“nominally significant”

All analyses were conducted using R version 4.3 (R Foundation), and a P value of <.05 was considered nominally significant.

When comparing gene-level SV associations common between mRNA and protein, we utilized relaxed statistical criteria to lower false negatives, consistent with previous studies 46 , 70 , e.g., so as not to exclude significant mRNA associations where the association was at least nominally significant for protein.

For 3671 genes, at least one predictor was nominally significant.

Among the 116 CpGs that showed significant association with BMI in meta-analysis, the path coefficients from baseline BMI to follow-up DNA methylation were nominally significant at 92 CpGs (79% of 116; P FDR < 0.05).

Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing.

To check that our results were not simply driven by the phenotypic association between AAB and alcohol dependence, we examined whether the genome-wide significant gene to emerge from our analysis of AAB remained at least nominally significant after statistically controlling for DSM-IV alcohol dependence case–control status using a gene-based test.

Here we found that correlations were positive for all conditions and were nominally significant (i.e.

Although these SNPs were not identified at genome-wide significance in our main analysis, we did confirm nominally significant interactions for these SNPs.

ROIs showing nominally significant relationships in both models were then subject to mediation analyses, as in model 6.

22 Although the diplopia responder rate was not significantly different between the groups, diplopia was completely resolved in 50% of patients in the teprotumumab group, versus 20% in the placebo group (nominally significant difference).

The Wilcoxon Rank Sum test run on the SRS-2 65 item-level questions showed a nominally significant change from intake to conclusion for five items among the 65 (Table 4 ).

We observed no consistent evidence supporting a causal association, though a nominally significant negative association was detected between HOMA-IR and dental caries 2.

A genetic analysis identified a SNP in the miR-198 gene that has a nominally significant allelic association with schizophrenia [39] .

There was a nominally significant higher frequency of mutations in cases compared with controls for POLK , PALB2 and SLX4 and a lower frequency of mutations in cases compared with controls for FBXO10 ( table 1 ).

Results Compared to the general population, nominally significant associations were noted for higher genetically predicted vitamin B-6 (Odds ratio per standard deviation [ OR SD ]: 1.06; 95% confidence interval [CI]: 1.00, 1.13; p -value = 0.036) and lower magnesium concentrations ( OR SD : 0.33; 95%CI: 0.11, 0.96; P = 0.042) with COVID-19 infection risk.

Findings with FDR values less than 0.05 were viewed as significant, while those greater than 0.05 but with P -values less than 0.05 were considered nominally significant.

None of these variants were genome-wide significant in our data, but 8/11 showed nominally significant association p values, with the allele decreasing serum B12 levels consistently also increasing the risk of pernicious anemia (Supplementary Data 5 ).

Accordingly, nominally significant findings should be considered exploratory and require confirmation in adequately powered trials.

(2016) [ 20 ] was investigated for all nominally significant differentially methylated CpG sites.

However, most of these associations were only nominally significant.

None of the CpGs remained statistically significant after multiple testing correction; however, nominally significant CpGs are presented for reference.

16 Additionally, a meta-analytical combination of eight independent neuroticism (EPQ) genome -wide linkage studies in 14 811 individuals found nominally significant risk loci on chromosomes 9, 11, 12, and 14. 17 Association studies Principally, two main approaches have been applied to elucidate patterns of genetic association in GAD or cross-disorder phenotypes related to anxiety.

Finally, for stage 2B, we advanced five loci that were nominally significant in stage2A to a second independent set of 2419 cases and 2384 controls (see online supplementary table S3).

Segregation analysis in informative families was performed, when possible, by variant-site targeted PCR and Sanger sequencing, only for variants identified in genes with the nominally significant p -values from GCA. 3.

A nominally significant positive association was observed within the small “other race” subgroup (OR: 2.16, 95% CI: 1.26–3.71); however, the nonsignificant interaction test ( p = 0.10) suggests that this is a spurious finding, resulting from a limited sample size rather than a true biological interaction.