“nominally significant”

were able to identify methylated regions of the H19 and TEAD3 genes in the same dataset, with nominally significant P -value and great beta-value differences when comparing high-exposed subjects with lower-exposed ones [ 41 ].

A two-tailed P < 0.05 was considered nominally significant.

Although several nominally significant associations were observed, none remained statistically significant after correction for multiple testing. 4.

Associations to HLA-DRB1*01∶01 and *07∶01 were reduced, but still nominally significant, whereas the associations detected at the *13∶01 and *04∶01 alleles were non-significant.

We selected genes and methylation sites that showed nominally significant differences between RES and NRES, at the p-value less than or equal to 0.05 and absolute average beta value difference greater than or equal to 0.025, for gene expression and methylation, respectively.

3 b), whereas their “complementary” associations (CKD-EEAA and eGFR-PhenoAA) were nominally significant (Additional file 2 : Fig.

In our sample, there were nominally significant differences between groups for cortical thickness and surface area in parietal and frontal brain regions; however these observations should be confirmed in independent studies before we can assess their role in the etiology of genetic risk for SCZ.

The associations remained nominally significant after adjustment for major vascular risk factors.

SNP rs9990333 showed a nominally significant association with presence of plaque that was directionally consistent [OR 1.32 (95 % CI 1.03; 1.68)], but this SNP showed inconsistent, nonsignificant effects on other NIMA.

Results The C allele was found to be more common in case subjects than in control subjects (cases, 0.59; controls, 0.54) corresponding to a nominally significant increase in breast cancer risk to heterozygotes and CC homozygotes (odds ratio 1.51, 95% confidence interval 1.01–2.25) in the dominant inheritance model.

As shown in online supplemental table S4 , the effect allele frequencies in the in-house controls and ORs were generally comparable with those obtained by using the 60KJPN as controls ( online supplemental table S2 ), except that the low frequency allele rs9290877C at LPP showed higher ORs and nominally significant association when the in-house controls were used.

Despite the high negative correlation between HDL and very low-density lipoprotein (VLDL) or low-density lipoprotein (LDL) measures, only a few associations with LDL or VLDL measures were found nominally significant and none remained significant after correction for multiple comparisons.

Of the 32 initially enriched pathways in MDD with hyperphagia, 22 were still nominally significant after BMI adjustment.

However, nominally significant metabolites identified in the present study require follow-up in larger settings with more statistical power for subgroup analysis by tumor stage, tumor site, or BMI. 4.

For the sliding windows, 2351 tests were conducted and 314 were found to be nominally significant (0.0021–0.05, not accounting for multiple testing).

Nominally significant associations with BMI were observed for 28 SNPs.

The longer list of candidate biomarkers includes the top biomarkers from discovery step ( ≥ 90% of scores, n = 28), the top biomarkers from the prioritization step (CFG score ≥ 8, n = 32), and the nominally significant biomarkers after the validation step ( n = 5), for a total of n = 65 probesets ( n = 60 genes).

While other connections had nominally significant differences, given the high dimensionality of the connectomes, they did not survive an FDR correction.

We next evaluated the probability of true association with cancer risk for the nominally significant variants through calculating the FPRP value.

WHR and two skin fold measures (TrS and SbS) of cluster 2 also showed nominally significant associations with some of these markers, significance of which were not supported by the permutation test.

Finally, we performed a conditional logistic regression analysis for testing if the effects of the two nominally significant SNPs (rs17213159 and rs1023073) showed independent effects.

Methylation level difference of gene segments and CpG sites between gliotic and florid PDR group Although no statistically significant differences were detected at the whole-promoter level for the 16 target genes between the two PDR subtypes, exploratory analysis of finer-resolution regions revealed several nominally significant differences at the gene segment and individual CpG site levels.

There were 3321 nominally significant differentially methylated CpGs in F0 sperm identified via WGBS with select methylation changes validated via bisulfite pyrosequencing.

There were several nominally significant differences in neuroimaging and blood biomarkers differed based on participants’ gender, including water-referenced choline in the basal ganglia and IL-1β and YKL-40 in serum (though these associations did not survive FDR correction; S4 Fig ).

In the contrary, all-cause mortality was significantly lower under alirocumab, however, this finding is considered nominally significant as to the hierarchical testing with previous non-significant endpoints.