“nominally significant”

Among the eight other previously reported association signals, all were directionally consistent with our study, but only rs8105767 ( ZNF208 ) was nominally significant (P=0.003).

When examining the genetic overlap between thyroid hormones and sex hormones, we observed suggestive, nominally significant positive genetic correlations between testosterone and both FT3 ( p = 3.00 × 10 −3 ) and FT4 ( p = 7.90 × 10 −3 ), as well as a Bonferroni-significant positive genetic correlation between FT4 and SHBG ( p = 2.00 × 10 −4 ); we additionally observed a suggestive negative genetic correlation between testosterone and TSH ( p = 4.50 × 10 −3 ). 3.3.

Although the results did not survive Bonferroni correction, nominally significant enrichments were observed for platelet sensitization by low-density lipoprotein cholesterol ( p = 0.003), IL-7 signaling ( p = 0.004), glycerophospholipid biosynthesis ( p = 0.005), and viral messenger RNA synthesis ( p = 0.011) ( Figure 2 and Supplementary Table 5 ).

For tremor, the top scoring model from this subchallenge (yuanfang.gaun) showed only one nominally significant subject (1046, p-value = 0.003), and the cross-subject meta-analysis was not significant after multiple test correction (unadjusted p-value = 0.047).

Before false discovery rate (FDR) correction, several network pairs showed nominally significant associations with apathy, including VI–VI ( r = − 0.214, P = .003), VI–VII ( r = 0.203, P = .006), SubC–SubC ( r = 0.152, P = .039), and SubC–VII ( r = 0.151, P = .041).

11 , 12 Other investigators have determined that the −521 C>T and 120 bp tandem repeat (TR) polymorphisms in DRD4 are associated with nominally significant summary odds ratios (ORs) as risk factors for schizophrenia ( P =0.003 and 0.005, respectively). 11 However, despite a great deal of research, an association between DRD4 polymorphisms and schizophrenia risk remains debatable.

S1 ) and even succeeded in replicating the nominally significant difference between NG and IFG groups in has-let-7a levels (p = 0.003, FC = 0.97) and the borderline significant result in hsa-miR-144-5p levels (p = 0.061, FC = 0.91) in the same setting.

rs3818361 ( CR1 ) and rs3764650 ( ABCA7 ) both showed nominally significant differences compared with controls ( CR1 OR = 1.7 [1.20–2.41], P = .003, P GC = .004; ABCA7 OR = 1.83 [1.17–2.86], P = .009, P GC = .01).

Nominally significant associations were observed in elderly participants (OR 1.68, 95% CI 1.20–2.37, p = 0.003), men (OR 1.40, 95% CI 1.06–1.86, p = 0.018), and patients with hypertension (OR 1.55, 95% CI 1.14–2.11, p = 0.005).

Nominally significant adverse associations were observed in eight strata on unadjusted testing: an age below the cohort median of 72 years (HR 2.08, 95% CI 1.28–3.38; p = 0.003), an age of 72 years or older (HR 1.98, 95% CI 1.33–2.96; p < 0.001), female sex (HR 2.21, 95% CI 1.18–4.16; p = 0.013), male sex (HR 1.91, 95%

highlights probes on HIP1 , LMAN2 , and MOBP genes, however, in our setup the most significant probes on HIP1 and LMAN2 genes were only nominally significant (cg08710628 on HIP1 , P = 0.003; cg05408837 on LMAN2 , P = 0.008), whereas no probes on MOBP were significant.

Of the 100 targeted IR genes, 40 were shown to have significant SNPs (uncorrected p < 0.05), including the gene FCAR , which was nominally significant ( p = 0.0031).

T ‐statistics and uncorrected p ‐values are shown, bolded p ‐values are those that survive correction for multiple comparisons, italicized p ‐values are those that do not survive multiple comparisons correction but were nominally significant (i.e., .05 > p > .003125).

Abdominal subcutaneous adipocyte area was nominally significant among different NAFL groups ( p =0.0034), with post-hoc analyses indicating a significant increase between NAFL 0 and NAFL 2 ( p =0.005) and trending increases between NAFL 0 and NAFL 1 ( p =0.052) and NAFL 1 and NAFL 2 ( p =0.054) ( Figure 2A ).

Nominally significant methylation differences were observed (i) between carriers vs. non-carriers at cg11481443 (standardized regression coefficient = −0.306, p = 3.4 × 10 –3 ; Additional file 6 : beta-value and M value plots) and cg02936398 (standardized regression coefficient = 0.177, p = 4.9 × 10 –2 ; Additional file 6 : beta-value and M value plots); (ii) hATTR patients and asymptomatic carriers at cg14311811 (standardized regression coefficient = −0.273, p = 3.8 × 10 –2 ; Additional file 6 : beta-value and M value plots).

GNAS , which showed a nominally significant loss in population-level AI with age (LRT P =3.4×10 −3 ), also showed a significant decrease in individual-level AI with age.

Relationship Between the Sub-Dimensions of the SCOOHPI Scale and Demographic and Clinical Variables According to the study of the relationship between the three dimensions of the SCOOHPI scale and the sociodemographic and clinical variables, we find that only the third dimension (Activity and Organization) showed a nominally significant association with the DMFT index before correction for multiple comparisons ( p = 0.0035).

2B , none of the PCM genes reached the genome-wide significance level, though nine genes had nominally significant P -values: DNM1 (MAGMA P = .0035), RERE ( P = .015), FOXP1 ( P = .018), NCL ( P = .019), CUL3 ( P = .024), NASP ( P = .027), KCNMA1 ( P = .03), SETD2 ( P = .044), and MBD5 ( P = .048).

Results In the China subgroup ( n = 432; 22.7% of the KRONOS population), BGF MDI demonstrated nominally significant improvements in the primary endpoint versus BFF MDI (least squares mean (LSM) difference 68 mL; P = 0.0035) and BUD/FORM DPI (LSM difference 78 mL; P = 0.0010) but not GFF MDI (LSM difference − 4 mL; P = 0.8316).

The HRs were nominally significant in LOADFS ( p = 3.54E−03) and CHS ( p = 2.19E−02).

The gene-wise set test for the association of FMR1 with QIDS-SR was nominally significant with P=.0036, a probability which does not meet Bonferroni criteria for 36 genes tested (see Additional file 1 , sheet 2).

We detected nominally significant enrichment for islet eQTLs for variants associated with continuous glycemic traits (normalized enrichment score (NES) = 1.27; P = 3.7 × 10 −3 ; Supplementary Fig. 9 and Supplementary Data 14 ): of all the tissues considered, islets generated the most significant enrichment for this phenotype.

We achieved a nominally significant signal only for rs11870474 at the ATP5H / KCTD2 locus (OR=1.43, 95% CI (1.12–1.83), P =0.0038).

A nominally significant negative correlation with K (r = −0.57, raw p = 0.0039) was also observed, though this did not survive correction.

LBC1921 Childhood cognitive ability in LBC1921 There was a nominally significant association between three SNPs and age 11 Moray House Test (MHT) score: CTSZ , rs9760 (F = 5.625, p = 0.004, η 2 = 0.025); GSTZ1 , rs3177429 (F = 4.820, p = 0.009, η 2 = 0.022); NDUFS4 rs31304 (F = 9.757, p = 0.002, η 2 = 0.022).