“nominally significant”

Furthermore, we tested multiple phenotypes and the associations for CAD and systolic blood pressure were only nominally significant (<0.05).

The analysis of Belgian CD trios revealed only nominally significant associations with the major alleles (i.e. allele frequency in controls >50%) of four SNPs, three of which are located in the haplotype block encompassing the region covering the MEFV promoter to intron 2 and its 5′ flanking region (rs182674( A ): p = 0.029; rs224217( G ): p = 0.052; rs224231( G ); p = 0.039; rs6501170( T ): p = 0.016; the risk nucleotides are indicated in brackets) ( Figure 2A , Table S1 ).

We identified a nominally significant negative interaction between these genetic risk factors, implying that the impact of PRS-IQ on ASD risk is attenuated in subjects with a high burden of CNVs, irrespective of their level of cognitive ability.

Thus, a Benjamini–Hochberg false discovery rate (FDR) ≤ 0.05 was considered significant and FDR ≤ 0.10 was considered nominally significant.

Due to the larger number of SNPs used in this analysis, the standard error of this intercept is smaller, leading to a nominally significant p -value for directional pleiotropy ( Table S5B ).

The overall omnibus p-value for surgical approach was p = 0.125 (non-significant); nominally significant individual contrasts for specific approach categories reflect sparse-data instability in the reference group and should not be interpreted as independent effects.

We used these GWAS in a subsequent tissue-specific network-wide association study (NetWAS), which applied nominally significant associations in the initial GWAS to identify disease relevant patterns in a functional network for the hippocampus.

Results Three SNPs - rs2278493 in HK3, rs2234693 in ESR1 and rs12611091 in BRSK1 - showed nominally significant association with POF.

Conversely, findings with P < 0.05 but P FDR > 0.05 were categorized as nominally significant.

In order to identify novel associated loci, we considered the following steps (Figure 2 ): (1) we identified all loci that were statistically significant in the multi‐phenotype analysis ( p ‐value multivariate <1.85 x 10 −9 ) (significant loci); (2) among these, we identified all loci with a lead variant that was at least nominally significant for two of the individual datasets used in each combination of phenotypes (lead variant p ‐value univariate <.005) 30 , 31 , 32 (significant loci driven by more than one phenotype); (3) among the loci from step 2, we then narrowed it down to loci that were new for at least one of the ph

Interestingly, while the sample sizes were much smaller for Asian individuals than for H/L and AA individuals, the transethnic meta-analysis of the PROX1 index (rs340874) was only nominally significant and directionally consistent in the Asian samples.

Tam 2.0 tool overrepresentation analysis [ 33 , 34 ] was also performed with all nominally significant DE miRNAs as inputs and the settings of all curated miRNAs as background, limited to a miRNA set size of two, including up- and down-regulated miRNA sets. 2.5.

For plasma pTau217, post-hoc analysis of the change from baseline with ACI-35.030 treatment, when compared to the corresponding change from baseline for the pooled placebo group, was nominally significant at weeks 31, 36, and 74 for the 900 μg dose and 10, 15, and 36 for the 1800 μg dose ( Fig. 3 and Table 6 ).

The PRS for triglycerides had a nominally significant association that was not significant after Bonferroni correction.

In AUD patients, our initial analysis revealed several nominally significant associations (Table 5 ).

Conversely, the LPA locus showed only a nominally significant association with baseline LDL-C in Oni-Orisan et al.’s paper 6 but was clearly associated with baseline LDL-C in the IMPROVE-IT dataset.

Meanwhile P < 0.05 was regarded as nominally significant, suggesting potential causality between menstruation and CVD ( 36 ). 3.

Associations with a nominal P-value (P_HKSJ) < 0.05 but P_FDR ≥0.05 were considered nominally significant association.

Conclusion: Intakes of fiber, whole grain, fruits, and meat showed nominally significant associations with relative abundance of several gut bacterial genera.

While DAPA‐HF trial showed a nominally significant reduction in cardiovascular and all‐cause mortality, EMPEROR‐Reduced and SOLOIST‐WHF did not.

We have highlighted the nominally significant results obtained given the exploratory nature of our analysis.

We also observed nominally significant sex‐specific differences in the risk for HF (which is likely due to the downstream effects of CAD diagnosis), which remained nominally significant in the sensitivity analyses using sex‐specific weighted scores.

P values less than 0.007 were considered nominally significant in the analysis of the 7 SNPs.

Values of p < 0.05 were considered nominally significant; no multiplicity adjustment was conducted.

The absence of significant findings in this study may be due to primary neurometabolic disturbances showing rapid resolution ( Giza and Hovda, 2014 ), as we identified a nominally significant effect of days post-injury within the acute phase of injury.