“nominally significant”

Additionally, at a nominally significant level, we also detected some probably causal relationship.

ACT comparison, the following genes were nominally significant at FDR < 0.05: SQLE (log 2 FC = +3.02, p adj = 0.008), ACACA (log 2 FC = +1.18, p adj = 0.004), HMGCR (HMG-CoA reductase; log 2 FC = +1.49, p adj = 0.033), and LDLRAP1 (log 2 FC = +3.05, p adj = 0.049); at the relaxed FDR < 0.10 threshold, CETP (log 2 FC = −1.29, p adj = 0.094), PPARG (log 2 FC = −1.34, p adj = 0.083), SCD5 (log 2 FC = +1.19, p adj = 0.100), and FASN (log 2 FC = +0.95, p adj = 0.059) were additionally flagged.

Serum 3-DG concentrations correlated with smoking which was highly significant in the KORA sample, with the same direction nominally significant in BiDirect, and significant in the meta-analysis.

Six SNPs yielded nominally significant associations across the normal distribution of g, of which only one remained significant after correction with a false discovery rate of 0.05.

The χ 2 likelihood ratio tests (Table 5 ) identified four interaction terms as nominally significant between SNPs in AXIN1, DAAM1, DKK2, WNT3 and WNT6 .

Among 40 SNPs showing nominally significant main effects, MeHg interactions with IQ scores were detected for paraoxonase 1 ( PON1 ), progesterone receptor, transferrin and brain-derived neurotrophic factor.

The linked class I HLA-B*38:01 and HLA-C*12:03 alleles showed a nominally significant protective effect, which is in line with a previously described protective effect of HLA-B*38:01 in a very large European study [ 17 ].

We found 3 out of 6 to be an eQTL as well in at least one cell type albeit one with nominally significant effect.

The findings described above were confirmed by Genevar, which revealed a nominally significant cis -directed DAE for IL13 in the MuTHER pilot project ( Figure 3 ).

We found that the causal effect values of the three microbiome features of the same family Coriobacteriaceae and eczema were nominally significant ( Table 1 ).

Exclusive cannabis use compared to combined cannabis and tobacco showed no significant difference in DNA methylation ( p = 0.48). Discussion Here we report a nominally significant association between cannabis use during pregnancy and increased DRD4 promoter methylation at one CpG site (CpG11:636796, hg38) in infants, which remained after adjustment for concurrent tobacco use.

This effect was removed from the estimated sleep duration–brain volume relationships by covarying for ICV, which may contribute to explaining why the nominally significant relationship between TGV and sleep duration in the MR analysis did not survive corrections.

Nominally significant treatment effect modification was detected for age (interaction p-value 0.042), with the estimated treatment effects being stronger in patients aged 70 years or younger, aHR 1.20 (95% CI; 1.13, 1.28) than in relatively older patients, aHR 1.10 (95% CI; 1.04, 1.17), and for history of CVDD (interaction p < 0.001) (Table 4 ).

A meta-analysed SNP with a p -value < 5 × 10 −8 was considered to be GWS, while SNP with a p -value < 0.05 was considered to be nominally significant.

The minimum LRT statistic across all samples was 279, which would be nominally significant evidence for contamination, but which we believe reflects a weakness of our multinomial model.

For other association analyses, a Hochberg step-up procedure was used to determine statistical significance while maintaining overall type I error at 5% in the context of multiple comparisons; a p < 0.05 was considered nominally significant [ 25 ].

14 , 15 In the EVOLVE trial, cinacalcet led to nominally significant decreases in the risk of death or first myocardial infarction, hospitalization for unstable angina, heart failure, or a peripheral vascular event. 14 Furthermore, in the ADVANCE trial, cinacalcet combined with vitamin D decreased vascular and cardiac valve calcification scores. 15 Cinacalcet can re

Other probes with nominally significant p-values (<0.05) (not passing FDR) and outlier fold changes included those mapping to desmocollin 1 ( DSC1 ), a cadherin protein involved in epithelial cell adhesion in desmosomes [27] , which had the highest fold change [ Figure S2C ].

Unless otherwise specified, pathways with FDR < 0.05 were considered significant, and those with P < 0.05 but FDR > 0.05 were reported as nominally significant and interpreted with caution.

TCHHL1 was identified in a genome-wide association study (GWAS) to have a significant association with hair shape within the top-associated single nucleotide polymorphisms (SNPs) (rs17646946), and showed nominally significant association with hair curliness [ 47 ].

Our ostensible ‘true negatives’ may well have exhibited shared genetic architecture within the MHC but not to an extent, within or without the MHC, sufficient to induce a nominally significant genetic correlation.

They found an enrichment of rare non-coding CNVs near known epilepsy genes, with the GABRD gene showing the strongest and only nominally significant association with 4 non-coding deletions amongst the epilepsy patients.

P value of less than 0.05 was considered nominally significant.

However, as there were nominally significant differentially abundant ASVs, we investigated whether they could be used to construct classifiers to predict high vs. low tumor T cell infiltration from fecal samples.

Although we observed nominally significant longer sleep latency and decreased REM sleep ratio in FMD, these results were no longer tenable with the chosen adjustment for multiple comparisons.