“nominally significant”

However, six out of these nine SNPs were nominally significant in the current UK Biobank sex-stratified COVID-19 GWASs, including these three SNPs (rs17763742, rs115679256, and rs35477280) located in the 3p21.31 region.

As nine SNPs were investigated, Bonferroni correction was used to account for multiple comparisons: p -values below 0.006 were considered statistically significant, while p -values between 0.006 and 0.050 were considered nominally significant.

Among the tested traits, CD27 + switched memory B cells, CD27 + memory B cells, and CD27 + IgD − CD38^dim B cells showed nominally significant associations.

Nominally significant reductions were found in odds ratio in 82% to 84% of surgical procedures in both hospital and surgeon volume-mortality associations.

In this study, we primarily focused our downstream analyses on associations with P< 0.003, which include both globally and nominally significant signals.

Further mediation analyses revealed nominally significant mediation of the associations between the DMRs chr11.7597983.7598302 and chr1.39620300.39620625 with RHCV through the gene expression of PPF1BP2 (25.7% mediation) and MACF1 (16.9% mediation) (bootstrap-based tests, p-values < 0.05, but FDR >0.05, Table S16 ).

Although, in each of the three brain structures, more than 300 genes showed nominally significant left-right differences in their expression patterns, none survived correction for multiple testing.

None of the reported nominally significant associations would survive appropriate correction for multiple comparisons, so these data should be interpreted cautiously.

Although the interaction p-value for OS in RESPECT was nominally significant, these analyses were exploratory, based on small subgroups, and should be interpreted with caution.

Even so, we also discuss additional nominally significant loci due the pleiotropic nature of the Sox10 Dom mutation as shown by Owens et al.

Of these loci, 9 of the lead variants were either nominally significant or in LD with nominally significant variants in the TOPMed dataset.

After FDR correction of Tukey-derived P values, most results remained statistically significant, whereas several nominally significant outcomes lost statistical significance.

The excess significance bias is calculated according to the number of expected studies and the observed number of studies with nominally significant results.

All the nominally significant phosphatidylcholines in the brain show a positive association with cognitive global random slope indicating worsening with a decrease in the lipid level.

Other nominally significant GO terms were intermediate filament, embryonic skeletal system morphogenesis and chondrocyte differentiation ( Table 7 ) When combining the genes from iHS and ROH signatures (461 unique IDs recognised out of 523 genes), the analysis for annotation clusters yielded four clusters with at least one individual GO term enriched at p< 0.05.

Interpreting the resulting chi-square and p-value require careful consideration, as a non-significant p-value does not prove that the assumption is fulfilled while at the same time even small deviations from this assumption (which may not relevantly affect the model) may lead to nominally significant p-values due to the large sample size.

The strongest nominally significant correlations for both active treatments were with changes in the Risk Avoidance domain (LDX, r = −.44; OROS-MPH, r = −.42) and the Achievement domain (LDX, r = −.36; OROS-MPH r = −.48).

None of the variants showed a nominally significant association, which, given the smaller sample size, was not surprising.

Although these results are based on nominally significant P values, they give a possible indication that methylation of some identified sites may also have a biological role in tissues of importance for obesity and type 2 diabetes.

Oestrogen plus progestin reduced the observed hip and clinical vertebral fracture rates by one third compared with a placebo, both nominally significant.

A two-sided P value of <0.05 was considered nominally significant.

At week 12 and W24 there were nominally significant reductions in total ceramides, consistent with a reduction in inflammation, likely due to the weight loss or reduction in insulin resistance accompanying ML treatment.

17 This suggests that abnormalities in long-chain acylcarnitines reflect a common signature associated with myocardial mitochondrial dysfunction. The other nominally significant results included results for factor 2, comprised of long-chain dicarboxylacylcarnitines, unique in being the only factor which was only different in CpcPH compared to controls.

Another study implicated, for migraine in general, macromolecular complex, nucleus and protein complex-related genes [ 5 ], while a non-systematic analysis suggested enrichment of nominally significant genes in mitochondrial processes and inflammatory response between migraine patients and controls [ 7 ].

Rare variant burden testing failed to identify an association with any gene; however, it did show a nominally significant link with ERN1 and TRPC3.