“nominally significant”

In the multivariable analysis ( Table 2 ), adjusting for age, sex, total cholesterol, log-triglycerides, use of lipid-lowering drugs (statins, fibrate, and/or fish oil), and the first three multidimensional scaling coordinates (population genetic substructure), seven SNPs showed nominally significant associations with cIMT max , but only three remained significant after correction for multiple testing (rs34760410, rs12920974, and rs12708968).

p -values up to 0.0083 (0.05/6) were considered statistically significant, while p -values between 0.0083 and 0.0500 were considered nominally significant.

Furthermore, other pain sites, including headaches, were also nominally significant in our analysis (Table S2, available as supplemental digital content at http://links.lww.com/PAIN/B790 ), reinforcing the effect of the gene on overall pain states.

This nominally significant odds ratio was subject to considerable bias across the studies (small study effect bias and replication diversity).

Other differences were nominally significant but did not pass the adjusted thresholds.

In this pilot cohort, 13 proteins showed nominally significant correlations with NIHSS scores, suggesting they may reflect biological processes linked to neurological status after IPC.

Association of each independent SNP with AO revealed nominally significant p-values (P [rs7480166] = 8.42 × 10 −6 , P [rs62171220] = 6.33 × 10 −3 , P [rs2067390] = 4.51 × 10 −5 , P [rs144891322] = 1.14 × 10 −5 , P [rs11529293] = 1.62 × 10 −5 , P [rs585809] = 2.91 × 10 −5 , P [rs72660056] = 1.66 × 10 −3 , P [rs11857349] = 8.21 × 10 −6 , P [rs8141510] = 1.33 × 10 −3 ).

Topological analysis of PPI networks and experimental validation of hub genes To identify key regulatory nodes characterized by high connectivity and substantial magnitude of dysregulation, we constructed a PPI network based on the network discovery set (367 nominally significant DEGs).

In ever-smokers, results were directionally consistent, with five metabolites remaining nominally significant.

3 It is worth mentioning that nominally significant variants in the surrounding region of rs35705950 are located near the MUC5AC gene.

used Mendelian randomization (MiBioGen taxa as exposures; OCD as outcome) and reported several nominally significant associations between gut taxa and OCD such as lower Proteobacteria associated with lower OCD odds [ 76 ].

Using region-based and gene-based association analyses, we identified several loci showing nominally significant association.

Inclusion of the interaction term resulted in a nominally significant PC2 vs. group interaction ( P FDR = 0.3883, P raw = 0.0485) showing that the effect of PC2 was stronger in the meat group (0.346) compared with dairy (0.050).

Overall, our results highlighted the possibility of nominally significant associations of the OXTR gene with the severity and improvement in schizophrenia symptoms.

A P < .05 was considered nominally significant ( Supplementary Methods ).

With the exception of DNAmB2M, seven components showed nominally significant differences in various pairwise comparisons.

The largest observed (and nominally significant, but exploratory) effect on the ADAS-Cog was seen at the 0.15 mg/kg dose, but not corroborated by data from the DAD at that dose.

The PLSR shows no significant associations in HAR, negative associations between SD affiliation and BD (non-significant) and BMI (nominally significant), but positive association between Ohno and BD (significant).

The other nominally significant variants are shown in Supplementary Table S1 .

Gross-Motor Milestones The association analyses between the child 6mo (six months) metabolic profiles and gross-motor milestone PC1, identified 62 metabolites as nominally significant among the 984 metabolites investigated, with 10 out of 62 being positively associated, including tyramine-O-sulfate as the strongest finding (β-estimate 0.30, CI 0.14–0.46, SE 0.08).

82/106 associated models were significantly correlated with expression/splicing measured in at least one independent cohort (after Bonferroni correction for 388 model-by-cohort pairs tested, with 92/106 nominally significant after Bonferroni correction for 4 cohorts tested).

Notably, 5 of the 17 risk alleles had nominally significant association with type 2 diabetes, the strongest effect being observed for the rs7903146 SNP at the TCF7L2 locus.

Achievement of 50% MMD reduction over months 4 to 6 showed a nominally significant improvement in the erenumab, 140 mg, group (109 [56.2%]) and 70 mg group (81 [41.8%]) relative to placebo (51 [26.3%]) (eTable 12 in Supplement 1 ).

One SNP from GWAS was significantly associated with keratoconus, i.e., RXRA-COL5A1 rs1536482 (P = 1.5 × 10 −5 , I 2 = 0), while FOXO1 rs2721051 (P = 9.4 × 10 −3 , I 2 = 0), BANP-ZNF469 rs9938149 (P = 0.017, I 2 = 27%), COL4A4 (rs2228557, P = 0.020, I 2 = 70%) and COL4A3 (c.2685 A > C, P = 0.032, I 2 = 0) were nominally significant (Table 3 ).

19 reported nominally significant improvement in many EORTC-QLQC30 symptom domains with pembrolizumab, and nominally significant worsening with docetaxel.