“nominally significant”

Interestingly, a model including an interaction term between cannabis use and FEP status identified two sites that were significantly associated with current cannabis use with a nominally significant interaction suggesting that FEP status might moderate how cannabis use affects DNA methylation.

The International Schizophrenia Consortium also found that a collection of thousands of nominally significant SNPs collectively capture over one-third of the heritability for schizophrenia, a disease that has proven particularly refractory to the discovery of large effect alleles [ 9 ].

The primary endpoint of endoscopic response at 4-weeks was not reached, but secondary endpoints were nominally significant, favoring antifungal therapy (reduction in Robart’s histological score [74% vs. 33%] and fCal [84% vs. 37%]).

Main effects of variation in P2RX7 on current anxiety symptoms Our linear regression models on current anxiety symptoms identified no SNPs with a nominally significant main effect, therefore clumps could not be formed.

We have detected nominally significant effects at RA susceptibility variants mapping to the AFF3 and CD226 genes.

When subjected to multiple testing correction via the false discovery rate approach, none of these associations achieved statistical significance (all FDR > 0.05), indicating that these findings represent preliminary, hypothesis-generating signals. Robustness Assessment of Forward Analysis Sensitivity testing confirmed the stability of these nominally significant findings.

Pathway analysis was performed in XGR 20 with the GOBP dataset,“elim” algorithm and hypergeometric test across all nominally significant (FDR < 0.5) genes.

Linkage disequilibrium (LD) patterns of the genes with nominally significant variants were reconstructed using Haploview version 4.2 ( Barrett et al., 2005 ).

Conversely, several regions with LEA associations revealed GWAS SNPs that were nominally significant.

For BMI the TWAS association was nominally significant in 23 out of 34 cases, and the sign of the correlation was concordant with the one found by SMR for all of them.

Rather we have emphasized those nominally significant associations with CCR2-CCR5 variants that have previously been implicated in HIV/AIDS and de-emphasized those whose involvement was less predictable from earlier studies.

Nevertheless, nine of them (rs541503 ( PHGDH ), rs715 ( CPS1 ), rs272893 ( SLC22A4 / OCTH1 ), rs9393903 ( ELOVL2 ), rs3204953 ( REV3L ), rs603424 ( SCD ), rs174550 ( FADS1 ), rs499974 ( MOGAT2 ), rs7157785 ( SGPP1 )) showed nominally significant association with diabetes in published data from bigger GWAS consortia for type 2 diabetes (up to 110.452 individuals) or exome array analyses (up to 75.670 individuals) of which two (rs174550 ( FADS1 ) and rs3204953 ( REV3L )) were significant after correction for multiple testing by FDR (Table 3 ).

The odds ratio (OR) of the Ala allele in DR was calculated with the Mantel–Haenszel test in FEM or the DerSimonian & Liard test in REM; p<0.05 is considered nominally significant.

This discussion focuses on the nominally significant findings.

In addition, recent studies have found that sets of SNPs of nominal significance might be used to identify genomic regions that are over-represented across independent GWAS 97 , 98 —here as well, cell-adhesion genes, such as cadherins, are prominent, although only nominally significant in the individual studies.

However, as the outcome disparities between ethnicities could not be fully explained, although only nominally significant, and the ethnicities within the European pediatric population are underrepresented in previous studies regarding MAFLD, more follow up studies are needed focused on the ethnic disparities in risk for MAFLD within these populations.

Post hoc analyses showed that the number of one-night stands showed a nominally significant association ( P rec =0.048, Wald(1)=3.9, R 2 =0.011), whereas there was no significant relationship between the VN1R1 polymorphism and item (ii) or (iii) ( P -values >0.5).

None of the transcripts associated with smoking status in our study were identified in a previous whole-blood transcriptome meta-analysis, including more than 10,000 individuals, of current versus never smokers [ 35 ], and none of the top 10 hits from that study were nominally significant in our study.

Although SNPs at the APP locus were nominally significant (min p value within 10 kb = 9.56×10 −6 ), none made the genome-wide significance cutoff.

A total of 16 proteins showed a nominally significant differential abundance in pediatric patients with AIH compared to controls.

Using an independent cohort, the study found a nominally significant association for antidepressant response and PRS for antidepressant remission calculated from their own GWAS summary statistics.

This may explain only nominally significant validation results in the mixed-cell subtype.

Nominally significant p -value threshold was set at 0.05.

With a naive model (GLM GWAS), nominally significant associations were found on all chromosomes for panicle length, plant height, and flowering time, and a large number of these colocalized with a priori candidate genes (Fig.

We also examined two dietary exposures across three dentition strata and multiple supplementary analyses without formal adjustment for multiplicity, so the nominally significant observed-outcome vegetable estimate should be regarded as exploratory.