“nominally significant”

This SNP showed to have a nominally significant effect on reducing the risk for central obesity among Roma, but not in the HG population.

To assess our nominally significant findings we used three methods: (a) the gold standard Bonferroni correction to adjust p-values for multiple testing in our 12 main analyses [additive, dominant and recessive models of CLOCK SNP main effects and SNP × stress factor (CHA, RLE, or FINANC) interactions on migraineID in the total sample

IGFBP3 increases the risk of BrS and is mediated by N-palmitoyl glycine A total of 69 circulating metabolites were nominally significant, and only one metabolite (N-palmitoyl glycine, PalGly) reached the Bonferroni-corrected threshold ( p < 0.05/1190) (Supplementary Data 9 ).

However, vitamin D deficiency was nominally significant ( OR = 0.96, 95% CI [0.93, 0.98], n cases = 5768, n controls = 45,960) ( Figure 4 , Supplementary data 3 ).

Despite overall negative findings, this study unravelled nominally significant association between multifocal FMD and myosin light chain kinase ( MYLK ; previously involved in thoracic aortic aneurysms), dynein cytoplasmic heavy chain 1 gene ( DYNC2H1 ), obscurin ( OBSCN ; a sarcomeric protein) and RNF213 , previously associated with Moyamoya disease ( p = 0.01) [ 43 ].

Fourth, to evaluate whether the effect of DNA methylation on migraine is mediated through gene expression, we restricted the analysis to CpG sites that showed a significant causal association with migraine or its subtypes in the mQTL–MR analyses (used as exposures), and genes with nominally significant causal effects on migraine in the eQTL–MR analyses (used as mediators).

Table S4: Nominally significant genes associated with the FEV1/FVC ratio–FPG identified by gene-based analysis.

P value between .01 and .05 was considered nominally significant.

Nominally significant asymptotic P -values were confirmed by permuting the case–control status over 10 000 replicates to adjust for multiple testing and observing the maximum test statistic in each case.

In case of Low-fit groups compared to Med-high-fit individuals out of the 8370 “bumps”, 675 region with functional annotation was nominally significant ( Supplementary Table 1 ).

We subsequently tested the associations of ADIPOQ SNPs and cardio-metabolic traits and found nominally significant inverse associations between rs182052 and BMI and obesity status.

We found 37 miRNAs to be differentially regulated with a nominally significant P value (<0.05, 1st day vs. 9 months, Fig. 2 a).

Association results that did not survive Bonferroni correction were evaluated at the significance threshold of P < 0.05 and are considered nominally significant, pending validation in an independent population.

There are ten gut bacterial identified for T2D-dependent components of GDM with nominally significant, and there is no shared gut bacterial for T2D-dependent and T2D-independent components of GDM (Fig. 7 b-c; Additional file 1: Table S35-36).

Second, permutation tests were performed to test whether the length of sequences of consecutive nominally significant segments was above chance level.

Results We failed to detect significant differences between genotypes in depression‐like behaviors, anxiety‐like behaviors, social behaviors, sensorimotor gaiting, or learning and memory, while 1473G mice exhibited a nominally significant impairment in gait analysis, which failed to reach study‐wide significance.

Notably, we observed a number of proteins with nominally significant differences across the FTLD subtypes, suggesting that larger, more powered studies may reveal additional subtype-specific biomarkers.

The use of consistent multivariable models across outcomes further enhances comparability and the multiple-comparison analysis indicates that some nominally significant associations should be interpreted cautiously.

rs10119911, associated with cg02786370 in trans, was nominally significant in summary data from a previous GWAS of BMI [ 43 , 44 ]. rs9472010 associated with cg02786370 in trans was nominally significant in summary data from a previous GWAS of coronary artery disease [ 45 ].

In the known-race-only model, median knee pain became nominally significant, but phenotype estimates remained materially similar.

Looking for the subset of these phenotypes available in our scan of Thr95Ile, we do find a nominally significant increase in BMD but no detectable increase in MCH or erythrocyte distribution width.

As a result, the possibility of a type I error cannot be excluded, and some nominally significant associations may reflect chance findings.

Although nominally significant associations appeared in specific analyses (e.g., focal epilepsy with weight and generalized genetic epilepsy with BMI), none survived correction.

While some interactions appeared nominally significant none survived Bonferroni correction.

In the nominally significant candidate associations, the P values for heterogeneity and pleiotropy tests were all >0.05, and no obvious evidence of heterogeneity or directional horizontal pleiotropy was observed.