“nominally significant”

Pairwise comparisons using Fisher’s exact test show P = 0.042 (nominally significant) between full-length MYO7A and MYO7A-RK/AA on the formation of protein blobs at stereocilia tips (Supplementary Fig. 3a ).

A P-value of less than 0.05 was considered nominally significant.

18 However, this inconsistency was nominally significant, and a complementary analysis confirmed benefits of semaglutide versus placebo across a continuum of BMI values. 18 As the current pooled post hoc analysis included data for OW s.c. and OD oral semaglutide from the SUSTAIN 6 and PIONEER 6 CVOTs, respectively, our findings on consistent risk reduction of CV outcomes regardless of baseline BMI support previous conclusions.

The nine nominally significant lipids showed opposite directions of change between the two comparisons (Fig. 2 D, upper panel).

None of the nominally significant associations remained statistically significant after applying the Bonferroni correction.

Among the 7 metabolites identified in the primary analysis, most remained nominally significant after additional covariate adjustment and in restricted analyses, with complete directional concordance (Supplementary Data 1 ).

Overall, 35 (62.5%) of the associations were nominally significant.

KEGG pathway analysis was performed on all of the nominally significant DMRs to identify pathways associated with stress.

Although several genes showed nominally significant associations with overall survival, the corresponding hazard ratios displayed wide confidence intervals, reflecting the limited sample size and small number of mutation-positive cases.

Our results, although nominally significant, were not significant after correcting for multiple comparisons.

Ninety-eight of the six hundred nine investigated microRNAs showed nominally significant P -values, suggesting that BD-associated microRNAs might be enriched within known microRNA loci.

All statistical tests were two-sided, with p -values < 0.05 considered nominally significant.

Discussion Genes harbouring markers with only modest evidence of association (nominally significant but not reaching the genome-wide significance threshold) can be identified if they belong to the same biological pathway or mechanism; therefore, pathway-based approaches, which jointly consider multiple variants in interacting or related genes, might complement the most-significant SNPs/genes approach for interpreting genome-wide association (GWA) data on complex diseases [ 7 , 8 ].

Although only one estimate was still significant after the Bonferroni correction, other nominally significant estimates should also be treated carefully.

In fact, the study of nominally significant genomic loci in the meta-analysis has shown that pathways related to aggregated amyloid-β, tau protein, and inflammatory pathways could be related to PH occurrence. 2.

A nominally significant difference in OS in favor of patients randomized to eribulin compared with control in patients with bone, lymph node, and chest wall/breast/skin metastases at baseline was observed.

A cut-off p value <0.01 was used to retrieve nominally significant SNPs.

Finally, in humans, OX2R polymorphisms affect morningness–eveningness, napping, and reports of excessive daytime sleepiness, while OX1R polymorphisms have smaller but nominally significant effects on sleepiness and napping, based on numerous studies and data in the Sleep Disorder Knowledge Portal ( https://sleep.hugeamp.org/ ) ( 40 – 43 ).

A nominally significant Acute Physiology and Chronic Health Evaluation IV (APACHE IV) × LAR interaction (hospital mortality, P for interaction=.02) indicated stronger LAR prognostic effects in lower-severity patients (APACHE IV≤70), representing within-biomarker effect modification requiring prospective validation.

The cytochrome P450, cell cycle control, and alcohol dehydrogenase candidate genes groups also exhibited nominally significant (0.01<P permuted <0.05) associations with smoking behaviors ( Table 4 ).

Oestrogen plus progestin reduced the observed hip and clinical vertebral fracture rates by one third compared with a placebo, both nominally significant.

ECM1 had consistent associations with genetically predicted SCAD across both data sets, which were statistically significant, whereas SPON1 was only significant in UKB, despite consistency in direction of association, which was nominally significant before correction for multiple testing.

The other nominally significant interactions included CD2AP (rs9296559) x PICALM (rs3851179), CLU (rs11136000) x PICALM (rs3851179), and CLU (rs11136000) x MS4A6A (rs610932).

However the result for rs3748816 remains nominally significant even if corrected for the number of tests performed in the original screen.

To further assess the relevance of driver meQTLs to cancer risk, we used them to predict breast cancer status alongside clinical covariates using the approach described by Elgart et al . 18 We first performed feature selection by LASSO on nominally significant driver meQTLs and available clinical factors (age, ancestry as represented by the top 10 genotype-derived PCs); LASSO regularization removed ancestry and some meQTLs.