“nominally significant”

Conclusions: We identified a nominally significant association between prenatal opioid exposure and DNAm at one CpG site.

Although ABCA7 was not prioritized after accounting for multiple testing across tissues, over 60% of ABCA7 –tissue combinations displayed nominally significant P -values, indicating that variants related to this gene may have caused this signal.

For region-level analyses, given the 408 MR estimates, a Bonferroni-corrected P-value was set as 0.05/408 (1.22×10 −4 ), and meanwhile P < 0.05 was regarded as nominally significant. 5.

This analysis only yielded a nominally significant association in the VTA/SN.

Another recent study analysed the association between SNPs from 46 previously reported adult height loci in children and found nominally significant associations for 15 loci ( 16 ), but that study analysed together all children between the ages of 0 and 18 years (preventing identification of age-specific effects) and does not have repeat measures on the same children.

The leading miRs for the negative health outcome cluster were miR-27b-3p, which had the highest number of significant associations and miR-148a-3p, which had very similar profile although some of the associations were only nominally significant.

However, this provides little additional information beyond the study result’s associated p -value; for example, a finding that is nominally significant at the 5% level will have at least 50% power, and 80% power is guaranteed if the p -value is below 0.005 [ 15 ].

Of these, 122 were autosomal SNPs, of which we selected 35 common SNPs (minor allele frequency >5%) that had at least a nominally significant and directionally consistent association with 25(OH)D in an earlier independent GWAS by the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) Consortium, which did not include the UK Biobank ( 32 ) ( Supplemental Table 3 ).

These are nominally significant associations, none of which survived adjustment for multiple comparisons.

In our analysis of primary traits of interest among the other available metabolic and anthropometric phenotypes in a candidate PheWAS (phenome-wide association study) we found a few nominally significant associations (Table 3 ).

In contrast, a nonsignificant P value was obtained when excluding the eight associated variants from the analysis, which would be consistent with the association being driven entirely by the nominally significant variants.

For each immune cell type, nominally significant genes were partitioned into up-regulated and down-regulated sets and submitted separately to identify perturbagens whose transcriptional signatures were either concordant (“Up”) or inversely aligned (“Down”) with the observed expression patterns.

However, we observed a nominally significant role for the IL6R rs2228145 A>C variant and treatment response in our full cohort.

Notably, the N 10 ‐formyltetrahydrofolate biosynthesis pathway survived multiple testing correction, while Vitamin B6 pathways were nominally significant.

A study in patients with schizophrenia reported a nominally significant decrease in basal PBMC TA in cases compared to controls. 71) Two genetic studies deserve mentioning; in a study in Han Chinese subjects researchers investigated NVL gene variants in cases with MDD and schizophrenia and compared these to non-psychiatric controls.

For nominally significant methylation sites, we further conducted multivariable logistic regression analyses to assess their associations with bleeding risk in patients with CHD.

Of those, 30 proteins were nominally significant in model 1, with 97% being directionally consistent with the observations in AGES (Fig. 2f ).

CRP The genetically instrumented CRP showed only nominally significant associations, with ORs ranging from 1.31 to 1.60 for different COVID-19 datasets ( Figure 4 , Table S3 ).

The correlation coefficients were all positive (Spearman correlation coefficient rho = [0.12–0.68]) and nominally significant for TEP62 (Supplementary Fig. 7 ).

The significant associations with WBC-related codes identified in the AoU PheWAS remained highly significant in this analysis, and a few nominally significant associations also emerged ( supplemental Figure 4 ).

Although nominally significant in unadjusted analyses, the observed between-group difference of approximately 5–7 ng/mL was modest, and median values in both groups remained close to commonly accepted thresholds for vitamin D sufficiency.

In males, the association at PRDM9 was only nominally significant ( S13 Fig ).

For new or worsening nephropathy there was a nominally significant quantitative interaction with a p-value of 0.0013 due to an inconsistent pattern of treatment effect (U-shaped pattern with lowest HRs of 0.45 and 0.42 in patients without MetS and those fulfilling 4–5 criteria compared to HRs of 0.81 and 0.71 in those fulfilling 2 or 3 criteria, respectively).

Consistently, the HRs from the adjusted model for the comparison of ET versus ribociclib (HR = 1.288; 95%‐CI: [1.006; 1.649]) or CT versus ribociclib (HR = 1.776; 95%‐CI: [1.377; 2.290]) were in favor of ribociclib, and the related 95%‐CIs indicated nominally significant differences.

Among the nominally significant proteins, the chemokines MCP-1, CXCL9, CXCL10, and CXCL11 tended to increase, suggesting normalization by day 7 ( Figure S3a ).