“nominally significant”

For both conditions, merely 2 out of 48 specifications yielded nominally significant outcomes, which means that evidence for any beneficial effects of KV448 or other music on epilepsy seems doubtful.

Robust gene signatures of kidney aging and their correlation with functional and structural dimensions of kidney health Of 19 replicated genes, 14 showed at least 1 nominally significant association with 1 of 5 biochemical or histologic measures of renal functional and structural integrity known to deteriorate with age (i.e., estimated glomerular filtration rate, glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arterial/arteriolar narrowing) in up to 160 individuals from the TRANSLATE Study ( Supplementary Tables S10–S14 , Figure 2 , and Supplementary Figure S2 ).

Both scores of bone-mineral density (in the femoral neck and in the lumbar spine) are nominally significant, suggesting a protective effect for AMD in individuals having a higher bone-mineral density.

Although each of these associations was nominally significant, neither reached the prespecified Bonferroni-adjusted P value.

As for the Wnt agonist RSPO3, we found nominally significant lower levels in SCZ, and no significant differences in BD compared to HC.

Analyses over the intervention period and the cumulative follow-up identified nominally significant intervention benefits related to breast cancer ( 5 , 6 ), CHD ( 7 ), and diabetes ( 8 ).

Results Eighteen immune cell signatures were found to have nominally significant associations with VTE according to the IVW method.

A p < 0.05 was reported as nominally significant, and a Hochberg correction ( Hochberg, 1988 ; Huang and Hsu, 2007 ) was applied to determine statistical significance in the context of multiple comparisons within a given genotype and time-period of interest.

Two nominally significant negative correlations were observed, both for NRG3 (not different from the 1.1 negative correlation expected by chance in 44 tests, underlined in Table 1 ).

All three meta-analysis two-sided tests (fixed effects, random effects, and weighted Z -score) were all nominally significant in both BD and SCZ groups (Table 1B ).

We also observed nominally significant changes in PD and DLB with co‐existing AD pathology across the amplicon, but these did not pass multiple correction.

EXSCEL reported a nominally significant reduction in all-cause mortality (HR: 0.86, 95% CI: 0.77-0.97) despite a neutral primary efficacy result [ 17 ], and PIONEER 6 showed lower cardiovascular and all-cause mortality (all-cause death, HR: 0.51, 95% CI: 0.31-0.84), albeit on a small number of events [ 19 ].

In the UKB data, interactions of rs161070 from the PEX3 gene and rs7176881 and rs117778159 SNPs from the EIF2AK4 gene showed nominally significant associations with ST.

In the phase 2 study of tirasemtiv, no efficacy signal was seen in ALSFRS-R, although a key secondary end point, SVC, showed a nominally significant benefit. 9 , 11 , 12 SVC was the primary end point of the phase 3 tirasemtiv study; negative results were believed to reflect poor tolerability, as a per protocol post hoc analysis again suggested a benefit. 11 In the FORTITUDE-ALS trial, the phase 2 study of reldesemtiv, SVC was the primary outcom

have previously reported a nominally significant association between this SNP and a narrow ASC diagnosis in family-based samples [ 27 ].

The FDR-adjusted P was presented by “ q ”, and the results were considered as nominally significant if q < 0.10.

APOB, APOC3 and its subfractions (heparin precipitate, heparin-soluble [HS]) and apolipoprotein-defined lipoprotein subclasses–classified Lp-B were associated with any-CVD in unadjusted analyses, and association of APOC3-HS remained nominally significant in adjusted analyses.

Any complication and acute kidney injury were nominally significant in the matched cohort, while only any complication remained significant after false discovery rate correction.

Comparing to the background of random genetic variants in CEU in all of HapMap Phase II, 4 SNPs in AHI1 and 8 in GPR56 exceeded the 99th percentile with nominally significant P -values (Fig. 3 A and Supplementary Material, Table S1a ).

In the RCT, nominally significant placebo-adjusted differences in LS mean change from baseline to end point on the ADHD-RS-IV were observed in GXR-treated participants, in both subgroups (prior MPH, −9.8 [95% CI −14.6 to −5.1], P <0.001, ES 0.85; stimulant-naïve: −7.6 [95% CI −11.8 to −3.3], P <0.001, ES 0.65).

Finally, uncorrected p values were reported with corrected values to improve transparency, but nominally significant findings should be viewed as hypothesis-generating.

Pairwise comparisons using Fisher’s exact test show P = 0.042 (nominally significant) between full-length MYO7A and MYO7A-RK/AA on the formation of protein blobs at stereocilia tips (Supplementary Fig. 3a ).

A P-value of less than 0.05 was considered nominally significant.

18 However, this inconsistency was nominally significant, and a complementary analysis confirmed benefits of semaglutide versus placebo across a continuum of BMI values. 18 As the current pooled post hoc analysis included data for OW s.c. and OD oral semaglutide from the SUSTAIN 6 and PIONEER 6 CVOTs, respectively, our findings on consistent risk reduction of CV outcomes regardless of baseline BMI support previous conclusions.

The nine nominally significant lipids showed opposite directions of change between the two comparisons (Fig. 2 D, upper panel).