“nominally significant”

Before the Bonferroni correction, D3S1358 had a nominally significant p -value ( p = 0.0050), but this did not meet the corrected threshold of α = 0.0022.

This interaction was located within 400kb of an interaction identified in a large meta study (66,185 individuals [ 34 ]), which reports both an association for C-reactive protein at the same locus (P<6x10 -11 ) as well as a nominally significant interaction with sex (P<5x10 -3 ).

G2 had nominally significant overrepresentation of genes attributed to CD8 + T cells ( P = 0.005), central memory T cells ( P = 0.02), Th2 cells ( P = 0.05), and eosinophils ( P = 0.03) ( Figure 1A and Supplemental Figure 4 ).

Power to establish whether a variant is a risk factor or not is low as there were only 1774 AA cases and accordingly only R161H in SDF2L1 was even nominally significant ( p = 0.005) in AA, yet all 8 risk alleles with European MAF > 0.01 are concordant in their observed direction of effect in AA and EA (contrast the heights of the dark and lighter-blue shades for AA, or dark and lighter reds for the two EA cohorts in Fig. 1 ).

Indeed, while miR‐21a‐5p is not significant when correcting for multiple testing, it is nominally significant ( P = 0.005) and still one of the top miRs (#7), so with a larger sample size changes would likely be significant.

For rs7795011 in IMMP2L, we observed a nominally significant over-transmission of T allele in the Greek population ( p = 0.005, χ 2 = 8.0), which withstands 1,000 permutations test ( p = 0.027).

In the Results, in the “Part B cohort with infantile-onset SMA: neurodegeneration” section, the text “...compared with the ENDEAR matched sham group (30% reduction)” has been corrected to “...compared with the ENDEAR matched sham group (32% reduction)”, and “nominally significant P = 0.0050” has been corrected to “nominally significant P = 0.0075”.

HDL showed a nominally significant association (AUC = 0.601, nominal p = 0.005), but this did not remain significant after FDR-adjustment (FDR-adjusted p = 0.075).

NOS3 G894T (rs1799983) showed a nominally significant association prior to correction (OR = 0.68, 95% CI: 0.52–0.89; p = 5.069e-3), but did not survive Bonferroni adjustment (p-Bonferroni = 4.5621e-2) and should be interpreted with caution.

Similarly, scores constructed from Latino GWAS results ( P T ≤ 0.5) were of greatest predictive value among Latinos (liability R 2 = 2%; P = 3.11 × 10 −19 ) and Europeans (liability R 2 = 0.8%; P = 1.60 × 10 −9 ); with scores based on P T ≤ 0.05 and pairwise r 2 < 0.1 showing nominally significant association with case-control status among African ancestry individuals (liability R 2 = 0.2%; P = 0.00513).

The proportion of heritability of persistent ADHD attributable to common single-nucleotide polymorphisms on the liability scale (SNP- h 2 ) was 0.19 (SE = 0.024), with a nominally significant enrichment in the heritability of variants located in conserved genomic regions ( P = 5.18E−03) and in the cell-specific histone mark H3K4me1 ( P = 3.17E−02) (Fig.

The risk allele (C) of rs3851634 was associated with significantly lower levels of POLR3B ( P =7.49 × 10 −6 ) in peripheral blood analysis with a nominally significant association in skin ( P =0.0052).

Iptacopan improved the eGFR slope by +10.7 mL/min/1.73 m 2 /year compared with pretreatment decline ( P = 0.0057) and also led to a nominally significant reduction in glomerular C3 deposition (mean difference: –1.875; P = 0.0053). 66 In a study evaluating early access use of iptacopan (200 mg twice daily) in 16 patients with recurrent C3G after kidney transplantation, iptacopan was associated with potential stabilization of kidney function.

1SMR analysis identified four nominally significant associations, including genetically predicted Cer(d39:1) with higher levels of ALT (β = 0.39; 95% CI = 0.11, 0.66; P = 0.0054), and AST (β = 0.32; 95% CI = 0.03, 0.60; P = 0.028), SM(d33:1) with higher HbA1c (β = 0.39; 95% CI = 0.12, 0.65; P = 0.0042), and PC(40:8) with lower bilirubin (β = −0.28; 95% CI = −0.55, −0.01; P = 0.044) ( Fig. 4 a, Supplementary Table S11 ).

We observed a nominally significant association between the MEF2D rs200395694-A allele and presence of anti-Sm antibodies ( p = 0.0058) and anti-RNP antibodies ( p = 0.017) with Fisher’s exact test.

We found nominally significant subcortical volumetric differences in the bilateral thalami (left Cohen d = −0.29, p = 5.83 × 10 −3 ; right d = −0.24, p = 0.025), bilateral hippocampi (left d = −0.36, p = 8.85 × 10 −4 ; right d = −0.41, p = 1.15 × 10 −4 ), bilateral amygdalae (left d = −0.31, p = 4.02 × 10 −3 ; right d = −0.17, p = 0.014) and right nucleus accumbens ( d = −0.21, p = 0.048) between the patients with schizophrenia and controls ( Figure 2A and Figure 3 ).

ii) Nominally significant differences were observed in the levels of IL-1RA (p = 0.0059), YKL40 (p = 0.0069), CatS (p = 0.013), sTNFR1 (p = 0.031), and BDNF (p = 0.020), where these factors exhibited higher plasma levels in Cannabis user SCZ patients than in non-users. iii) These differences in systemic levels were not reflected by altered mRNA expression of genes encoding sgp130, IL-1RA, YKL40, CatS, sTNFR1, and BDNF in whole blood.

In MS patients, none of these correlations survived the FDR correction, but butyrate and valerate concentrations showed nominally significant positive correlations with TNF (rho=0.374, p=0.006 and rho=0.370, p=0.006, respectively).

( 2012 ), we find 450 in the genome in autism; compared to this, four hits in our gene set reflect a nominally significant enrichment (3.6 fold; p = 0.006, Poisson test).

The lead SNP for the interaction between glaucoma status and the PDE7A / MTFR1 genomic region for RAVLT delayed recall, rs17395878, was also nominally significant ( P = 0.006).

We observed several complex interactions, notably suggesting an increased risk of severe neutropenia in patients carrying a homozygous variant CYP3A5 rs776746 genotype (nominally significant OR 5.58, p = 0.006) and a potential pleiotropic protective effect from NFATC2 rs6021191 (OR 0.09, p = 0.001).

Supplementary Table SVII presents the weighted median analysis, which indicates a nominally significant protective influence for both VPA (OR = 0.991; 95% CI: 0.984–0.997; p = 0.006) and SSOE (OR = 0.986; 95% CI: 0.978–0.995; p = 0.002).

Although a nominally significant difference was observed between the ONDD and ASD groups ( p = 0.006), this did not survive correction for multiple comparisons.

Nominally significant interactions ( P = 0.006–0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci ( GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci ( LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjusted WHR or BMI outcomes.

A single nominally significant association was observed for EDSS: horizontal smooth pursuit velocity error (ρ = 0.41, p = 0.006, q = 0.35, adjusted for age and baseline EDSS), which did not survive FDR correction.