“nominally significant”

The effect of other covariates on PRO-PD demonstrated a nominally significant association with gender, where females had a considerably lower median PRO-PD score (665) compared to males (827.5) ( Table 3 ).

The AGFG1 result replicated at a nominally significant level in one independent population (LHS P-value 0.012), and the SNP had a nominally significant unadjusted P-value (0.0067) for being an eQTL of AGFG1 .

Mammalian Phenotype Ontology terms related to emotional behavior, cognition, anxiety, sensorimotor gating, fear, and reward were also enriched, albeit only at a nominally significant level.

From a statistically conservative standpoint, raw p -values between 0.0125 and 0.05 would be discussed as nominally significant.

Please see Tables S8-S10 for details of this process, but, in brief for h 2 , class I includes those PMs with very high (≥ 0.75) inter-rater agreement and a statistically significant (after multiple-testing correction) large (≥ 0.20) narrow-sense heritability; class II includes those PMs with nominally significant (but that do not survive multiple-testing correction) large (≥ 0.20) narrow-sense heritability with very high (≥ 0.75) inter-rater agreement; class III is like class II less the inter-rater agreement; class IV is a collection of PMs that might give some suggestive evidence of narrow-sense heritability (≥ 0.20) but without any statistical significance but with some inter-rater agreement; finally, class V collects the PMs arguably without support for narrow-sense heritability.

This association was replicated in an independent PsA cohort, but showed only nominally significant association in two independent psoriasis cohorts, suggesting that the association is specific for PsA.

However, because of the hierarchical testing strategy used for the multiple outcomes examined, the observed reduction in all‐cause mortality was labeled “nominally significant” which has clouded its interpretation.

First of all, in the Sullivan GWAS, rs2522833 only became nominally significant after post-hoc analysis with a cohort that used a similar method of ascertainment.

The GABRD gene had the strongest and only nominally significant association with four non-coding deletions among the 198 epileptic patients and none in the 301 controls.

Given the 408 MR estimations, a Bonferroni-corrected P -value of 0.05/408 (1.22 × 10 − 4 ) was determined for multivariable MR analyses, whereas P < 0.05 was considered nominally significant.

Although no formal multiple comparison computations have been done, the fact that: (1) many of the nominal p-values for associations of T1D with outcomes were at the P <.0001 level, (2) the relevant findings were all in the direction of higher risk for T1D group, and (3) the 3 composite variables were associated with the T1D with P <.0001, allow us to infer that the majority of the nominally significant findings are not due to type 1 errors.

It is important to point out that these SNPs are only nominally significant in AA or EA.

Nominally significant reductions in death from any cause and for cardiovascular causes were nonetheless observed with oral semaglutide versus placebo [ 8 ].

Given the nominally significant p.C282Y homozygote association with excess mortality (when combining men and women, aged 40 to 70 at baseline) during follow-up, we undertook post hoc analyses on causes of death.

A total of 15 SNPs showed nominally significant interactions with at least one central adiposity trait, while five and nine SNPs showed nominal interactions for WC and WHR, respectively.

71 The M1 subtype is important to learning and memory, thus antagonism via clozapine suggests one route to cognitive impairment 72 ; indeed, we observed a nominally significant association between higher cognitive ability and lower antipsychotic dose in those prescribed clozapine.

No other protein showed a nominally significant correlation for effect sizes across tissues. 3.3.2 CSF and plasma protein levels are weakly correlated Protein level correlations were calculated between CSF and plasma levels to identify proteins with similar expression levels between tissues (Figure 2 ;Table S8 ).

Considering the top 200 nominally significant genes, we did not significantly enrich KEGG/PANTHER pathways (Supplementary File 4).

Sex-stratified analyses observe nominally significant increased effect estimates in females for four CpGs.

19 Four ABCA7 variants, rs3752232, rs3764647, rs3752239, and rs4147918, showed nominally significant association in this analysis with the same direction of effect as that observed in the WES analysis.

One study has reported nominally significant genetic correlation with COPD for resting heart rate and hypertension (considered as a binary measure), with no correlation seen between COPD and stroke and other blood pressure traits [ 34 ].

We also found two nominally significant SNPs that exhibited possibly non-additive effects: ss66392234 on Chromosome 12 (in HELB) and ss66500131 on Chromosome 9 (close to the pseudogene OR7E31P) ( Table 5 ).

Four genes (PCSK9 , LPL , EDNRA and ADORA2A) were significantly associated with IHD at a 5% false discovery rate on the gene-based test, LRP1 was nominally significant and two genes (CXCL12 and CETP ) were not even nominally associated with IHD on the gene-based test.

It is critical to state that this is a secondary, exploratory finding from an underpowered study, and the nominally significant p-value should be interpreted with caution; nonetheless, the potential clinical impact of reducing extreme prematurity makes this a hypothesis worthy of serious consideration and future validation.

The results for childhood trauma were nominally significant but did not remain significant after correcting for multiple testing, possibly due to the small sample size used to conduct the pTDT and the smaller genetic correlation with autism compared to the two SSBI phenotypes.