nominally significant biomarkers after the validation step ( n = 5), for a total of n = 65 probesets ( n = 60 genes).

Nominally significant findings ( P uncorrected < 0.05) with 0.05 ≤ P FDR < 0.1 were also reported as exploratory. 2.4.2 Correlation with rumination traits We explored associations between metrics showing significant differences in the rumination-distraction comparison and rumination traits.

Nevertheless, we did observe more nominally significant and statistically significant differences in the relative abundance of bacterial taxa in the postweaning piglets and sows, respectively, between two types of farms.

Although there was a trend for all the qRT-PCR data to confirm the array data, only THRAP3 and TFAM were nominally significant (paired T -test).

Subsequently, an enrichment analysis was performed among these variants to determine whether an excess of nominally significant values was observed.

For protein-coding genes, a 53% (1.64 SD) elevation in the mutation rate will thus never be nominally significant. 3.2 Length scale of regions with biased mutation rates The neutral background mutation rate is predicted by the statistical mutation-rate model relying on a number of genomic features known to correlate with the mutation rate in cancer ( Bertl et al. , 2018 ).

LD lookup variants were chosen using the following criteria: (1) they were less than 1,500 kb away from the lead variant; (2) they had a P < 0.01; (3) and their LD squared Pearson’s correlation with the lead variant was higher than a dynamic LD threshold based on the P value of the lead variant so that the expected P value of the linked variant would be nominally significant ( r 2 = 5/inverse chi-squared survival function ( P value)).

Although some GWASs have shown nominally significant support, genes encoding GABA A receptor subunits generally have not been among the top genes identified by GWASs.

The other haplotypes did not show FDR-significant associations, although a nominally significant association was found for H8 with hypercholesterolemia (OR = 0.82, 95% CI = 0.71–0.96).

Phrases throughout the Results and Discussion like "marginally significant" and "nominally significant" should be de-emphasized or removed.

This leaves 61 traits that show a nominally significant genetic correlation with one of the cognitive traits used by Lam et al.

37.9%, p = 7.43×10 −4 , respectively), although most of the nominally significant p values did not survive the Bonferroni correction ( Table 4 ).

All eight variants were nominally significant in both populations and accounting for multiple testing ( P -value > 0.05/8 = 6.25 × 10 −3 ), there is no significant heterogeneity in the effect estimates from the two datasets (Table 1 ).

In conclusion, this subgroup analysis showed that, in adolescent patients with moderate-to-severe AD, irrespective of prior SIS use, dupilumab treatment compared with placebo resulted in higher and nominally significant treatment effects across multiple efficacy endpoints.

For migraine and T2D in contrast there was evidence of residual pleiotropic effects (significant MR-Egger intercept, Supplementary Data 17 ) after removal of potentially pleiotropic outlier variants, and the association became only nominally significant for migraine.

The exclusion of missense variants with potential aptamer binding effects is evidenced in our study, where SNPs in 96% of nominally significant protein probes associated with COVID-19 also had effects on corresponding gene expression in different tissues across gene expression datasets as curated by our portal ( Open Targets Genetics, 2019 ).

Results Hair follicle eQTLs We identified almost 3 million nominally significant eQTL signals in HFs from the occipital scalp (Fig. 1 a).

Associations with a nominal p -value < 0.05 but FDR ≥ 0.05 were reported as suggestive or nominally significant evidence.

The results were followed-up in a British sample of 2025 bipolar disorder cases and 1358 controls, as well as by enrichment analysis of large GWAS data sets and by the analysis of significant physical connectivity among proteins encoded for by genes nominally significant in this study.

While these correlations were nominally significant at the p -value level, they did not remain significant after false discovery rate correction (Supplementary Table 1 ).

Grading of the Evidence Meta-analyses showing nominally significant associations were categorized into 4 evidence groups: strong, highly suggestive, suggestive, and weak [ 6 ].

Under this condition, the risk of type I error is real, forbidding us from over-interpreting nominally significant results.