“nominally significant”

Nominally significant associations (raw p value) were considered.

Two SNPs in CRY1 were shown to have nominally significant correlations with the risk of fatal disease in HPFS and AGES-Reykjavik within the respective cohorts.

Of all the variants, 61.9% (26 of 42) showed a higher effect on PA than on hypertension, and its proportion increased to 80.0% (8 of 10) when limited to those with nominally significant differences in effects between PA and hypertension (Figure 3 B; Excel File S1 ).

Further, although AOX1 haplo-type 100000 (G–A–T–G–A–G) also has a nominally significant p -value under a recessive model, it has a protective effect.

Mucin-16 (MUC16), also known as CA125, a well-known OC tumour marker, was initially associated with a higher risk of OC and its subtypes in our study at the nominally significant threshold.

After adjusting for multiple testing (four cancer traits and three strata) we detected an increase in the enrichment parameter for SCZ given lung cancer ranging from 1.424 (−log10pval >1) to 2.190 (−log10pval >2), and 6.512 (-log10pval >3) of which the first stratum is significantly enriched after multiple testing correction, and the second stratum is nominally significant (Supplementary Table 2 ).

The PSE group had lower MD in the splenium of the corpus callosum compared to unexposed controls, and a nominally significant difference of MD in the IFOF that did not survive FDR correction.

P-values between 0.05 and the specified threshold were considered nominally significant. 2.4.2 Mediation analysis The two-step univariable mediation MR analysis was implemented to investigate whether brain cortical structure mediates the causal pathway from insulin resistance to cognition outcome.

P values were given to assess nominal strength and were considered nominally significant at the 0.05 alpha level.

Discussion In this study, some of the variants related to psychiatric traits showed nominally significant association with sleep.

However, to prioritize our results for interpretation and future studies, associations with p values less than or equal to 0.01 were considered significant, whereas associations with p values less than 0.05 were considered nominally significant. 3.

Suggestive MR Associations Several micronutrients showed nominally significant associations with T1D risk in our MR analysis ( Table S2 ).

Altogether, nominally significant associations between the rs2149954 minor allele and a decreased risk of heart attack and heart failure as well as increased physical functioning were found in the long-lived individuals.

No regions with significant correlation were identified after Bonferroni correction, while regions with nominally significant correlation were found between ALS and MS, IBD, SLE, CD, UC, and RA (Additional file 1 : Figure S1).

found a nominally significant association between HLA-DQB1*03:01 and colitis, in other words, carriers of which were susceptible to colitis during immunotherapy ( 81 ).

The IVW method meta-analyzed SNP-specific Wald estimates using random effects to obtain the final estimate of the causal effect ( Burgess et al., 2019 ), which was reported in beta (β) value with standard error for continuous outcomes and odds ratio (OR) with a 95% confidence interval (CI) for binary outcomes; P -values < 0.05 were considered nominally significant.

Model 3), the mid-to-late adulthood NSD association was reduced for g intercept but remained nominally significant for slopes of g and processing speed ( Supplementary Table 7 ).

One nominally significant locus, mapping to ACER1 on chr 19, was identified for both COT and COT+3HC.

We estimated the rate of ‘replication’ or the number of times an association appeared to be nominally significant at a P value threshold of 0.05 in greater than one survey sampling, which we call a ‘replication rate’.

While four genes, Rab1 , Atg8b , Vamp7 and Rac1 (the first three are involved in both phagocytosis and autophagy pathways, whereas the last is implicated only in phagocytosis) showed nominally significant D , EW , and DHEW statistics, none remained significant after the multiple testing correction.

For example, while the associations with the prescribed food supplements were nominally significant and robust to adjustment for ATC-based indication proxy, we cannot exclude a potential role of ascertainment bias in these results.

The expression of 48 genes was associated with FSI, of which 11 remained nominally significant after adjustment for BMI, whereas 19 genes were associated with FPG, of which two remained nominally significant after adjustment for BMI.

However, nominally significant results for the educational attainment, memory, and RT phenotypes showed enrichment of central nervous system tissue types.

However, the rs9934336 SNP had a nominally significant effect on glucose concentrations and insulin levels in individuals without diabetes in both the main and the control group.

Next, we took 3,844 unique genes with at least one nominally significant sQTL in HCASMC or HCAEC and tested those for sQTL using GTEx artery tissues.