“nominally significant”

Similarly, the core spliceosome element Sf3b1 did not show any alterations in brain expression levels either during developmental phases or during ageing, with the exception of a single nominally significant reduction in expression of Sf3b1 in the 13–15-year-old group (beta coefficient: − 0.275; p = 0.006; Supplementary table S6 ).

( 2012 ), we find 450 in the genome in autism; compared to this, four hits in our gene set reflect a nominally significant enrichment (3.6 fold; p = 0.006, Poisson test).

A single nominally significant association was observed for EDSS: horizontal smooth pursuit velocity error (ρ = 0.41, p = 0.006, q = 0.35, adjusted for age and baseline EDSS), which did not survive FDR correction.

Nominally significant interactions ( P = 0.006–0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci ( GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci ( LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjusted WHR or BMI outcomes.

Between-group treatment differences were nominally significant for UPDRS Part II ( p = 0.006) and CGI-C ( p < 0.001) at Week 26 in favor of LCIG; however, statistical significance could not be claimed in light of primary efficacy outcomes.

Metabolites Associated With DR We found 17 metabolites associated with DR without adjustment for confounding factors; 7 of them were statistically significant ( P < 5.0 × 10 −5 ) and 10 nominally significant ( P < .006) after the adjustment for confounding factors.

Of the three loci identified in the main analysis, the locus on chromosome 11 was nominally significant in the Chinese cohort ( P = 0.006, Supplementary Fig. 8C ).

The average call rate was 97% and one SNP had nominally significant (p < 0.006) deviation from Hardy-Weinberg equilibrium (Table 1 ).

The SECA primary test for the overlap of associated effects, including all 144 SNP subsets, revealed more subsets than expected by chance showing at least nominally significant pleiotropy between endometriosis and endometrial cancer ( P = 6.0 × 10 −3 ): The pair of SNP subsets producing the minimum exact binomial test P ‐value for pleiotropy (endometriosis SNP subset with P ≤ 0.002 and endometrial cancer SNP subset with P ≤ 0.86) had P = 3.3 × 10 −4 .

Again using the thresholds ( p value <0.05 and Δβ ≥ 0.1) analysis revealed one nominally significant mQTL for FAM63B_1 (rs4774353 in FOXB1 , chr15:60309674 (hg19), with p value = 0.006 and Δβ = −0.11 for the A allele).

However, the study reported a nominally significant reduction in the rate of exacerbations (rate ratio 0.58, 95% CI 0.39–0.85; p=0.0061) and improved lung function among former smokers with itepekimab versus placebo [ 159 ].

Unlike singleton disruptive variants, although the burden of rare disruptive variants in SCZ was nominally significant, and survived FWER correction for all tests within the trait, it did not meet the threshold for tests across all traits (unadjusted P =0.0061, FWER within P =0.0228, FWER across P =0.0863, Supplementary Table S9 ).

In addition, damaging or rare damaging NOD2 variants were nominally significant across all three burden tests applied (p = 0.0063 to 0.045).

We also observed nominally significant results in relation to SCZ: a positive correlation between SCZ GWAS results and HB scores for complete selection (p = 6.37*10 −3 , S1 Table ; permutation p = 3*10 −3 , S2 Fig ).

Nonetheless, the lead SNP at the PAX1 locus showed a nominally significant interaction (β_int = 0.0309, P = 6.6 × 10 − 3), mirroring the direction and significance of the heterogeneity statistic.

The radial glia-like cells (RGCs) in the subventricular zone (SVZ-RGCs, p = 0.0035), RGCs in the dentate gyrus (DG-RGCs, p = 0.0261), and oligodendrocytes (p = 0.0306) showed nominally significant enrichment in the cell-specific enrichment analysis ( Figure 4 B), of which DG-RGCs were also nominally significant (p = 0.0066–0.0484) in three robustness analyses ( Table S10 ).

Specifically, tumors from chemosensitive patients showed nominally significant enrichment in natural killer (NK) cells ( p = 0.0069, BH adj. p = 0.1596), CD4+ Th1 T cells ( p = 0.0089, BH adj. p = 0.1596), and CD4+ non-regulatory T cells ( p = 0.0290, BH adj. p = 0.3423).

Of note, a signal near SLC26A9 , a known cystic fibrosis modifier gene 54 , was highly significantly associated with PEF in UK Biobank (P=3.97×10 −66 ) and nominally significant in SpiroMeta (P=6.93×10 −3 ), with consistent direction of effect, but did not meet the Tier 2 criteria.

Results Global Bivariate Genetic Correlations We identified weak, nominally significant inverse global genetic correlations between smoking initiation and IOP (r g = −0.06, SE = 0.02, P = 0.007), AI-vCDR (r g = −0.04, SE = 0.02, P = 0.02), and mGCIPL (r g = −0.07, SE = 0.03, P = 0.02).

Fecal 16S rRNA analysis (rosacea n = 18, controls n = 265) identified 15 nominally significant genera, including depleted Bifidobacterium ( p = 0.007), Roseburia ( p = 0.033), and enriched Anaerostignum ( p < 0.001).

Nominally significant results were observed in individual CpG sites for loss of a parent or caretaker (CpG4 β: -0.719 [-1.239, -0.199], p-value = 0.007 and CpG5 β: -0.626 [-1.237, -0.015], p-value = 0.045).

SNP rs2894439 near FOXP4 demonstrated nominally significant association (Additional file 1 : Table S9-S10, one-sided P = 0.007) in Whites, with increased frequency in Columbia ILD cases (MAF = 0.048) compared to matched controls free of ILD in MESA (MAF = 0.021).

In the Blackface lambs, there was a nominally significant association (P = 0.007) between IL23R p.V324M and weight at 20 weeks.

ER− breast cancer showed a nominally significant IVW association (OR, 1.04; 95% CI, 1.01–1.08; p = 0.007), although sensitivity methods did not reach significance.

When the rs1800532 variant was selected for attempted suicides, the heterogeneity decreased slightly (from 62.5–60.7%) and the pooled ORs showed a nominally significant harmful trend for the minor allele (1.22 (1.05–1.41), P =0.007, power of 99%) ( Figure 5 ).