“nominally significant”

The linear trend became stronger and was nominally significant for GS-PS compared to original-PS for cancer mortality in women.

We found more loci with nominally significant covariance with IBD (at p -value thresholds of .01 and .05) for both HADS scale models ( Supplementary Figure S10A ).

All statistical tests were two-sided; p < 0.05 was considered nominally significant, though given the small sample sizes and ecological design, all p -values should be interpreted with caution [ 9 , 10 , 11 , 12 ]. 2.4.

Gene associations with p-values less than 0.05 were considered nominally significant.

Nominally significant associations were obtained for mismatch repair genes ( MLH1, MSH2, MSH6, PMS2 ) in all PC patients, however, variants in ATM, CPA1 , and PMS2 were only observed in CDKN2A wild-type PC patients.

AA isoleucine, apolipoprotein A1, and total cholines were not only associated with baseline kidney measures (P FDR < 0.05) but also showed stable, nominally significant association with incident CKD and decline.

The residuals were approximately normally distributed with a zero mean and constant variance. Individual Data Among three individual data predictor variables (age, biological sex, and prior psilocybin experience), only age showed correlation with DED, which was nominally significant.

Higher baseline GFAP was associated with faster longitudinal increases in ventricular volume ( P < 0.0001), and a nominally significant association with steeper declines in amygdala volume which did not survive FDR correction for multiple comparisons.

Approximately 15% (13% to 17%) of genes in each pathway had nominally significant gene-level associations with resilience ( Table 2 ).

All nominally significant results survived the FDR procedure.

In ER-negative disease, CD20 + TIICs were associated with a better prognosis in partially adjusted models, but the effects were slightly attenuated in the fully adjusted models, with the association being nominally significant only for the stromal compartment.

Species that were FDR-significant in all 4 models in the discovery sample and were at least nominally significant for localized disease experience in MTG data were termed “significant species”.

Nominally significant association results for these same two variants were also seen in sensitivity analyses for the contrast of Active TB to no LTBI, and also Active TB to LTBI (Supplementary Tables S4 and S5), providing support that these variants are associated with increased risk for TB.

Thus, SNPs with nominally significant p-values are presented, and False Discovery Rate (FDR) multiple testing correction was applied [ 23 ].

Two vortioxetine doses were investigated because both 10 mg and 20 mg demonstrated nominally significant improvements in MADRS total score and response rate, and acceptable tolerability, in the secondary analysis of a randomized, placebo-controlled, multinational, 8-week, phase 2/3 trial of vortioxetine that included Japanese participants with MDD. 24 After the treatment period, study drugs were subsequently withdrawn, at which point patients entered a 4-week safety follow-up period for the analysis of outcomes of adverse events.

Despite most of our analyses suggesting a stronger contribution of maternal, than fetal common genetic variants to GWG, the one nominally significant variant that replicated was for a fetal variant that was related to total GWG.

We found nominally significant negative correlations of D f with C-reactive protein ( r g = −0.13 ± 0.05), atherosclerosis ( r g = −0.24 ± 0.03), coronary artery disease ( r g = −0.12 ± 0.06), stroke ( r g = −0.23 ± 0.09), and a positive correlation with longevity ( r g = 0.12 ± 0.06) (table S7).

This is so even if in some studies (mainly retrospective, post hoc or using predefined but nominally significant ‘secondary’ outcomes) it seems that the mortality rates are reduced by the achievement of certain targets or the use of certain drugs [ 56–61 ].

We find several nominally significant associations between rare ABCG5/8 coding variants and other CVD.

15 However, the control group—who received non-optimised dorsolateral prefrontal cortex stimulation—also showed nominally significant, though less prominent, improvements in social outcomes.

p < 0.05 is considered nominally significant. 3 Results 3.1 Genetic IVs enrolled in this study The design protocol for this study is shown in Figure 1 .

Multiple comparisons were addressed using the false discovery rate (FDR), with FDR < 0.05 considered statistically significant and FDR < 0.2 considered nominally significant. 10 Metabolite set enrichment analysis (MSEA) was used to evaluate associations between metabolite classes and hip fracture risk. 30 We calculated the normalised enrichment scores (NES), which typically range from −3 to +3, along with the FDR values in the MSEA analysis.

73 It should be noted that, in the BEST trial, a nominally significant interaction effect of therapy was found only for race (African American vs.

At week 52 of the TULIP-1/TULIP-2 treatment period, a higher proportion of patients attained DORIS remission with anifrolumab versus placebo regardless of IS history; the improved rates of DORIS remission with anifrolumab were nominally significant in both IS-inexperienced and IS-experienced patients.

We then used PanPhlAn3 47 to analyze the gene repertoire of the seven species that were detected in at least 10 tCeD cases and 10 controls and showed at least a nominally significant association between analysis group and interindividual strain distance or strain cluster distribution (see partition around medoids (PAM) clustering below).