“nominally significant”

No correlation reached the significance threshold of p < 0.05 after adjusting for depressive symptom severity, age, sex, and years of education, although some nominally significant correlations were observed in a few brain regions before adjustment.

Of these, a nominally significant association was observed for rs1561198 ( VAMP5 / VAMP8 ) with IL-6 and calprotectin; rs17609940 ( ANKS1A ) with C3; rs2075650 ( TOMM40 , APOE ) with hs-CRP and IL-6; rs264 ( LPL ) with C3; and finally rs599839 ( SORT1 ) with fibrinogen.

In addition, several nominally significant associations were noted with SBP and DBP among normotensives but none were statistically significant.

Third, only nominally significant P values were obtained from ZFHX1B rs13382811 in longitudinal analysis.

Ten loci showed nominally significant effects in the HUNT study in accordance with the expected statistical power (Supplementary Data 9 ).

In a study using the TEDS sample at age 7 ( Meaburn, Harlaar, Craig, Schalkwyk, & Plomin, 2008 ), an initial discovery stage based on “pools” of DNA from low- and high-reading-ability groups ( n = 750 in each group) identified 10 nominally significant SNPs that replicated in a second TEDS subsample of individually genotyped individuals.

Markers associated with phenotype traits either at ‘close to genome-wide significant’ p-values or at ‘nominally significant’ p-values Results from tests of association pointed to only one risk variant (namely Chr15:40531386-rs12440118 from ZNF106 ) associated with HbA1c emerging at ‘close to genome-wide significant’ p-value of 3.41E-08 (with Benjamini–Hochberg FDR p-value of 0.0032) ( Table 2 ).

Although there was a nominally significant negative correlation between the increase in connectivity in the cluster and the ADAS-Cog scores, this correlation did not survive Bonferroni-correction for multiple comparisons (see Figure 6 ). 4.

Female BMI was only nominally significant.

(2011) in relation to urinary arsenic species and observed nominally significant differential promoter DNA methylation in 812 unique genes, of which the majority were hypomethylated compared with relative urinary arsenic metabolite species.

3.4 Functional enrichment analysis Functional enrichment analysis was performed on all nominally significant metabolites from comparative analysis in normal and disrupted CR separately.

SKAT required 15FC × 10FNC to report nominally significant p -values, GSKAT required 20FC × 5FNC to report statistically significant p -values, FarVAT-CALPHA did not generate significant p -values unless we used the BLUP correction; FarVAT SKATO reported p -values that were significant at 15FC × 10FNC, and at 5FC × 20FNC if we used the BLUP correction.

By contrast, while the associations for D2S441– C1D , CSF1PO– TIGD6 , and FGA– PLRG1 are significant in the cumulative dataset, within subpopulations, we observed no significant or nominally significant correlations ( SI Appendix , Supplemental Table 2 ).

A 2-sided p <0.05 was considered nominally significant with no adjustment for multiple testing.

In monozygotic twin studies, hypomethylation of all MAOA CpG sites has been negatively associated with depressive symptoms, but not with childhood trauma; whereas, hypermethylation of the MAOB gene shows a nominally significant association with childhood sexual abuse ( 134 ).

The criteria for prioritization were a nominally significant association p-value (< 0.01) in the sequencing data or because the variant was not present in three catalogs of human variation (dbSNP build 137, ESP 6500 release, and 1000 Genomes April 2012 release).

However, in a combined analysis of both family-based samples, three CNVRs presented at least nominally significant CNVR-adjusted one-sided P -values (≤0.025; Table 2 ).

The haplotype analysis revealed several nominally significant associated haplotypes in spite of low frequencies.

Overall selectivity of KT777 knockdown ( KCNT1 downregulated at an adjusted P value ( P adj ) = 1.7 × 10 −34 ; 11 additional downregulated genes nominally significant at P adj < 0.05; Supplementary Table 5 ) was similar to that of RNase H-activating ASOs BIIB067 and HTTRx (targeting SOD1 and HTT , respectively) (Supplementary Figs. 1 and 2 ).

Thus, although nominally significant, these signals may be underpowered and should be regarded as exploratory pending replication.

We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: −0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it.

S 3 for illustration purposes, and the ROIs showing nominally significant group differences and their corresponding Gordon networks are listed in Table S 1 .

However, only two of the associations, quinolinate and the ratio of quinolinate with the unnamed metabolite X—16397, remained nominally significant after including eGFR into the model.

Briefly, the predefined statistical criteria used to identify biomarkers of potential interest included: a fully adjusted, significant (false discovery rate of ≤0.05) prospective association with VTE in the tofacitinib treatment arm(s) or a nominally significant association in conjunction with a fully significant treatment effect (tofacitinib vs TNFi) on the change in biomarker levels in a direction matching the association with VTE risk.

For the analysis of the druggable genes, we conducted an exploratory analysis by focussing on genes that were nominally significant in at least one TWAS analysis.