“nominally significant”

Results We identified nominally significant associations between 85 gut microbiomes taxa in EAS and 64 gut microbiomes taxa in EU with stroke or its subtypes.

It is interesting to note that the recently reported Genetic Association Information Network (GAIN) consortium study of recurrent depression reported nominally significant evidence for association at CACNA1C, 24 although it is important to recognize that the genotyping platform (and hence, single nucleotide polymorphism set) differed from that used in the WTCCC analysis.

GWAS-Catalog Lookup We performed a lookup of all nominally significant SNPs and genome-wide significant genes identified from GWAS as described in Section 2.3 in the EMBL-EBI GWAS catalog (summary statistics downloaded on 1 October 2022) [ 30 ] to identify the known associations of SNPs and genes from our study with other phenotypes.

The seven nominally significant CNVs have all, at least partially, been reported by the Database of Genomic Variants (DGV, http://dgv.tcag.ca/dgv/app/home ; Macdonald et al ., 2014 ), supporting that they represent true findings.

For each transcript, we counted the number of experiments where the significance for differential expression was ≤0.05, and then generated the binomial probability, referred to as the consensome p-value (CPV), of observing that many or more nominally significant experiments out of the number of experiments in which the transcript was assayed, given a true probability of 0.05.

Results with uncorrected P < 0.05 but exceeding the corrected threshold (i.e., P ≥ α’) were considered nominally significant but not statistically significant after correction.

Nominally significant effects on insulin sensitivity could be found for MADD and PROX1 .

Considering the gene–gene interactions (G × G), the results showed nominally significant in the Asian group the MAFB gene SNP rs17820943 interacted with the PAX7 gene SNP rs4920520.

We did not find any significant association, although TREM2-carriers showed nominally significant lower levels of the ENST00000373122 transcript (shorter, transmembrane protein) compared to controls (Fig. 2 and Table 5 ).

After FDR correction, most nominally significant subgroup associations between physical activity and ln(HbA1c) were attenuated.

Later sleep onset after sex ( B = 0.339 hours, P = .005) was nominally significant but did not pass the stringent correction for multiple comparisons.

[ 82 ] Yang et al ’s [ 83 ] study identified a nominally significant interaction between body mass index (BMI) and rs11903757 (2q32.3/NABP1) in colorectal cancer risk.

Prior to multiple testing correction, three SNPs (rs10416533, rs7251432, rs55863037) exhibited nominally significant associations with parameters of iron and glucose metabolism.

The results indicate a nominally significant causal association, consistent with a higher risk of CAD being associated with a 7% higher risk of LOAD (OR 1.07 for LOAD per log odds unit of CAD [1.01–1.15]; p = 0.027).

Results Breast cancer was increased in women with POI (OR, 2.20; 95% CI, 1.30-3.47; P = .0023) and there was a nominally significant increase in ovarian cancer.

For example, risk allele frequencies in PLD3 in controls of one cohort may be higher than that of cases in another cohort, while combined result may be nominally significant ( 77 ) or not significant at all ( 87 – 89 ).

The SNP rs13058434 (p.P177L) showed nominally significant association with BMAF in the subgroup of children who were not-at-risk according to rs133885 genotype.

[ 3 ]) and tested in our analyses; we observed an enrichment of nominally significant associations with concordant direction of effect: 20.3% variants (16/79) in the AD + LB − vs.

Any gene knockdown that showed a nominally significant change of growth density (α = 0.05) at least one of these three distances was defined to significantly regulate NOG.

Heatmaps were generated using row-scaled (z-score) expression values for all nominally significant proteins ( n = 31) or the top 20 proteins ranked by raw p -value.

KEGG Level 3 pathway analysis revealed multiple nominally significant functional differences between the two groups, which are summarized in Figure 4 .

rs237897 (nominally significant in male subjects) and rs9840864 (nominally significant in female subjects). 6 of the 8 htSNPs showed a consistent association for both Dictator Game and SVO allocations.

41 GWAS results for SRE remain inconclusive so far due to relatively small sample sizes but have included nominally significant associations between initial alcohol sensitivity and a genetic marker in GABRA6 . 44 Several studies have also identified associations between alcohol dependence and GABAergic SNPs on chromosome 4 ( GABRA2 , 33 , 45–50 GABRA4 , 16 GABRB1 , 51 GABRG1 42 , 49 ) and chromosome 5 ( GABRA1 , 43 , 52 GABRA6 , 53 , 54 GABRG2 33 , 55 ).

Associations of SNCA, GBA1, and UGCG Expressions with Depression Severity and Anxiety Based on the elevated gene expression levels observed in depressed patients compared to unaffected individuals, we conducted an exploratory analysis to determine whether high gene expression levels correlated with depression severity as assessed by clinicians (HAM-D, MADRS) or self-evaluation (BDI-II) with subsequent sex-stratified analysis in the event of nominally significant effects.

Polymorphisms g.270 C>T (genotype GT) and g.678 G>T (genotype GG) showed a nominally significant association with faster disease progression when all animals from both cohorts were considered.