“nominally significant”

Conclusion In this large phylogenetic and GWAS analysis, we found a substantial and significant heritability of SRNCs in PWH and could identify one viral variant that was significantly associated with SRNCs and several more candidates, which were nominally significant though not after adjusting for multiple testing but were previously linked to HIV-associated dementia or CSF-derived sequences.

We observed that of the 167 HEI-associated OTUs, 71 were nominally significant in difference between “healthy diet” to “less healthy diet” pairs, and 17 were FDR-adjusted significant to q < 0.05 (Fig. 2 ).

12% in metformin users, with a nominally significant P interaction of 0.03 [ 21 ].

A list of the top 10 associated genes, that is, those with a nominally significant gene-based P -value in the analysis of the full set of SNPs, is provided in Table 2 .

Targeted analysis of 84 CpGs in the BDNF promoter revealed 10 nominally significant CpGs that differentiated responders from non-responders.

P-values of <0.05 were regarded as nominally significant.

For five of the remaining seven postmortem case-control DE signatures, nominally significant evidence for the characteristic pattern was observed.

Sex interactions 14 of the top 20 ever-critical-care proteins showed nominally significant interaction with sex, generally with stronger associations in women.

The average CADD PHRED score for the 2,528 nominally significant variants was 22.05 (6.25 SD ).

However, compared to previous results, the paracentral gyrus ( β = −0.035, p uncorrected = 0.047) and insula ( β = −0.034, p uncorrected = 0.048) became only nominally significant before FDR correction while precentral cortex ( β = −0.024, p uncorrected = 0.167) was no longer significant.

Nevertheless, with p -values < 0.05, these results hold nominally significant ( Supplementary Table S1 ).

These GTP DNAm correlations were also nominally significant in NSG blood samples.

Finally, because several P values were close to the conventional significance threshold and many tests were conducted, it is likely that some nominally significant associations would not remain significant after multiple-testing adjustment and should be interpreted with caution. 5.

In addition to diabetes, analyses in UK Biobank (UKB) of a functional variant of PCSK9 (rs11591147) suggested possible excess risks of several non-vascular disease outcomes, including asthma and respiratory tract infections 22 , 25 , although these associations were only nominally significant and require replication.

Only two CpG sites, cg03793277 ( APOC1 ) and cg05249393 ( LDLR ), were nominally significant in our study.

In GBM, we see that differential expression status of ESR2 is also nominally significant in stratifying patient survival.

However, when the VEGAS2 results were compared with previously published gene expression analysis, we found SLC25A13 was nominally significant for 3 of the 9 OCT traits tested, ENPP2 was found to be nominally significant in 2 out of 9 OCT traits tested and CALCRL was also found to be significant in 2 out of 9 OCT traits tested.

Since power calculations were based on fatty acids, also nominally significant ( p unadjusted < 0.05) results were considered for lipid mediators.

Users are also permitted to access all nominally significant results (< 0.05, uncorrected) by setting the multiple testing correction parameter to ‘nom’.

We further tested in 384 females (age range 39–83 years) from TUK the association of whole blood gene expression of the genes encoding all 13 proteins and found three of them (CST3, FSTL3, and HAVCR2) to be nominally significant ( Supplementary Table S2 ).

Other SNP in MAP3K5 (rs9402839) was nominally significant for atopy in pooling sample and border significant in the replication step.

Models confirmed no differences in the effect sizes of the intervention by age group and found no difference in the intervention effect between urban and indigenous communities for children 2–4 and 5–7 years old (Tables 2 and 3 ); however, the anemia model for 5–7 year olds indicated a nominally significant intervention difference prior to inclusion of the random community effect (0.857 lower log odds of anemia in indigenous vs. urban communities following intervention, p=0.0843, model not shown).

Using the 1.3K assay overall accuracy plateaued at around 100 of the most significant protein-pQTLs pairs but including all nominally significant protein-pQTLs pairs led to slightly lower accuracy, suggesting that these lower significance pairs were introducing more noise than signal and accuracy and having additional protein information is not informative for matching to genomes.

107 Tezepelumab, a first-in-class human IgG 2/λ mAb that binds to TSLP and inhibits its interaction with the TSLP receptor complex, has recently been documented to result in a nominally significant reduction of 37% in the rate of moderate or severe AECOPDs in comparison to placebo. 44 In patients with a blood eosinophil count of 300 cells/μL or greater, tezepelumab resulted in a statistically significant reduction of 46% in the incidence of moderate or severe AECOPDs.

The main outcome of the study was the presence of an association between self‐reported peer victimization and genetic risk for depression, attention‐deficit/hyperactivity disorder (ADHD), risk‐taking behaviors, BMI, and intelligence, with a nominally significant effect of polygenic risk for SCZ.