“nominally significant”

Only two of the five novel variants were available for testing in the CREAM cohort; rs1353386 was convincingly replicated while rs55754534 was nominally significant.

Using the parental transmitted and nontransmitted alleles in individual-level parent-offspring data from Iceland and Norway (deCODE, MoBa and HUNT; n = 46,105 parent-offsprings; Supplementary Table 11 ), we observed a nominally significant association between the maternal nontransmitted alleles polygenic scores for CBAT and testosterone and gestational duration.

For all test procedures, p values < 0.05 have been considered nominally significant.

Although these differences were not even nominally significant in SLI, they may suggest that if HLA alleles play a role in both SLI and autism, the mechanism itself may be different.

This effect was nominally significant but did not remain after Bonferroni correction.

Another gene that we found to be downregulated in the mouse GE is Eomes , which we also found to be specifically expressed in the human VZ and SVZ early in development (however note that expression of EOMES 8–9 pcw compared to all later stages was only nominally significant and did not survive correction for multiple testing) (Figures 3 , 4 ).

And none of the 11 subgroups showed a nominally significant interaction between treatment and subgroup.

To explore the associations between the SNPs and phenotypes related to smoking and cancer in the initial 300 subjects, the χ 2 test was performed overall, and SNPs that showed P < 0.05 in the analysis were considered nominally significant and selected for further analysis.

A nominally significant interaction was also observed between the SNP and glycated hemoglobin (HbA1c) [34] .

Analyses of the combined data set showed an association of the 647C variant and alcohol dependence with withdrawal seizures at the nominally significant level.

No correction was performed for multiple analyses and p values of less than 5% were considered to be nominally significant and exploratory in nature. 95% CI were calculated where appropriate.

From our variant-based association study, we first discovered an Asian-specific rare heterozygous missense variant in OR51G1 showing a nominally significant association with the same direction of effect in the both the discovery and replication sets.

Correction for multiple testing was performed by permutation test (n = 100,000), for the dominant model that showed nominally significant results, using PLINK.

Nominally significant GO terms were subsequently submitted to the REViGO tool ( http://revigo.irb.hr/ ) [ 32 ] to identify and remove redundancy using Resnik’s measure while allowing a terms similarity of 0.7.

p values were calculated using Student t test and were considered nominally significant at <0.05.

Although these transcripts were only nominally significant in the microarray analysis, their regulation was confirmed in vivo by qPCR using aortas from Ccn2 Δ/Δ and Ccn2 fl/fl mice ( Figure 2 I ).

Influence of Moderating Factors Moderation by sex: In sex interaction models, 19 and 18 nominally significant miRNAs were identified for total WML volume and number of WMLs, respectively ( Table S5 , Figure S14 ).

When controlling for PTE, nominally significant moderation effects for PAE on the Expressive Communication-graph theory metric associations remained similar to the models without PTE ( Table 4 ).

Although no homologous group was significant at False Discovery Rate (FDR)<0.05 (which appears to be too strict for comparisons across multiple species), by the more relaxed criterion of having a binomial p-value<0.05, four homologous groups were nominally significant: CAB39 , the genes encoding 14-3-3 proteins, sirtuins, and AHCY encoding S-adenosylhomocysteinase.

P < 0.05 was considered nominally significant.

Studies in both postmortem and living human brain tissue have found limited correlations between methylation patterns in the brain and peripheral tissue of patients, with the highest interindividual correlation between nominally significant CpG sites in brain and blood at roughly 20%. 71 , 72 , 73 However, some analyses have shown that the correlation between methylation across brain and blood is stronger at certain CpG sites, and analyses of DNA methylation in blood could focus on these sites. 72 Studies of methylation in brain tissue from AUD cases rely on postmortem cohorts, which usually have a limited number of subjects.

After Benjamini–Hochberg FDR adjustment, ABCA1 and LCAT remained statistically significant, whereas the other nominally significant genes did not retain significance.

These yielded directionally consistent IVW estimates, which were at least nominally significant in the unfiltered analyses for all the main, primary associations (Supplementary Table 5).

The gene based statistics conducted using VEGAS indicate that one gene was nominally significant for crystallised ability and three for fluid ability.

Statistical analyses were performed using SPSS Statistics (version 27.0; IBM Corp., Armonk, NY, USA); a two-sided p -value < 0.05 was considered nominally significant for this exploratory analysis. 3.