“nominally significant”

While a nominally significant age-by-PrEP interaction was detected, bootstrap validation indicated limited robustness, and no overall association was found between PrEP exposure and pregnancy risk.

There was no evidence for significant main effects of age 2 after multiple comparison correction (albeit nominally significant effects were observed in the amygdala and the thalamus).

Note, however, that associations are nominally significant at the α = 0.05 level when accounting for the fact that multiple tests were conducted.

There were nominally significant increases in CSF Aβ 1-42 and Aβ 42/40 ratio in CSF and plasma respectively.

For the SGLT2 treatment analysis, most of the 34 nominally significant sncRNA associations did not remain statistically significant in the per-treatment regimen analysis, likely due to the small sample sizes within each subgroup, despite generally similar effect sizes across regimens.

We considered a p value of <0.012 (0.05/4) to be significantly different after Bonferroni correction, while p values between 0.05 and the significant threshold were considered nominally significant. 2.4.2 Sensitivity Analyses A series of sensitivity analyses were conducted to ascertain the reliability of the causal effect.

The number of Htt genotype-sensitive metabolites nominally significant at an alpha level of 0.05 varied across tissues (Chi sq.

The top five gene sets were enriched among nominally significant upregulated genes in this comparison ( Fig. 2 B), and the gene set with the lowest p- value was ‘Lek2015 loss-of-function (90)’ ( FDR = 0.00098; normalized enrichment score (NES) = 1.36; genes in gene set = 3007), which contains 3007 genes that are intolerant to loss-of-function variants.

We found nominally significant CTNNA2 associations for every phenotype.

It is clear that despite the nominally significant p-value, the two sub-populations fail to separate along these axes.

As such, we have presented the results of association for the 159 SNPs replicating to nominally significant p-values in Phase 2, as lack of functional correlation in our study does not rule out a role in ALI risk.

From the center point of the initially defined cluster, the upper and the lower boundaries were assigned to the last nominally significant variant situated at a maximum of 1 Mb in both directions.

There were nominally significant associations with reduced FA in the right parahippocampal cingulum and increased MD in the left dorsal cingulum, but these did not withstand FDR correction, as indicated in the Supplementary Tables .

In the LEARN cohort, baseline PACC performance and age explained the most variance in decline, with much less, but nominally significant, variance explained by baseline amyloid PET and P-tau217, even in this Aβ- group.

We found one nominally significant inverse association between higher cyclo (-leu-pro) and lower risk of colorectal adenoma in the Navy Colon Adenoma Study.

24 Pre‐specified secondary and sensitivity analyses such as covariate adjustment and lag‐censoring, however, revealed a nominally significant 12–15% risk reduction with cinacalcet. 24 All‐cause mortality was analysed as described previously for the primary composite endpoint.

In these neighbourhoods, we assessed disease-protein enrichment using Open Targets, aggregated nominally significant associations at the strain level, and summarized them by disease group (Fig. 4c and Supplementary Data 23 ).

The differences in absolute and relative counts of TM7s were nominally significant but in the opposite direction; that is, they were higher in the qat chewers. 4.

3 , S1, Table S3), but generally inconclusive with only borderline nominally significant effects and poor evidence of colocalization.

Similarly, after adjustment for plasma adiponectin, a nominally significant association was found with plasma insulin and HOMA-IR and ADIPOQ variant rs17300539 [ 30 ].

However, following a Bonferroni correction for multiple comparisons, no drug significantly altered locomotion in either genotype, suggesting these nominally significant locomotion changes in WT larvae reflect ‘false positives’.

In addition, nominally significant SNPs were identified in autism susceptibility candidate 2 ( AUTS2 ), inaD-like ( INADL ), chromosome 15 open reading frame 32 ( C15orf32 ), and huntingtin interacting protein ( HIP1 ) genes.

We performed validation analyses in the UK Biobank, selecting 37 traits that demonstrated either significant LDSC-based genetic correlations or nominally significant associations in the PMBB.

Another independent study utilized two-point linkage analysis in families with alcohol dependence to identify a nominally significant locus at D4S244 (Reich et al. 1998 ), which is ~5 Mb downstream of LPHN3 .

Two novel genes identified using OASIS were nominally significant, RBFOX1 and MON2 / PPM1H .