“nominally significant”

Results Nominally significant improvements from baseline in cognitive endpoints were observed in all 3 groups; however, improvements in PF-06412562–treated patients were less than in placebo-treated participants.

The association analysis excluding these cohorts shows the ε2 SNV (rs7412, P = 1.23 × 10 –12 , β = 0.70, MAF = 0.06) remained genome-wide significant and ε4 SNV (rs429358, P = 0.02, β = -0.16, MAF = 0.14) was nominally significant (Table S4, Table S5).

Cluster 4 (17% of participants with autism), was also most strongly associated with inattention and hyper-impulsivity but also showed nominally significant associations with SRS and ADI-R-RRB, although these did not survive multiple comparison correction.

Nominally significant differences in disease risk were identified only for migraine in the case of the 5-cluster model with CT3 showing the lowest risk for migraine.

A P value level less than 0.05 was considered nominally significant.

Analyses revealed 29 nominally significant associations, from which, nine survived an FDRbl correction.

While no association was observed between ALDH1A1*2 and alcohol dependence, there was a nominally significant difference in ALDH1A1*3 allelic frequency between alcoholics (6 per cent) and controls (0), and the ALDH1A1*3 polymorphism resulted in reduced ALDH1A1 expression.

After Bonferroni correction, only glycocholate and CMPF passed this criterion; all other metabolites were nominally significant.

In addition, three biological pathways (dopaminergic synapse, cAMP signaling pathway, mineral absorption) were nominally significant.

Results EWAS-identified nominally significant DMPs enriched for lung function GWAS loci.

We found that many of the identified loci (significant or nominally significant) were completely shared (that is, ‘the 95% confidence interval for the explained variance included 1’ 42 ) by T2D and GI disorders (Table 3 ), further supporting evidence of their shared genetic basis.

Given the exploratory nature of this analysis, correlations with p < 0.05 were considered nominally significant without correction for multiple comparisons ( Pinti et al., 2020 ). 2.6 Statistical analysis Paired-sample t-tests were conducted to compare activation and connectivity features between target and nontarget conditions ( Pinti et al., 2020 ; Field, 2024 ).

None showed nominally significant interactions at the 5% level.

Corroborating, a nominally significant single-marker association of SNP rs600753 with spelling was identified in German dyslexia families ( Matsson et al. , 2015 ).

Of the 1589 remaining regions, 250 show a nominally significant r g between AD and stroke, with four of these regions including known AD loci: FERMT2 , TSPOAP1 , SHARPIN , and TNIP1 (Table S4 ).

Comparison of the two analyses identified 120 concordant lipid species, nominally significant in both analyses, including species of 18 lipid classes including ceramide, hexosylceramide, sphingomyelin, plasmalogens, alkyldiacylglycerol, and cholesteryl esters.

It seems that the results from the source dataset are informative, because 5.80% of the P -values are nominally significant at the 0.05 level ( 11 377 out of 196 018 ), 77 are significant at a false discovery rate of 5% (Benjamini–Hochberg), and 35 are significant at a family-wise error rate of 5% (Holm–Bonferroni).

The variant allele of ABCB1 3435C>T (rs1045642) had an additive protective effect against cardiotoxicity in breast cancer patients treated with anthracyclines ( 43 ), and the results remained nominally significant after adjustment for clinical covariates.

Family relationships Quality of the relationships, neglect, maltreatment and violence None of the variables in this subgroup reached significance after Bonferroni’s corrections – some of them reached only a nominally significant difference, considering the average age of onset of crack-cocaine use between groups.

For models showing nominally significant interactions between GAD subgroup and time, estimated marginal means were computed and used to examine linear trends within groups and differences between groups in connectivity slopes from baseline to 2-year follow-up using the emmeans package ( 74 ).

9 Endothelial cells were also nominally significant in our study for SBP and Bonferroni significant for DBP.

Several genetic loci showed nominally significant association with PTSD ( PARK2, CUB, CSMD1, DOCK4, ABCA8 , and C3orf8 ), although none of them reached a genome-wide significance.

To enrich for potential additional relevant patterns, we graphed median effect sizes for nominally significant ( p unadj <0.05) gene/trait associations alongside the significant gene/trait associations (as denoted by asterisks, Fig. 4B ).

Additionally, any p-value falling between 0.05 and the Bonferroni-corrected p-value was considered nominally significant.

The rule uses the hazard ratio of a time to event outcome such as all-cause mortality or event-free survival and indicates stopping the trial for safety concerns if the hazard ratio is nominally significant at a pre-specified level.