“nominally significant”

Nominally significant improvements in rPFS, ORR, and OS, were reported for the olaparib group compared with the control treatment group for the Cohort A ctDNA subgroup; these improvements were comparable with those that have previously been reported for the 245 patients from the overall Cohort A ITT population with BRCA/ ATM alterations identified by prospective tumor-based NGS testing ( 4, 5 ).

3 , which includes all observed nominally significant associations (all ps < 0.05).

One locus was nominally significant in the independent cohort but did not survive the multiple testing correction (rs35866622, p_replication = 0.0037).

However, considering that our significant or nominally significant OR is close to 1, our results are suggestive and need to be treated with caution.

The explanatory power of the PRS was close to zero in both cases (~0.02% in the pilot study; ~0.01% in the current study), but the association in the pilot study was in the opposite direction compared to the new result for ASD, and the latter was at least nominally significant, unlike the former result.

A nominally significant interaction between TL and time for right temporal volume did not survive FDR correction in the full sample, but in HC, the same structure unexpectedly decreased less over time as the CE and TL scores were higher (personality x time-interaction effects), even after FDR correction.

The SNPs showing the largest allele frequency differences between low- and high-ability groups were tested in an additional follow-up cohort of 4258 children, finally identifying 10 SNPs showing nominally significant associations with continuous variation in reading ability 34 .

Only nominally significant associations were detected between gene expression and ppFEV1; however, these include multiple biologically plausible targets.

In our latest study, height-increasing alleles at all 606 height-associated variants (Exome Chip data) were enriched for nominally significant protective effect on several cardiometabolic traits: total cholesterol (TC; P binomial = 4.4 × 10 −8 ), triglyceride (TG; P binomial = 8.9 × 10 −7 ) and coronary artery disease (CAD; P binomial = 6.0 × 10 −10 ).

There was a slightly excess of heterozygotes and a deficit of GG homozygotes among CAD patients in the North-American cohort, resulting in a nominally significant deviation from Hardy-Weinberg equilibrium (HWE) in this group (Table 3 footnote).

Covariation for total energy intake did not change the association between ARFS and lipids, with TGs still the only nominally significant association with ARFS.

SNPs at the EEFSEC locus showed nominally significant dominant effects ( P .dom < 0.05) ( Table S7, S8 ).

None of the genotyped SNPs mapping to these genes, including the previously implicated SNPs rs2653349 (G1246A) in HCRTR2 and rs1126671 in ADH4 , reached a nominally significant P -value (Additional file 1 : Table S3).

On the basis of data from 40,853 individuals with NDDs, we report a nominally significant excess of de novo variants within 29 genes that are not implicated in NDDs, including 3 essential genes ( G3BP1 , G3BP2 , and UBAP2L ) in the core SG interaction network.

1 , 3–5 Most importantly, four different long-acting GLP-1RAs (liraglutide, albiglutide, semaglutide and dulaglutide) have been found to the reduce risk of future major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal myocardial infarction and stroke) in patients with T2D, with the other long-acting GLP-1RAs, exenatide once-weekly (exeOW) showing a trend towards reduction in MACE combined with a nominally significant reduction in overall mortality. 6–9 When combined together in a meta-analyses, cardiovascular outcome trials on GLP-1RAs have showed efficacy in reducing occurrence of cardiovascular and renal outcomes (progression of albuminuria), and of overall mortality. 10 The outstanding results on cardio-rena

Comparisons that were nominally significant but did not survive FDR correction.

We explored the derived network representations under the following questions: (i) are there nodes that deserve consideration regarding their network connectivity characteristics? (ii) What is the relation of either the genome-wide or nominally significant CM polymorphisms/genes with the ones highlighted by the network representation?

Both GO terms and KEGG pathways with a p -value < 0.05 were considered nominally significant. 4.7.

Similar to previous analyses with these data, 92.3% of the reported differentially spliced genes associated with AUD 7 , were at least nominally significant in our analyses.

Although associations between AZ and alanine aminotransferase (ALT, 0.087; 95% CI: 0.012–0170; p < 0.05), FE and albumin (ALB, 0.067; 95% CI: 0.001–0.132; p < 0.05), FLUO and alkaline phosphatase (ALP, 0.091; 95% CI: 0.005–0170; p < 0.05), and indirect bilirubin (IBIL, 0.077; 95% CI: 0.002–0151; p < 0.05) were nominally significant, they should be interpreted with caution, as they did not survive multiple testing correction and may represent false positives or require validation in larger, independent cohorts.

Using the COLOC R package v5.2.3 67 , we performed Bayesian colocalization on 9144 candidate variants against nominally significant eQTLs from 13 brain tissues in the GTEx v8 dataset.

Three SNPs, rs2278493 in hexokinase 3 ( HK3 ), rs2234693 in estrogen receptor 1 ( ESR1 ) and rs12611091 in BR serine/threonine kinase 1 ( BRSK1 ), showed nominally significant association with POI.

(2012) provided results for 74 nominally significant CpGs (part of their top 100 findings) representing 69 gene regions that did not meet their strict criteria for genome-wide significance (Bonferroni correction, p < 1.06 × 10 –7 ).

Nominally significant ROIs included the sagittal stratum , overall corpus callosum, genu of the corpus callosum, retrolenticular part of the internal capsule, and the fornix (crus)/ stria terminalis (FX/ST).

Further fine-grained analysis, using a sliding 100 kb window across the locus, implemented for three nominally significant SNP-dense loci (number of SNPs >1,000) reported two regions with significant h 2 observed for both total protein and PND, located sequentially within the 5q13.3 locus and implicating IQ motif-containing GTPase activating protein 2 ( IQGAP2 ) ( Table 1 ; online suppl.