“nominally significant”

A limitation of our study is that the potential partial mediations did not survive Bonferroni multiple comparison correction, they were only nominally significant.

For microvascular complications, we did observe a nominally significant association for the PGS of age-related macular degeneration (HR = 1.03 (1.01–1.06)), but not chronic kidney disease (HR = 1.00 (0.98–1.03); Supplementary Fig. 19 and Supplementary Table 6 ).

Strikingly, this BMI signal colocalizes with 15 BMI MR trans -eQTLs ( PP median = 0.67 [range 0.49–0.98]) and 64 BMI MR trans -aQTLs ( PP median = 0.89 [range 0.49–1.00]), though among these nominally significant, colocalized trans -QTL signals, only 8 trans -aQTLs ( ANG , CSNK2A2 , ID2 , PIM1 , PTPRJ , TENM4 , TNFRSF10C and ZFAT ) were significant at FDR < 0.05 ( Fig 4 , and Tables 1 , S11 – S15 and S17 ).

Nominally significant associations were found between goiter, aortic aneurysm, myeloma, and amyotrophic lateral sclerosis and the rs2653349 SNP.

17 This suggests that abnormalities in long-chain acylcarnitines reflect a common signature associated with myocardial mitochondrial dysfunction. The other nominally significant results included results for factor 2, comprised of long-chain dicarboxylacylcarnitines, unique in being the only factor which was only different in CpcPH compared to controls.

Conclusions The detected nominally significant associations between state-anhedonia and genetic variants from GRM5 gene strengthen previous assumptions about the possible relationship between glutamatergic system and anhedonia.

However, by examining the nominally significant genetic locus associated with the metabolite on chromosome 10 (BP 60,794,328-61,050,339), nearby genes and phenotypes associated with those genes were identified (genes included PHYHIPL , TRAF6P1 , LINC00844 , and FAM13C ; phenotypes included DNA methylation, sleep duration, and QT-interval duration in Trypanosoma cruzi seropositivity).

Within module steelblue, nominally significant pathway enrichment was related to ion channel activity, membrane potential homeostasis, and vesicle transport.

None of the nominally significant pathways remained significant after correction for multiple testing.

There were several C-type associations from the top lists showing the same direction and nominally significant cis -eQTL effect in multiple tissues ( S9 Fig ).

rs705702 was not associated with PCOS in the current study and was only nominally significant in previous European studies ( 13 ).

Moreover, the c.230A>T is a specific polymorphism in East-Asian populations and exhibits nominally significant evidence for positive selection in Northern Chinese populations.

While both the sQTL and hQTL are nominally significant for an eQTL association, colocalization analysis reveals that only the hQTL and eQTL are probably caused by the same genetic variant (posterior probability of full colocalization, PPFC >0.5).

These average gĉp estimates represent only Bonferroni significant relationships; however, each trait pair listed was nominally significant after conditioning with all other EDU and SES phenotypes but not significant in the unconditioned experiment ( Table 1 ).

Regardless of reading performance, subjects with READ1d showed nominally significant lower global efficiency, local efficiency, and clustering coefficient compared to subjects without READ1d, with consistent effect directions across metrics; the nodal analysis revealed a significant effect of READ1d on a network spanning lateral, occipital and frontal cortex.

Cumulative effect of rs1801274, rs3818298, rs2736340 and rs4813003 on KD risk Next, we examined the cumulative effect of the 4 nominally significant SNPs by counting the number of non-risk genotypes associated with KD risk in each subject according to the potential inheritance models presumed by the results of dominant and recessive models from individual SNP analysis.

Subtype Analysis In the subtype analysis, no test was significant after Bonferroni correction, but several lab values were nominally significant in both groups.

We found more loci with nominally significant covariance with IBD (at p -value thresholds of .01 and .05) for both HADS scale models ( Supplementary Figure S10A ).

Gene associations with p-values less than 0.05 were considered nominally significant.

Nominally significant associations were obtained for mismatch repair genes ( MLH1, MSH2, MSH6, PMS2 ) in all PC patients, however, variants in ATM, CPA1 , and PMS2 were only observed in CDKN2A wild-type PC patients.

AA isoleucine, apolipoprotein A1, and total cholines were not only associated with baseline kidney measures (P FDR < 0.05) but also showed stable, nominally significant association with incident CKD and decline.

The residuals were approximately normally distributed with a zero mean and constant variance. Individual Data Among three individual data predictor variables (age, biological sex, and prior psilocybin experience), only age showed correlation with DED, which was nominally significant.

Higher baseline GFAP was associated with faster longitudinal increases in ventricular volume ( P < 0.0001), and a nominally significant association with steeper declines in amygdala volume which did not survive FDR correction for multiple comparisons.

Approximately 15% (13% to 17%) of genes in each pathway had nominally significant gene-level associations with resilience ( Table 2 ).

All nominally significant results survived the FDR procedure.