“nominally significant”

The MR estimate for owning one’s own accommodation was nominally significant and negative (−1.02; 95% CI: −1.85 to −0.18; P = 0.004) but should be considered in the context of the number of associations tested.

Impact of pridopidine on global clinical progression (cUHDRS) In the mITT population off ADMs, pridopidine showed nominally significant benefits in maintaining cUHDRS scores compared with placebo, with the largest differences (Δ) at week 26 (Δ = 0.46, P = 0.004; placebo n = 112, pridopidine n = 95), week 39 (Δ = 0.45, P = 0.014; placebo n = 107, pridopidine n = 90) and week 52 (Δ = 0.41, P = 0.035; placebo n = 104, pridopidine n = 91) (Fig. 3a ).

LBC1921 Childhood cognitive ability in LBC1921 There was a nominally significant association between three SNPs and age 11 Moray House Test (MHT) score: CTSZ , rs9760 (F = 5.625, p = 0.004, η 2 = 0.025); GSTZ1 , rs3177429 (F = 4.820, p = 0.009, η 2 = 0.022); NDUFS4 rs31304 (F = 9.757, p = 0.002, η 2 = 0.022).

Among which tryptophan betaine was the most significant causal metabolite in both AF GWAS data (from Nielsen et al.) (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.76–0.90, P = 9.37 × 10 −6 ) and AF GWAS data (from Roselli et al.) (OR = 0.82, 95% CI = 0.76–0.88, P = 2.00 × 10 −7 ), while uridine was nominally significant metabolites in both AF GWAS data (from Nielsen et al.) (OR = 0.58, 95% CI = 0.40–0.84, P = 0.004) and AF GWAS data (from Roselli et al.) (OR = 0.56, 95% CI = 0.35–0.88, P = 0.01).

In contrast, among whole‐brain studies the only region that showed a nominally significant effect of diagnosis was the nucleus accumbens ( P = 0.004).

Results: Dermoscopy showed a nominally significant shift toward smaller vessel diameter categories after therapy (ATS = 8.183, df = 1, p = 0.004).

In contrast, genes near TET2 -associated sites showed nominally significant depletion for HSC marker genes (OR = 0.46; P = 0.004), though were enriched for marker genesets for naïve T cells, monocytes, and neutrophils (1 × 10 −14 < P < 0.0008; Supplementary Fig. 9 ).

The FDR was 0.43, but it was accompanied by a nominally significant P-value (P = 0.004).

Moreover, when comparing a mouse model of extremes in trait anxiety with normal mice, nominally significant differences were observed in Tmem132d mRNA expression in the cingulate cortex using a microarray experiment ( p = 0.004).

Musk deer relative abundance also showed strongly significant differences across protected areas (F 2,27 = 43.86, P<0.001) and showed nominally significant differences across areas not under formal protection (F 2,22 = 7.22, P = 0.004).

This SNP was also nominally significant in the subgroup analyses of HTG ( P = 0.004, OR = 1.26, 95% CI: 1.08–1.47), but not NTG ( P = 0.13, OR = 1.21, 95% CI: 0.94–1.54).

Examining nominally significant DEGs with a log fold-change (FC) exceeding 1.5 revealed four additional genes, including Depp1 (female-upregulated, logFC 2.3, p < 4 × 10 −3 ) and Avpr1b (female-upregulated, logFC 2.13, p < 2 × 10 −3 ).

The CERS2 variant rs267738 previously associated with RRD ( 16 ) shows nominally significant association, P -value = 4.2 10 −3 , with the major T allele increasing risk as previously reported.

No such effect was observed across comparison arms, leading to a nominally significant single nucleotide polymorphism×treatment interaction ( P = 4.3 × 10 −3 ).

Regarding the 1000 Genomes Project global subjects, the SDS-identified top SNPs in ADH clusters and BRAP-ALDH2 showed nominally significant excess of DAF heterogeneity ( P < 0.0044 for DAF heterogeneity enrichment test; Table 1 and Fig. 4a ).

After normalizing for the difference in sequence context between the datatypes, we found a difference in the proportion of a 5′ CCG 3′ → 5′CTG 3′ mutational signature that was nominally significant in our South Asian ancestry study compared to those from the European studies (ratio 1.35, p = 0.0044) (Fig. 3b ).

However, the G-G haplotype of IRF6 was nominally significant with NSCL/P ( p = 0.0046) and is worthy of consideration for another independent replication study in the future.

Among these, only the ATAC-seq regions that were decreasing in accessibility had a nominally significant (p value = 0.00463) less than expected presence for ADHD, and this effect was not present when the regions are extended by either 1 kb or 10 kb.

Although the GO annotation term includes both positive and negative regulators of Wnt signaling, the pathway “negative regulation of canonical Wnt signaling” is also nominally significant for the biased downregulation of freshwater alleles (7/7 genes, Fisher's exact test, P = 0.0048), suggestive of the biased Wnt inhibition in marine fish ( figs. 3 D and E ).

Nominally significant associations between eyeAge and both COPD (p-value = 0.0048) and myocardial infarction (p-value = 0.049) were observed ( Supplementary file 3 ).

Of the remaining three genes, MORC1 and CSRNP3 showed a nominally significant association with MDD ( P =0.00483 and 0.03139, respectively).

In the Results, in the “Part B cohort with infantile-onset SMA: neurodegeneration” section, the text “...compared with the ENDEAR matched sham group (30% reduction)” has been corrected to “...compared with the ENDEAR matched sham group (32% reduction)”, and “nominally significant P = 0.0050” has been corrected to “nominally significant P = 0.0075”.

Before the Bonferroni correction, D3S1358 had a nominally significant p -value ( p = 0.0050), but this did not meet the corrected threshold of α = 0.0022.

G2 had nominally significant overrepresentation of genes attributed to CD8 + T cells ( P = 0.005), central memory T cells ( P = 0.02), Th2 cells ( P = 0.05), and eosinophils ( P = 0.03) ( Figure 1A and Supplemental Figure 4 ).

Likewise, for Alzheimer’s disease, 14.4% of the top 250 disease SNPs are nominally significant for longevity, which is more than the 8.4% that would be expected by chance (1.7 fold enrichment; P < 0.005).