“nominally significant”

Of note, WC not adjusted for BMI was not associated with any of the JAZF1 SNPs, while BMI showed nominally significant associations with all eight SNPs, with the most significant association with the variant at position 7:28178625 which was also associated with WCadjBMI.

Results Candidate SNPs, genes and pathways from the previous literature None of the SNPs previously reported in the literature (see Introduction) had even a nominally significant effect on left-handedness in the UK Biobank dataset (Table 1 ), i.e. no P values were less than 0.05.

This suggests that some of the 18 candidate variants are true risk variants for ID (see Supplementary Data 6 for all 57 nominally significant associations).

P -values ≤ 0.01 were considered nominally significant.

Results that did not meet the adjusted significance thresholds were interpreted as nominally significant.

For each transcript, we counted the number of experiments where the significance for differential expression was ≤0.05, and then generated the binomial probability, referred to as the consensome p value (CPV), of observing that many or more nominally significant experiments out of the number of experiments in which the transcript was assayed, given a true probability of 0.05. p values were adjusted using the p.adj function in R to generate q values (CQV).

Both comparisons were nominally significant but failed to pass multiple testing correction, but the Diff comparison was statistically significant.

However, the majority of the observed DMCs in SLE were nominally significant also in the group of patients not treated with glucocorticoids.

For genetic data p -values up to 0.0036 (0.05/14) were considered statistically significant, while p values between 0.0036 and 0.0500 were considered nominally significant.

We note that some nominally significant associations had ORs very close to 1 (e.g.

Cross-referencing of sex-biased eQTLs reported in GTEx 60 found that MSRA had nominally significant sex-biased eQTLs in tibial nerve tissue and Brain cortex, but not in whole blood.

Specifically, while Cipa+mig did not achieve statistical superiority over ALG for improving 6MWT in PROPEL, it did in the ML-NMR [ 24 , 46 ] and, while the COMET study showed a nominally significant benefit of AVA versus ALG based on 6MWT, the direction of results from the ML-NMR suggests otherwise.

boundary ≈ 4.72), indicating that, despite a nominally significant conventional meta‐analytic result, the TSA remained inconclusive because the accrued information size was limited and the available evidence may still be vulnerable to random error.

Genome-wide association searches with SNPs We achieved for lnBQ , ERP-M , and ERP-P 745, 807, and 734 nominally significant results out of 15264–15268 SNPs tested for association.

However, a comparative analysis of the nominally significant SNPs with our previous GWA study for BFT obtained using the same animals analyzed in this study [ 12 ] indirectly supported, to some extent, the identified association results.

We found two additional, nominally significant SNPs relatively proximal to others reported associated with CRP level, such as rs7635320 within 1.5 Mb of reported rs1514895 on chr 3, and rs7143416 within 2 Mb of reported rs112635299 on chr 14.

We have recently demonstrated nominally significant associations between SAP97 gene and schizophrenia among Japanese males.

Because only published and nominally significant values are considered, this makes effect estimates arguably insensitive to non-retrievable unpublished (and therefore likely non-significant) results and makes it possible to assess more insidious forms of dissemination bias such as p -hacking (e.g., repeated calculation of significance statistics in primary studies by means of different methods or inclusion of different a posteriori-selected covariates, until nominal significance is achieved).

The FDR was calculated with the significance analysis of microarrays (SAM) tool as the median number of false-positive genes from permutation testing divided by the number of nominally significant genes defined from the unperturbed data 11 .

The analysis of associations between MRI findings and patient characteristics revealed several nominally significant relationships.

We observed that there is not an overall destabilisation of methylation patterns in ICRs, but specific DMRs, such as the H19 DMR, can show a weak but nominally significant association with the method of conception.

A p -value of <0.05 was considered nominally significant, and the significance for multiple comparisons was further adjusted with a false discovery rate (FDR) (significance: p <0.05 and FDR<0.1), suggested by Benjamini and Hochberg [34] .

In Model 3, the interaction of trait mindfulness with the intervention effect was nominally significant only for intrinsic motivation.

Alternatively, the associative screen is first conducted for the methylome and other molecular species separately and then the nominally significant marks are mapped to a common identifier, often genes or pathways.

While the finding that links nc886 methylation to the season of conception remains nominally significant, it is not replicated in a dataset with a similar study setting ( GSE99863 ) ( Figure 4a ).