“nominally significant”

The only nominally significant finding among the quality-of-life outcomes was observed for the Financial Difficulties subscale, where the EXSUPP group reported lower scores compared with EXPLA (−13.52; p = 0.04; 95% CI −26.24 to −0.80; d = −0.91).

p -Values < 0.05 were considered as being nominally significant; as the study was largely exploratory in nature, no corrections were made to take into account multiple testing issues.

This indicates that many of the nominally significant genes truly differentiate the normal and diseased states, and that many of our findings will become significant in larger sample sizes.

Nevertheless, it reached nominally significant results and gave preliminary support for an association between the methylation of ESR1, GABBR1 , and MOG and the severity of the OCD and treatment outcome.

In contrast, fam57ba − / − mutants needed 5 mM PTZ to show a nominally significant increase in velocity compared to wild-type.

SNPs with nominally significant effects were retained for further analyses (α = 0.05). 2.9.

3 Semaglutide treatment significantly reduced the risk of MACE‐3 (non‐fatal myocardial infarction, non‐fatal stroke, cardiovascular death) by 20% compared with placebo (hazard ratio: 0.80, 95% confidence interval [CI]: 0.72 to 0.90; p < 0.001), with nominally significant reductions in heart failure outcomes and all‐cause mortality. 3 The results of this trial have increased interest in obesity management medications in the cardiovascular and other scientific communities.

The tests revealed two nominally significant differences between the edges of right-wing participants at T1 and T2.

Dysthymia was significantly associated with a decrease in 3,4-Dihydroxyphenylacetic acid (DOPAC) synthesis after adjustment for SSRI use ( Figure 5 , Table S17; β=-0.6, SE = 0.2, P adj = 0.002, FDR adj = 0.03), while a nominally significant association remained after adjustment for any PTD use (Table S18; β=-0.6, SE = 0.2, P adj = 0.002, FDR adj = 0.06).

Since the Bonferroni level of significance was not achieved for any of the identified associations, pathway enrichment analysis was performed based on identifying pathways reported by nominally significant metabolites more frequently than can be attributed to random chance.

RPS23P3 /rs6851574 was also nominally significant in male participants but not in female participants for decline of global function ( P male = 1.87E‐05, β male = 0.149; P female = 7.93E‐01, β female = −0.009), visuospatial function ( P male = 1.11E‐02, β male = 0.094; P female = 6.00E‐01, β female = −0.018), and language ( P male = 2.50E‐02, β male = 0.080; P female = 9.52E‐01, β female = −0.002; see also Table S1 ).

In a larger population-based genetic association study of empathy, we found a nominally significant association of CNR1 genetic variation with the Empathy Quotient [ 55 , 57 ].

2016 ) but nominally significant differences between maternal and fetus side have been reported (Bakulski et al. 2021 ).

Colocalization of SLC41A1 Expression and Neuropsychiatric Disorders Colocalization analysis was performed for ten outcomes that satisfied the MR inclusion criteria, comprising four Bonferroni-significant and six nominally significant disorders.

A p-value < 0.05 was considered nominally significant. eGFR slope eGFR slope vs. time was analyzed in both sets of propensity-matched cohorts using a mixed-model repeated measures (MMRM) analysis to estimate the overall treatment effect on eGFR slope.

A total of 58 SNVs in 22 genes and 37 SNVs in 16 genes showed nominally significant associations with the Alda A continuous score and the acute-VPAR group, respectively.

It was once reported that C allele of rs9651118 was associated with reduced lung cancer risk in never smokers, and a nominally significant association with schizophrenia in the form of haplotypes (rs1801133, rs17421511, rs17037396, and rs9651118) in Japanese population [ 27 , 28 ].

We identified 15 phenotypes without a nominally significant PRS association including adverse drug events, as well as recurrent seizures, extrapyramidal disease and abnormal movement disorder, tachycardia, and torsion dystonia, which have all been previously linked to antipsychotic treatment ( 66 , 67 , 68 , 70 , 71 , 72 ), thus validating our hypothesis.

We thus tested all samples for concordantly regulated transcripts with at least a 1.25-fold change, a q value <10%, and a nominally significant P value in both tissues ( Supplementary Table 12 ).

Employing FDR control, all of our nominally significant parameters remained significant with the highest p -value below 0.05 being p uncorr = 0.017 and p FDR = 0.025.

Similarly, TCF7L2 rs7903146 showed a nominally significant association under the dominant model in adjusted analysis; however, this finding also did not persist after correction for multiple testing.

Methylation in smoke-exposed was compared to unexposed fetal lung samples and were considered nominally significant at a p-value cut off of 0.05.

In logistic regression analysis the association was only nominally significant (Supplementary Data 10 ).

Among the genes tested in at least two tissues, 75% (14,304 out of 19,020) show nominally significant heterogeneity.

There were also nominally significant trends for these same stroke subtypes with the Lipodystrophy cluster.