“nominally significant”

Significant or nominally significant reduction in symptoms was observed at Weeks 6 and 12 in both trials (Figure E5 [E-RS], Figure E6 [SGRQ]).

As evidenced by the eigenvector time series of PC1, the neural ensemble encoded a delay-discounted reward value (pointing toward –18°) in a stable manner for approximately 2 s after the presentation of the instruction cue and then rotated progressively toward a nominally significant pattern (pointing toward 44°) in which activity increased with longer delays to reward.

Indeed, fewer than half of the 32 SNPs in our panel are represented on any one high‐density SNP chip currently commercially available, although direct genotyping of a larger number of SNPs showing nominally significant association will be possible with the PsychChip (Illumina, San Diego, CA).

LDSC estimated positive genetic correlations between BIP and intake of fish ( r g = 0.24) and vegetables ( r g = 0.29), as well as between MD and fish intake ( r g = 0.25); however, the results were only nominally significant after correction for multiple testing ( Table S8 ).

In the full cohort, wine was only nominally significant (P β <0.05, P β ≥7.94×10 −4 ).

Finally, through permutation analyses, we showed that the load score amongst coding sites had an excess of nominally significant associations on many medical phenotypes.

A nominally significant relationship was observed between serum selenium levels and forearm bone mineral density.

The study successfully met its primary safety endpoint and demonstrated a 76-77% slower cognitive decline from baseline in the active treatment group compared to the sham group that was nominally significant ( 156 ).

In addition, several taxa were identified based on nominally significant IVW estimates with modest effect sizes; therefore, these associations should be interpreted as exploratory rather than definitive causal evidence.

Although most distortion effects are nominally significant and exceed the largest k ‐value we obtained from our null model based on Mendelian simulations (above), there are reasons to suspect other unmodeled sources of variation might be responsible rather than segregation distortion.

A nominally significant non‐linear association was observed only for the aMED score, with a greater rate of risk reduction beginning around a score of 3.5 ( p non‐linearity = 0.04; Figure S1 in supporting information); each one‐unit increase in the aMED and MIND scores was associated with a 5% and 3% lower risk of dementia in linear trend analyses, respectively.

Effect of genotype on basal gene expression We detected nominally significant genotype-dependent differences in expression of two genes in caudoputamen, one gene in nucleus accumbens, six genes in hypothalamus, and four genes in hippocampus.

Thus, the nominally significant bivariate correlations should be interpreted cautiously as preliminary descriptive evidence rather than confirmatory findings.

S5a), although power was sufficient to identify nominally significant associations (Additional file 1: Fig.

Results that were nominally significant in our AD‐adjusted model were predominantly in the direction of effect opposite of that hypothesized.

Results were stratified into significance tiers: highly significant (FDR < 0.05), nominally significant (FDR < 0.10), and exploratory (FDR < 0.25), given the nature of this biomarker discovery study.

[ 65 ] reported a nominally significant association in a Chinese Han population, whereas the results of Davis et al.

This is consistent with results from the study of the sex-specific genetic architecture of high-level human complex traits [ 26 ], but is in contrast to the observation of a negative relationship in a review of other multiple species, which found that traits with large mean phenotypic differences across the sexes had small or negative genetic correlations [ 16 ]. To test if there was common functionality in the 100 probes with the most nominally significant deviation from r G =1, we performed a gene ontology (GO) analysis using the DAVID functional annotation tool.

P ‐values larger than α but less than 0.05 were labelled as “nominally significant”.

However, these nominally significant differences did not remain significant after FDR correction.

Additionally, a p-value of less than 0.05 was considered nominally significant for all MR methods.

Most of the p-values for interaction between neighborhood groups and age and sex were not statistically significant, except for a nominally significant p-interaction between sex and neighborhood trajectories for all-cause mortality (0.004).

In the following sections, we discuss the biological relevance of these three metabolite networks (ME7, ME8, and ME11) that were FDR significant and also associated with MetS z-score in boys as primary findings, followed by a discussion of secondary findings comprising other results that were nominally significant at alpha = 0.05. 3.2.

We found 1136 CpGs associated to BMI (nominally significant), of which 729 (64.1%) show a significant P -value for CRP mediating the effect of BMI effects on DNA methylation, with 213 loci reaching Bonferroni significance ( Supplementary Data 2 , 10 ).

Maternal age also showed a nominally significant effect on SPQ-B scores, but not on NEO-FFI scores.