“nominally significant”

11 , where P < 0.05 is nominally significant; specific area significance (i.e., Specific brain thickness P < (0.05)/(11 traits*2 SNPs) = P < 0.0023.

At week 12, these increases were dose‐dependent and were significant for solriamfetol 300 mg (84.7%) and 150 mg (78.2%) doses versus placebo (39.7%; both p < 0.0001); the 75 mg dose was nominally significant (67.8%) compared with placebo ( p = 0.0023, but the comparison was below the hierarchical break).

We observed a nominally significant association with 2 HLA alleles: HLA-A*23:01 (OR=1.04, p=2.3x10 -3 ) and HLA-C*06:02 (OR=1.04, p=1.5x10 -3 ).

Conditioning on this common variant rs3817928, the joint test of gene-by-current-smoking analysis for GPR126 remained nominally significant in the discovery ( p -value = 2.4E−03) and genome-wide significant in the replication studies ( p -value = 3.9E−09 in UK BiLEVE and p -value = 9.6E−17 in UK Biobank, Table 3 ).

In five of these six studies, p.E40K was associated with lower fasting glucose, and nominally significant association with fasting glucose was observed in meta-analysis of these six studies ( p = 0.0024, total n = 120,050).

Of 21 fatty-acid parameters quantified in Table 2 , 19 had Pearson log-linear correlations that were nominally significant at P <0.05, and 13 were highly significant at P <0.0024 (i.e. <0.05/21).

This difference was nominally significant ( P =2.6 × 10 −3 , two-tailed Fisher's exact test, OR=6.7, 95% CI=1.7–31.1) but did not withstand multiple testing correction for all 189 candidate genes.

All P -values were two-tailed; P < 0.05 was considered nominally significant, and P < 0.0026 (Bonferroni correction P = 0.05/19) was considered a significant association.

Using a sliding window of five consecutive SNPs, nominally significant haplotypic association (p = 0.0026) was identified in the region of PEPD at the SNPs rs10500265-rs6510383-rs7248389-rs7250833-rs2241380 (Table 3 ).

At RAD54L , conditional analysis suggested that the common GWAS variants rs12142240 (reported by ReproGen) and rs12073998 (the strongest common-variant association we found, which is in high linkage disequilibrium with rs12142240) were in high linkage disequilibrium with all of the other genome-wide significant associations at the locus, and rare missense rs28363218 remained nominally significant at p = 2.6 × 10 −3 , suggesting its independence ( Table S9 ).

The most strongly associated SNP (rs804279) was intergenic, approached genome-wide significance in the Stage 1 Discovery GWAS (A allele, OR=0.74, 0.66–0.83 95%CI, logistic regression P =1.4 × 10 −6 ), and was nominally significant in the Stage 2 Metabochip Replication (A allele, OR=0.82, 0.73–0.93 95%CI, logistic regression P =2.7 × 10 −3 ) for a sample-size weighted two-strata meta-analysis P meta =1.9 × 10 −8 .

Nominally significant effects were found in four gene sets causing inferior outcomes at posttreatment: intracellular signal transduction (large size CNVs: β = 0.204, P = 0.0027; clinically significant CNVs: β = 0.202, P = 0.0029), cell adhesion and trans-synaptic signaling (large size CNVs: β = 0.255, P = 0.0071; clinic

Although no CPG showed significant enrichment after FDR adjustment, BRCA1 showed the highest frequency of P/LP carriers in NB patients (N = 7, 1.05%) and yield a nominally significant enrichment (Firth's logistic regression P = 2.7 × 10 −3 , OR = 18.76) as well as BRCA2 (N = 4, 0.060%, Firth's logistic regression P = 0.032, OR = 11.21) ( Fig. 2 b, Table 2 , Table S11 ).

When we allowed for multiple testing, ten of the 17 nominally significant loci reached the required level of significance ( p < 2.8 × 10 −3 ).

The most nominally significant 2-locus haplotype associated with rectal cancer ( P = 0.0028; FDR q = 0.074) was across rs11722146 and rs4648110 (r 2 = 0.10) in which carrying two copies of the minor alleles A-A confers a ~50% increased risk, which is somewhat greater in effect than an OR of 1.2 when rs11722146 A allele was considered independently.

In sex-stratified analyses, cg06613262 was also the top site in male only models where we observed a nominally significant association between DNAm and prenatal perceived stress (% difference = 0.028% per one-unit increase in prenatal perceived stress, P -value = .0029) ( Supplementary Table 6 ).

Notably, differential analysis carried out in participants without a clinical diagnosis of dementia ( n = 562) showed nominally significant associations for these genes, but they did not pass multiple correction ( PWAR1 uncorrected p = 2.9 × 10 −3 , q = .16 and CTDSPL2 p = 2.2 × 10 −4 , q = .38).

Although we find some nominally significant changes for the targets of PRRX2 (p = 0.0029) and ARID3A (p = 0.0257), these genes actually have less overall amplification in the agiogenic subtype compared to the non-angiogenic subtype (t = −2.98 and t = −2.23 respectively).

Although the results did not survive Bonferroni correction, nominally significant enrichments were observed for platelet sensitization by low-density lipoprotein cholesterol ( p = 0.003), IL-7 signaling ( p = 0.004), glycerophospholipid biosynthesis ( p = 0.005), and viral messenger RNA synthesis ( p = 0.011) ( Figure 2 and Supplementary Table 5 ).

TBC1D1 gene, the top associated segment in autozygosity mapping, was nominally significant associated with time-to-spontaneous onset of delivery at the nominal level ( P -value = 0.003) in the gene burden analysis.

Age at diagnosis was the only variable with a nominally significant association with OS (HR = 1.03, 95% CI 1.01–1.04, p = 0.003; FDR = 0.057).

Among the eight other previously reported association signals, all were directionally consistent with our study, but only rs8105767 ( ZNF208 ) was nominally significant (P=0.003).

Nominally significant associations were observed in elderly participants (OR 1.68, 95% CI 1.20–2.37, p = 0.003), men (OR 1.40, 95% CI 1.06–1.86, p = 0.018), and patients with hypertension (OR 1.55, 95% CI 1.14–2.11, p = 0.005).

rs3818361 ( CR1 ) and rs3764650 ( ABCA7 ) both showed nominally significant differences compared with controls ( CR1 OR = 1.7 [1.20–2.41], P = .003, P GC = .004; ABCA7 OR = 1.83 [1.17–2.86], P = .009, P GC = .01).

11 , 12 Other investigators have determined that the −521 C>T and 120 bp tandem repeat (TR) polymorphisms in DRD4 are associated with nominally significant summary odds ratios (ORs) as risk factors for schizophrenia ( P =0.003 and 0.005, respectively). 11 However, despite a great deal of research, an association between DRD4 polymorphisms and schizophrenia risk remains debatable.