“nominally significant”

2015) (p,p′-DDE and T-NONA) was detected; nor did we observe the positive nominally significant association between PCBs and ASD outcome (Lyall et al. 2015) in our analyses parameterizing exposure continuously ( Table 1 ).

Nominally significant baseline factors associated with a higher risk of any-CVD included the secondary versus primary cohort, older age, greater weight and BMI in women but not in men, smoking, longer duration of diabetes, family history of MI and type 2 diabetes, higher blood pressure and pulse, and higher total cholesterol, triglyceride, LDLc, and HbA 1c levels.

Three probes from the ESTHER/KORA study 12 and 1 from the twin study 11 were nominally significant in our study, using a fully adjusted model, in both the discovery and validation cohorts (Table S2 ), but they were no longer significant after FDR adjustment.

The study identified 33 nominally significant loci, of which a subset of 9 loci were defined as being genome wide significant by permutation testing (1 locus in greyhounds, 6 loci in Rottweilers and 2 loci in Irish wolfhounds).

In addition to the consumption of red meat and fish, several other nutritional phenotypes were nominally significant, therefore, we used the principal component analysis (PCA) based on food consumption-related phenotypes (fish, red meat, salt, sugar, vegetable intake, and leptin) to investigate differences in food pattern between DLSS and controls (Fig. 2 A).

While this association was nominally significant in the multiple imputation analysis, the effect size was smaller among females and did not meet the threshold after adjusting for multiple comparisons [β = 0.23, 95% CI (0.01–0.14), q = 0.34].

Given the association of CGI shores with tissue-specific methylation [ 19 ], we extended our search to CGIs including +/- 1 kbp of flanking sequence, which yielded sets of nominally significant motifs [see Additional file 2 : Figure S1.A].

A two-sided P value of <0.05 was considered nominally significant.

Of the 1200 possible variant and tissue combinations (25 variants x 48 tissues), approximately half showed nominally significant associations (Supplementary Data 4 ).

Moreover, we found 2,917 nominally significant pairs, a 3.4-fold increase in what would be expected under the null hypothesis of random overlap (expected 857.6 of 17,152 disease-principal component pairs at a 0.05 rejection rate).

Although previous GWAS reported a nominally significant sexual dimorphism for rs4646404 [ 7 ], we found no sex–SNP interaction effects in the linear regression analyses in the present study.

Complementary analysis of the functional capacity of the microbiome using the GMMs ( Figure 2 A right panel) revealed nominally significant associations for birthweight z-score and labor antibiotics at TP1, though these relationships did not remain significant after adjustment for multiple comparisons.

Associations of Individual SNPs With VTE As shown in Table 4 , only the Leiden mutation (rs6025) and rs2066865 (FGG) were significantly associated with VTE risk and found to be nominally significant for the Roma population, but not for the general population.

During the validation phase in the UK Biobank Chinese cohort, 12 novel SNPs were found to be nominally significant for lung function, including two in the TBC1D16 gene, one in the TAFA5 gene, and one in the MTHFD1L gene.

Although not achieving P adj ≤0.05, identification of the Th2 pathway ( P = 1.22x10 -3 ; P adj = 0.074; z-score -0.82) and Activation of Th1 and Th2 Pathway ( P = 1.32x10 -3 ; P adj = 0.074) as nominally significant canonical pathways is consistent with prior knowledge of immune responses to leishmaniasis.

Although the unstable repetitive sequence is linked with one of the three more commonly prevalent haplotypes, statistics point to a nominally significant likelihood that our observation reflects a founder effect rather than coincidence by chance.

Assuming that many of these nominally significant results likely represent false positives, we focus on the eight correlations that emerged in at least 5% of the simulations.

Only nominally significant associations were included (multiple comparison correction was not performed).

Results Association analysis in sorbs We observed nominally significant associations with disinhibition at the variant rs10232478 located in the 5′ untranslated region and the intronic SNPs rs1834150 and rs782881 (Table 2 ).

The nominally significant are summarized in Additional File, Supplementary Material, Table S3 .

In the stage I association study of allergic conjunctivitis, we selected 5 SNP in the TEK gene with nominally significant p-values.

17 The metabolites with fold change ≥1.5 or ≤0.67 and p < 0.05 in t ‐test were considered nominally significant, and the metabolites with false discovery rate (FDR) < 0.05 were considered statistically significant.

While several markers were nominally significant at an alpha level of 0.05 (e.g. miR-155-5p for lung cancer), they were not significant following adjustment for multiple testing.

All biomarker analyses were exploratory; two-sided p -values < 0.05 were considered nominally significant without adjustment for multiplicity.

In accordance with earlier reported diet-CRC association, three metabolites, reflecting fiber and wholegrain, and fruit and vegetable intake, showed nominally significant associations to decreased CRC risk, whereas one alcohol-related metabolite showed a nominally signification association to increased CRC risk.