“nominally significant”

The MR-JTI association of EIF2AK4 was specific to predicted gene expression in the vagina although it should be noted that the JTI analysis showed nominally significant associations in both uterus and ovary (Supplementary Table 6 ).

We note, however, that we did observe nominally significant associations with several previously reported and newly identified POAG risk loci in this group.

So far, only a few MR studies explored the role of 25(OH)D in cognitive function 44 , major depression 45 , and Alzheimer’s disease 20 , 21 ; and nominally significant findings have only been reported in Alzheimer’s disease.

3.2.2 Better-performing cognitive cluster Several nominally significant associations were initially observed in the better-performing cognitive cluster, including interactions involving APOE , PICALM , age, and education.

In the same tramiprosate study, the effects on the APOE3/4 heterozygote subjects showed nominally significant effects on the composite cognitive/functional Clinical Dementia Rating-Sum of Boxes (CDR-SB) [ 47 ], but the cognitive effects were less pronounced.

The explained variances of the four loci that showed nominally significant association with BMI ( TMEM18 , PCSK1 , BDNF and MAP2K5 ) were larger (0.12–0.21% versus 0.01–0.15%) in Chinese than in Europeans ( Table 1 , Figure 1C ).

Additionally, we performed a detailed examination of MAPT , GRN and C9orf72 across subtypes and observed nominally significant differentially methylated CpGs in variable positions across the genes, often with unique patterns and downstream changes in gene/protein expression in mutation carriers.

Genome-wide association study (GWAS) performed on 3,002 individuals (1,652 cases and 1,350 controls) of the German population, showed a nominally significant effect with a p -value of 0.02936, OR referring to the minor allele (T) = 0.82, CI = 0.69–0.98.

In secondary analyses, we stratified participants by treatment arm; if the interaction P value was nominally significant, only stratified analyses were considered.

Secondary Endpoints Change from baseline to Day 15 in 24-hour cough frequency Nominally significant placebo-adjusted reductions from baseline in 24-hour cough frequency were also observed at Day 15 in the 50 mg and 200 mg camlipixant arms, −32.4% (95% CI, −48.1 to −11.8; P = 0.0040) and −34.3% (95% CI, −49.9 to −14.0; P = 0.0024), respectively ( Figure 3A and Table 2 ).

The most consistent signal involved the immunoregulatory CD56 bright CD16 − NK cell subset, which showed nominally significant positive correlations with the d-GRS across two independent parent gate representations, the percentage of viable DAPI − cells ( ρ = 0.444, 95%CI [0.158–0.661], p = 0.004, n = 41) and the percentage of CD45 + leukocytes ( ρ = 0.342, 95%CI [0.038–0.588], p = 0.029, n = 41; Figure 1 B; Table 3 ).

41 We observed one nominally significant meta-analysis difference: users of ACEI combination therapy had a lower risk of COVID-19 diagnosis when compared with users of ARB combination therapy.

Note that the functional interplay between the right CeM and PAG was nominally significant at trend level.

Furthermore, offspring gender interaction analysis revealed nominally significant association between metabolites and GDM + T2DM which were significantly different in pregnancies with male versus female offspring, including the triglycerides (18:2/31:0, 16:1/36:5, 17:1/36:4, 16:0/35:3, 18:2/33:0), the amino acids/related (glutamine and ProBetaine) and the cholesterol ester CE18:3 (Additional file 2 : Figure S1).

We investigated this by a simple and interpretable orthogonal analysis, calculating the number of cell lines crossing a nominally significant RRA < 0.05 for each drug (Fig. 2b and Supplementary Data Fig. 2e ) and for each cell line (Fig. 2c and Supplementary Data Fig. 2f ).

For LAVA analysis, bivariate local genetic correlation analyses were performed for trait pairs with nominally significant univariate local genetic signals as the detection of reliable local genetic correlations requires adequate genetic variation within genomic regions.

Similarly, while ASV- and KO-based WGCNA modules did not demonstrate significant correlations with baseline metabolite levels, the KO-based green module showed a nominally significant negative association with indoxyl sulfate.

While IVW analysis revealed no statistically significant associations between autoimmune diseases and lactate levels after FDR correction, exploratory analyses using WME and weighted mode methods identified nominally significant associations between IBD or RA and lactate levels.

nrTEs that yielded nominally significant tests (pval < 0.05) at least for allele and/or genotype frequencies were considered as putatively associated with schizophrenia.

For the four p-values that were nominally significant, we performed 100,000 permutations and provided the corresponding Bonferroni adjusted, empirical p-values in parentheses.

We identified a nominally significant association of NTG with four SNPs in OPTN (rs10796021, rs3829923, rs7921853 and rs765884), three almost consecutive SNPs in the MFN2 gene (rs873458, rs2295281 and rs11588779), two close neighboring SNPs in PARL (rs1000002 and rs1402003) and one SNP in the MFN1 gene (rs2111534) (Table 2 ).

The conventional MR approach inverse-variance-weighted (IVW) method was used for effect estimates, which was reported in beta (β) value with standard error for the continuous outcome and odds ratio (OR) with a 95% confidence interval (CI) for the binary outcome; P < 0.05 were considered nominally significant.

Thus, we are only reporting nominally significant p -values for expression.

In proliferative LN, the strongest signal within PRDM1 (rs6924535, p multiethnic =0.029) and two SNVs in complete LD (rs942960, rs942961; p multiethnic =0.037) located in APOA1BP ( NAXE ) were nominally significant in the multiethnic replication cohort ( table 2 , online supplemental table S1A ).

Genome-wide linkage and association analyses in a Hutterite founder population identified several nominally significant regions on chromosomes 13, 3, 9, 5, 15, and 1, supporting its polygenic basis [ 9 ].