“nominally significant”

While both age at sampling and disease duration > 12 months had nominally significant p ‐values, the only statistically significant predictor of time to minimal disease manifestation, after correction for multiple testing, was elevated CD4 T cell frequency ( p = 0.0014, HR = 0.94, 95% CI: 0.91–0.97).

Nominally significant DEGs were subjected to GO enrichment analysis.

However, individuals in the prototypic cluster were more often affected by a comorbid lifetime MDD (nominally significant), reported higher BDI scores, and had higher score on the suicidality-item I of the BDI.

When altogether 77 common variants were considered individually, we found nominally significant interactions between five variants and CHEK2 *1100delC for overall breast cancer (rs11249433, rs11780156, rs204247, rs2981582 and rs704010; Table S4a ).

The follow-up study included 121 SNPs that produced p-values <10 −4 in the GWAS, as well as 19 nominally significant SNPs from genes of which homologs had shown expression changes in rat brains in response to alcohol consumption.

The most pronounced nominally significant difference between CA and AA centered on the right amygdala.

While many proteins were nominally significant, adjusting for FDR suggested insufficient evidence to assign importance to any protein, confirming the need for more advanced feature selection methods ( Fig 2B ).

Shn2 KO mice exhibited a significant reduction in GluR1 expression and a nominally significant decrease in SV2 expression, while PSD95 expression had a non-significant tendency to decrease in Shn2 KO mice.

The frequency of SBM, QOL, and the severity of OINV were nominally significant in the naldemedine group than in the control group.

Some studies have clustered nominally significant SNPs located within a confined distance 26 , while others have focused on a priori candidate genes 27 .

Age differences in EDR In the autistic group, nominally significant age-related differences were observed for two stimuli in SCL and two in SCR prior to correction for multiple comparisons.

BMI trajectories in SCZ cases and controls To capture BMI trajectories over time, we accounted for multiple BMI measurements per individual and additionally considered BMI PRS given its nominally significant negative association with SCZ ( Supplementary Figure S11C , Supplementary Table S3 ).

Differences were nominally significant for the 6 U/kg group at weeks 4 to 8 (elbow) and weeks 6 to 12 (wrist), and for the 3 U/kg group at week 4 (elbow) and weeks 2, 8, and 12 (wrist) ( Supplementary Table 4 ).

Therefore, we report the nominally significant reductions spanning across the frontal, temporal, and parietal lobe (see Table 2 ).

In the third ECT study, the longitudinal EWAS identified nominally significant differentially methylated positions and regions in genes implicated in psychiatric and immune-related processes, including ADARB1 and SLC25A24 .

P-values < 0.05 were deemed as nominally significant.

Of note, nominally significant associations with cognitive variables were identified, after covarying for age and diagnostic status.

An initial significant adverse association between statin use and thinner measures was attenuated after adjustment for BMI, systolic blood pressure, diabetes, and cardiovascular disease (although for mRNFL, the adverse association remained nominally significant).

Considering that the eQTL model was constructed from the European(EUR)population and that the flora-associated GWAS summary data were from the EAS population, this part of the study focused only on nominally significant genes, i.e., those with uncorrected P < 0.05. 2.6 Functional enrichment analysis For a given set of genes, pathway enrichment analysis was performed via the clusterProfiler (v.4.2.2) and ReactomePA (v.1.38.0) software packages on the basis of the Gene Ontology (GO), KEGG, and Reactome pathway databases [ 47 , 48 ]. 3.

For the EstBB replication set ( n = 92,645 individuals), 99.0% of the 2,019 available variants showed the same direction of effect, and 91.3% of these effects were nominally significant.

Here the nominally significant findings may be considered as in the context of low power to detect the relatively weak association expected at a marker in a complex genetic trait like musical aptitude [40] .

However, almost all had a family history of breast or ovarian cancer, and after allowing for these factors the effect of age at testing was no longer nominally significant.

However, it was illustrative to identify both NAA38 and LSM3 among the nominally significant dysregulations, given that ATXN2L and both factors mentioned are members of the Lsm protein family and that LSM12 was previously reported as an ATXN2L interactor [ 82 ].

A nominally significant improvement in MMN was observed, suggesting that luvadaxistat 50 mg (vs. 500 mg) can improve this illness-related circuitry biomarker at doses associated with partial DAAO inhibition [ 116 ].

Though in 2013 the relationship is nominally significant, a more rigorous analysis indicates that there is a 15% probability that it may result from measurement error.