“nominally significant”

When the rs1800532 variant was selected for attempted suicides, the heterogeneity decreased slightly (from 62.5–60.7%) and the pooled ORs showed a nominally significant harmful trend for the minor allele (1.22 (1.05–1.41), P =0.007, power of 99%) ( Figure 5 ).

For four of the known GWAS SNPs the associations in our African American breast cancer data had a nominally significant p-value less than 0.05 ( Table S4 ), namely rs13387042 at 2q35 (OR = 0.89; 95% CI = 0.82–0.97; p = 0.00713), rs865686 at 9q31 (OR = 0.92; 95% CI = 0.85–0.99; p = 0.0287), rs2981582 at 10q26 (OR = 1.11; 95% CI = 1.03–1.19; p = 0.0087), and rs2363956 at 19p13 (OR = 0.88; 95% CI = 0.82–0.95; p = 8.1×10 −4 ).

Notably, after 4 hours of IL-12 treatment, the most significantly up-regulated gene was IL18RAP (average 2.37-fold, FDR p = 1.0 × 10 −13 ), which also manifested a nominally significant effect of TYK2 genotype (ANOVA p = 7.2 × 10 −3 , Table S10 ).

This SNP is a significant ( p = 4.78 × 10 −8 ) expression quantitative trait locus (eQTL) for DIAPH3 , which was a nominally significant ( p = 7.23 × 10 −3 ) SLE risk locus in a previous GWAS study ( Lee et al., 2014 ).

7 h), it was nominally significant prior to correction ( p ≈ 7.3e − 3 ), indicating that while disease-related genes remain partly anchored to mid-level regulatory layers, they tend to extend into functional endpoints.

The differences in decrease were nominally significant in favor of intravitreal aflibercept for 2q4 versus Rq4 and 2q8 versus Rq4 ( P = 0.0075 and P = 0.0126, respectively).

More rapid reductions in NfL levels were observed in the 50/28 mg group (88%) compared with the 12/12 mg group (77%) at day 64 (nominally significant P = 0.0075; joint-rank test) (Fig. 2b ).

Additionally, we identified two nominally significant correlations: the EQ with subjective well-being ( r g = 0.19 ± 0.07; P = 7.8 × 10 −3 ) and NEO-conscientiousness ( r g = 0.39 ± 0.14; P = 8.8 × 10 −03 ) (Fig. 3 ).

Inspection of COVID-19 disease severity outcomes, including admission to intensive care, reveal nominally significant risk associations with A*11:01 (FET p = 0.0078) and C*04:01 (FET p = 0.0087).

There was a nominally significant effect of phenotype definition on cortical volume associations in the temporal lobe (z = 0.035, SE = 0.013, p = 0.008), but this did not survive correction for multiple comparisons.

While two of the 13 DMPs at birth also showed nominally significant effects at age 7 (cg27469152 located in the gene EPX ; β stdn = -0.090; p = 0.008; and cg16290904 located in the gene PEX2 ; β stdn = -0.077; p = 0.022; Table 1 ), no probe remained significant after FDR-correction for 13 test.

For multivariate models (CSS–multi, OS–multi, DFS–multi), Begg’s tests were non-significant and trim-and-fill did not impute additional studies (all k 0 = 0); although Egger’s test yielded a nominally significant P value for DFS–multi (P = 0.008), the absence of imputed studies and the similarity between original and adjusted estimates suggest that any small-study effects are unlikely to materially bias the results.

One rare single-nucleotide polymorphism (SNP), HugotSNP8ms2 (minor allele frequency <0.05), showed nominally significant deviations from HWE in the controls ( p = 0.008) and in the full sample ( p = 0.006) due to an overrepresentation of rare homozygotes, which might be the result of chance or genotyping error.

In the fully adjusted bifactor model, the association between greater SVD burden and declining general cognitive ability was nominally significant ( p = 0.008), but became non-significant after FDR correction (p FDR = 0.085).

Notably, rs192471919 had a nominally significant association ( P = 0.008), with same effect direction in Jansen et al. 3 where it was present only in the PGC-ALZ cohort (n = 16,350).

Although not surviving multiple testing, a nominally significant association was found between salt intake ≤6 g/day and presence of chronic axonal polyneuropathy (OR = 0.55, 95% CI 0.35; 0.86, P = 0.008).

Its association with knee OA is weaker but nominally significant (OR 0.90 (95% CI 0.83 to 0.98), p = 0.008).

PPARγ showed one nominally significant correlation with Stroop-2 ( r = 0.215, p = 0.008) that did not survive FDR correction (q = 0.24).

Differences in drop seizure reduction between placebo and CBD emerged during the titration period and became nominally significant by Day 6 ( p = .008) for pooled CBD treatment groups.

The 0.901-second (95% CI 0.237 to 1.565) difference at 24 weeks was nominally significant (unadjusted P =.008) but did not survive Bonferroni correction.

Additionally, in NAS score analysis in this region, we detected a novel eQTL marker for HSD17B13 (rs3923441) that was nominally significant with NAS score ( p = 0.008, beta = 0.55) (Additional file 1 : Table S3) and produced a PheWAS effect for abnormal liver enzyme levels (see the “ PheWAS approach ” section).

Adjusting for baseline characteristics yielded a 12% reduction in risk of death or nonfatal cardiovascular events (relative hazard 0.88, 95% CI 0.79 to 0.97) that was nominally significant ( P =0.008).

While far from genome-wide statistical significance for gene-based testing ( p < 2.7 × 10 −6 ), we found nominally significant associations of the predicted damaging CCR2 variants with myocardial infarction (OR: 0.60, 95%CI: 0.40–0.90, p = 0.008) and coronary artery disease (OR: 0.76, 95%CI: 0.59–0.99, p = 0.03), as well as directionally consistent associations with the odds of all other examined outcomes (ischemic stroke, peripheral artery disease, abdominal aortic aneurysm, Fig. 2 A).

Claude Opus 4.6 showed a nominally significant decline ( p = 0.0081) that did not survive correction.

In addition, rs5745752 appeared nominally significant (OR 1.58, 95% CI 1.19–2.09) (p = 8.1×10 −3 ) with associated increased risk of KC ( Table 2 ).