“nominally significant”

In addition, several nominally significant positively selected sites were detected in the nonfunctional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene.

Despite none of the interdependency measures being significant after multiple testing correction, all but one nominally significant associations demonstrated positive coefficients.

Analyses of genetic differences between healthy controls assigned to different clusters identified nominally significant differences for the ADHD PGS, similarly to the MDD subtype analysis (Table S24 and Fig.

A total of 67 causal associations were identified as nominally significant in intestinal flora and eight extraintestinal manifestations, i.e., 5 in sarcoidosis, 12 in iridocyclitis, 13 in interstitial lung disease, 10 in atopic dermatitis, 9 in ankylosing spondylitis, 5 in psoriatic arthritis, 5 in PSC, and 8 in PBC.

To further complement the power simulation and examine robustness to false positives, we also quantified the frequency that the non-perturbed cell types (cell types without simulated trait-specific signals) reach a nominally significant statistical significance. seismic still maintained well-controlled false positive ratios consistent with the expected theoretical threshold (Supplementary Fig. 7 ) across multiple traits whose GWAS exhibit diverse sample sizes and genetic architectures.

Small-scale genetics studies have identified nominally significant loci associated with clozapine-induced myocarditis, 20 and genome-wide significant loci for leukopenia 21 and neutropenia or agranulocytosis. 22 , 23 Finally, a 2022 umbrella review of 10 systematic reviews of the genetic studies of clozapine response 24 concluded findings from most of the studies were inconsistent or negative.

We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case–control cohort.

The association between genetically determined T2DM and PBC (OR 0.85, 95% CI 0.73–1.00, P = 4.60 × 10 −2 ) was nominally significant but failed Bonferroni correction (Figure 3 , Table S7 ).

without anaemia ( P interaction < .100 for all measures, including a nominally significant P interaction = .022 for the decrease in LV end-systolic volume).

For the analysis of genetic data, p -values equal to or below 0.0038 (0.05 divided by 13) were considered statistically significant, while p -values between 0.0038 and 0.0500 were regarded as nominally significant.

Figures 4A–C shows examples of the top nominally significant reduced levels of these triacylglycerols based on disease severity in hypertensive patients.

A nominally significant improvement was observed for participants administered the 100-mg dose in the MDS-UPDRS Part II and for the Schwab and England Activities of Daily Living (SEADL) scale for participants administered the 50-mg dose (Table 3 ).

By employing this approach, the regression coefficient was 0.45, with a nominally significant p -value of 0.08, suggesting that SMAD3 expression increases with a greater number of cis-acting risk alleles as per an additive model ( Fig 5B ).

But after correcting for multiple comparisons, the associations between SSBP and the risk factors (WHR, TG, and FBG) turned to be nominally significant.

Furthermore, when p-values were adjusted for multiple comparisons using FDR correction, some results that were nominally significant did not remain significant.

2 - are selected for further investigation. 12 out of the total 16 steroids that show Bonferroni significance appear in two sub-networks, the first with 8 Bonferroni significant steroids, and other 2 nominally significant steroids, and other 2 unknowns: X-12844 and X-11440 (interestingly these are tentatively identified by Metabolon as tetrahydrocortisone glucuronide and hydroxypregnen-diol disulfate (or pregnenolone-diol disulfate) respectively), and the second sub-network with 4 steroids and one unknown.

p=1x10 -4 to 5x10 -8 , Figure 3b ), likely due to removal of nominally significant SNPs that are in LD with above-threshold QT/QRS loci and do not represent true association signals.

Although nominally significant, these findings require cautious interpretation because several FDR-adjusted p -values exceeded 0.5.

24 , 36 Within the Russian population, polymorphism rs11121615, an intron variant of CAZS1, was identified as a nominally significant expression, affecting genes involved in vasculature and inflammatory response. 32 Potential therapeutic targets for VVs Protective variants against VVs identified include CRIM1, 4EBP1, MMP-10, and a missense variant in GJD3. 26 , 28 , 30 Identification of pharmacologically relevant genes among identified SNPs included KRTAP5-AS1, PLEKHA5, CBWD1, and CRIM1 in the development of VVs.

We further generated a subnetwork for 169 nominally significant genes with T2D ( Fig 5B ) by their direct links.

However, in the final joint analysis of all genotyped subjects two SNVs, rs62623713 and rs35923425 ( NM_024727 :c.G1134C:p.L378F), showed nominally significant association with obesity in 1917 morbid obese and 1278 never-obese controls, with a P -value of 0.0063 (odd ratio (OR)=1.32, MAF 0.081 in obese and 0.063 in controls) or a P -value of 0.004 (OR=1.35, MAF 0.076 in obese, 0.058 in controls), respectively ( Table 3 ). rs62623713 located at 110 019 439 base pair (bp) on chromosome 1 (hg19) is a missense variant in exon 4 of the SYPL2 gene. rs35923425 located at 169 569 432 bp on chromosome 3 is also a missense variant in exon 7 of the leucine-rich repeat containing 31 ( LRRC31 ) gene.

Additionally, several other traits showed nominally significant positive correlations, including VH (rg = 0.47), sepsis (rg = 0.42), and bacterial infection (rg = 0.39).

Considering more polygenic effects, we found a nominally significant enrichment of genetic risk for cerebrovascular disease, an ADRD risk, in H 2 S‐related synthesis and persulfidation pathway gene sets.

We confirmed the association of rs1800693 in TNFRSF1A (p 4.19×10−7, OR 1.12, 7,665 cases, 8,051 controls) and rs17445836 near IRF8 (p 5.35×10−10, OR 0.84, 6,895 cases, 7,580 controls and 596 case-parent trios) The SNP rs17824933 in CD6 also showed nominally significant evidence for association (p 2.19×10−5, OR 1.11, 8,047 cases, 9,174 controls, 604 case-parent trios).

There were nominally significant positive correlations between illness duration and microstate A parameters and negative correlations between illness duration and microstate E parameters but not after correction for multiple comparisons (all p adj > .05).