“nominally significant”

A two-sided P < 0.05 was considered as nominally significant.

Among the four major LPA molecules with the highest concentrations (>0.1 μM), only 20:4-LPA alone did not show a nominally significant association.

All other candidate genes remained at least nominally significant after dropping the most significant variant (see Supplementary Table 11) ( 14 ).

Raw p-values were adjusted for multiple comparisons using the Benjamini-Hochberg method separately for each matrix; we considered raw p-values <0.05 as nominally significant, and adjusted p-values (q) < 0.05 as statistically significant.

63 A similar approach on 148,508 individuals, of whom 22,080 had at least one parent with AD/dementia or AD diagnosis themselves, found a nominally significant enrichment of rare ABCA7 variants in disease, although an OR was not reported. 64 Power in this cohort to find significance may have been decreased by the proxy approach in which not all 22,080 AD‐classified individuals actually developed AD, carried risk variants or may have had parents with other types of dementia.

We found only 5 nominally significant SNPs in common between the Scandinavian material and the WTCCC material (see Table S1 ), indicating heterogeneity between the two samples.

Among the 29 lipids that showed nominally significant associations, only four showed an inverse association.

A heatmap of the 100 top nominally significant differentially expressed genes (DEG) demonstrated visible differences between adipocytes in 3% vs. 5% gels ( Figure 3c , Table 1S).

Although this is only nominally significant, it is notable that these genes are in the 3rd percentile of schizophrenia associations genome-wide within UK Biobank.

We found nominally significant global genetic correlations among six trait pairs identified by both LDSC [ 13 ] and ρ-HESS [ 20 ] (FEV 1 and FVC with PUD, GORD, and IBS, Fig. 2 and Additional file 1: Table S2 ).

The significance threshold was set to 0.0025 and p -values below 0.0025 were considered statistically significant, while p-values between 0.0025 and 0.050 were considered nominally significant.

After Bonferroni correction for multiple testing, p-values less than 0.0125 were considered nominally significant.

Neither of these effects reached study-wide significance after correction for multiple comparisons using a permutation test. Additionally, we found nominally significant associations between several supplementary self-report measures and AVPR1A rs1042615 or OXTR rs237889 (see Supplementary Table 2 for the full results).

Of these, a nominally significant association was observed for rs1561198 ( VAMP5 / VAMP8 ) with IL-6 and calprotectin; rs17609940 ( ANKS1A ) with C3; rs2075650 ( TOMM40 , APOE ) with hs-CRP and IL-6; rs264 ( LPL ) with C3; and finally rs599839 ( SORT1 ) with fibrinogen.

Third, only nominally significant P values were obtained from ZFHX1B rs13382811 in longitudinal analysis.

We counted how many times nominally significant enrichment of a given GO term was observed, and the probability to see significant enrichment among 10 000 trials was considered as the P -value.

In a study using the TEDS sample at age 7 ( Meaburn, Harlaar, Craig, Schalkwyk, & Plomin, 2008 ), an initial discovery stage based on “pools” of DNA from low- and high-reading-ability groups ( n = 750 in each group) identified 10 nominally significant SNPs that replicated in a second TEDS subsample of individually genotyped individuals.

Markers associated with phenotype traits either at ‘close to genome-wide significant’ p-values or at ‘nominally significant’ p-values Results from tests of association pointed to only one risk variant (namely Chr15:40531386-rs12440118 from ZNF106 ) associated with HbA1c emerging at ‘close to genome-wide significant’ p-value of 3.41E-08 (with Benjamini–Hochberg FDR p-value of 0.0032) ( Table 2 ).

Although there was a nominally significant negative correlation between the increase in connectivity in the cluster and the ADAS-Cog scores, this correlation did not survive Bonferroni-correction for multiple comparisons (see Figure 6 ). 4.

Female BMI was only nominally significant.

(2011) in relation to urinary arsenic species and observed nominally significant differential promoter DNA methylation in 812 unique genes, of which the majority were hypomethylated compared with relative urinary arsenic metabolite species.

Of the 16 reliably detected miRNAs, 3 (miR-15b, -132, and -652) showed a nominally significant increase in expression in the high-risk subjects compared to the control subjects (miR-15b, FC = 1.29; miR-132, FC = 1.34; miR-652, FC = 1.26).

SKAT required 15FC × 10FNC to report nominally significant p -values, GSKAT required 20FC × 5FNC to report statistically significant p -values, FarVAT-CALPHA did not generate significant p -values unless we used the BLUP correction; FarVAT SKATO reported p -values that were significant at 15FC × 10FNC, and at 5FC × 20FNC if we used the BLUP correction.

By contrast, while the associations for D2S441– C1D , CSF1PO– TIGD6 , and FGA– PLRG1 are significant in the cumulative dataset, within subpopulations, we observed no significant or nominally significant correlations ( SI Appendix , Supplemental Table 2 ).

A 2-sided p <0.05 was considered nominally significant with no adjustment for multiple testing.