“nominally significant”

Cumulative effect of rs1801274, rs3818298, rs2736340 and rs4813003 on KD risk Next, we examined the cumulative effect of the 4 nominally significant SNPs by counting the number of non-risk genotypes associated with KD risk in each subject according to the potential inheritance models presumed by the results of dominant and recessive models from individual SNP analysis.

Subtype Analysis In the subtype analysis, no test was significant after Bonferroni correction, but several lab values were nominally significant in both groups.

We found more loci with nominally significant covariance with IBD (at p -value thresholds of .01 and .05) for both HADS scale models ( Supplementary Figure S10A ).

One nominally significant estimate of heritability was uncovered attributing 41% of the variance in internalizing problem scores to the effects of all SNPs in the GWAS, showing that the CBCL-internalizing problem score has a significant polygenic component similar to DSM-based psychiatric disorders 6 .

Gene associations with p-values less than 0.05 were considered nominally significant.

Nominally significant associations were obtained for mismatch repair genes ( MLH1, MSH2, MSH6, PMS2 ) in all PC patients, however, variants in ATM, CPA1 , and PMS2 were only observed in CDKN2A wild-type PC patients.

Among these nominally significant probes, 77.9% (1410/1809) of the probes for CD4 + T cells and 82.5% (1520/1843) of the probes for CD8 + T cells showed lower methylation rates in the patients than in the controls.

All comparisons where the p -value was less than 0.05 by statistical testing should be regarded as nominally significant.

We additionally calculated empirical p values based on the number of nominally significant associations for each WMN-IC after permuting the WMN-IC scores 10000 times, applying FDR correction ( α < 0.05) for six independent tests.

A two‐sided p value of < 0.05 was considered nominally significant. 3 Results 3.1 Subcutaneous Fat Thickness Subcutaneous fat thickness varied across cadaver specimens and body regions.

AA isoleucine, apolipoprotein A1, and total cholines were not only associated with baseline kidney measures (P FDR < 0.05) but also showed stable, nominally significant association with incident CKD and decline.

The residuals were approximately normally distributed with a zero mean and constant variance. Individual Data Among three individual data predictor variables (age, biological sex, and prior psilocybin experience), only age showed correlation with DED, which was nominally significant.

Higher baseline GFAP was associated with faster longitudinal increases in ventricular volume ( P < 0.0001), and a nominally significant association with steeper declines in amygdala volume which did not survive FDR correction for multiple comparisons.

Approximately 15% (13% to 17%) of genes in each pathway had nominally significant gene-level associations with resilience ( Table 2 ).

All nominally significant results survived the FDR procedure.

Any other test results were not adjusted for multiplicity and any p-value ≤0.05 from those testing results was interpreted as nominally significant.

In ER-negative disease, CD20 + TIICs were associated with a better prognosis in partially adjusted models, but the effects were slightly attenuated in the fully adjusted models, with the association being nominally significant only for the stromal compartment.

Among 41 measures analyzed, none showed even nominally significant differences between treatment groups.

Post-MTT, there were no consistent or nominally significant differences between the volixibat and placebo groups in LS mean E max , AUC (0–3) or rAUC (0–3) for insulin or C-peptide; for C-peptide, there was a trend towards lower values in the volixibat groups compared with the placebo group (Table 5 and Additional file 2 : Table S1).

Likewise, nominally significant improvements compared with placebo were seen for DDS and continuous severity of illness, and descriptively better outcomes were achieved in CGI item III.

Species that were FDR-significant in all 4 models in the discovery sample and were at least nominally significant for localized disease experience in MTG data were termed “significant species”.

Of note, among the perturbed genes, of the top ten genes ranked by LoF effects on MCH, seven had nominally significant Perturb-seq effects on HBA1 , and for all seven, the sign of the Perturb-seq β matched what we predicted from γ .

Despite most of our analyses suggesting a stronger contribution of maternal, than fetal common genetic variants to GWG, the one nominally significant variant that replicated was for a fetal variant that was related to total GWG.

rs4961199 (P = 0.02) was the only SNP showing nominally significant evidence of departure from additivity in our data.

This is so even if in some studies (mainly retrospective, post hoc or using predefined but nominally significant ‘secondary’ outcomes) it seems that the mortality rates are reduced by the achievement of certain targets or the use of certain drugs [ 56–61 ].