“nominally significant”

Non-synonymous variants identified by deep-sequencing of 10 identified genes (GWAS), and 11 identified by association with innate immunity, Table 1 showed TLR4 was associated with BD, while rare nucleotide-binding oligomerization domain-2 ( NOD2 ) variants were nominally significant.

Nominally significant REST to C- and F-WAIT reductions occurred in DMN-related regions, including precuneus, superior parietal lobule, postcentral gyrus and medial frontal gyrus (F-WAIT: pseudo t = 5.07, corrected p = 0.20; C-WAIT: pseudo t = 6.16, corrected p = 0.15) but these were not significant when p values were adjusted for multiple testing.

At the replication stage, P replication < 0.05 and consistent effect direction of the interaction term with the discovery cohort were considered as nominally significant.

FADS1 showed the most consistent evidence for divergent regulation between agriculturalists, pastoralists, and hunter-gatherers, with nominally significant divergence for 17 tissue models ( supplementary table 2 , Supplementary Material online ).

The nominally significant predictor for HDL cholesterol in nonaggressive and aggressive participants was the total value of the PANSS scores.

In addition, we identified a total of 93 FDR significant DMRs, of which 14 were nominally significant in the ALSPAC study.

Nominally significant findings ( P uncorrected < 0.05) with 0.05 ≤ P FDR < 0.1 were also reported as exploratory. 2.4.2 Correlation with rumination traits We explored associations between metrics showing significant differences in the rumination-distraction comparison and rumination traits.

For ANM we found weak evidence of reverse causation for PNP and TXNDC15, with only one of the four MR methods obtaining estimates with nominally significant p -values (Supplementary Data 16 ).

All tests were two-sided, and P < 0.05 was considered nominally significant.

We observed that 7 of these pairs had a nominally significant association p -value p< =0.05 in CAMP.

When the P.FDR exceeds 0.05 but the original p value is below 0.05, it is classified as a nominally significant association.

In men, with only two twin pairs, none of the gene expressions survived correction for multiple comparisons; however, several genes, including LHX1 , showed nominally significant difference in the comparison between ST vs. unaffected twins (Fig. 2b ).

Using 109 selected tagging SNPs localized within TP63 with a minor allele frequency >0.01, they found nominally significant associations between BEEC and six SNPs and four haplotype blocks including or near these significant SNPs; however, none of these results remained significant after correction for multiple testing.

15 , 20 Meanwhile, in patients previously treated with ruxolitinib (SIMPLIFY-2), there was a nominally significant difference in favor of momelotinib versus best available therapy (88.5% ruxolitinib) in MPN-SAF TSS. 16 Because the threshold for superiority for the primary end point (splenic response rate [SRR]) was not met, symptoms could not be formally assessed.

Also, we regarded p < 0.05 as nominally significant.

A p -value less than 0.05, was considered nominally significant.

Moreover, when the difference in PTI (healthy side minus affected side) for each plantar region was calculated and compared between the two groups, nominally significant differences were observed for the lateral sole (mean difference: 1.16 N·s/cm2, 95% CI: 0.08 to 2.24, Cohen’s d = 0.958) and entire sole (mean difference: 0.53 N·s/cm2, 95% CI: -0.11 to 1.17, Cohen’s d = 0.718) before correction for multiple comparisons ( P = 0.037 and P = 0.048, respectively; Table 5 ; Fig. 5 ).

MR Results with the P FDR < 0.1 were considered significant; whereas results with p < 0.05 but P FDR > 0.1 were considered as nominally significant.

The autophagy enrichment was nominally significant in the primary analysis but did not survive Benjamini-Hochberg false-discovery rate correction across the ten tested pathways (false discovery rate (FDR)-adjusted p = 0.41979); the findings should therefore be considered hypothesis-generating. autophagy cellular maintenance genetic architecture hyp

An alternative and commonly applied strategy for discriminating between real and false disease loci identified through association studies is to replicate nominally significant results in independent datasets, thereby reducing type II error as all significant results are followed up.

The marker pair on chromosomes 1p and 2q, which gave a Z score of -4.08 in Mexicans, also had a nominally significant Z score in Puerto Ricans (-2.40), while the pair on chromosomes 1p and 17p (Z score of -4.09 in Mexicans) also had a nominally significant Z score in Puerto Ricans, but in the opposite direction (Z = +2.42).

Median-based and inverse-variance weighted approaches detected nominally significant causal association between periodontitis-linked SNPs and SBP or PP ( Table 1 ).

Bonferroni correction was applied to account for the multiple testing (a total of 28 FAs), where p -value < 0.002 (0.05/28) was regarded as statistically significant and p -value < 0.05 was regarded as nominally significant [ 29 ].

An FDR < 0.05 is considered nominally significant.

28 An MYOC exon 3 variant (rs74315329; effect allele: A) was associated with a 1.63 mm Hg (95% confidence interval [CI] = 0.64 to 2.64) and 2.67 mm Hg (95% CI = 1.7 to 3.60) increased IOP in participants <51 years old and ≥63 years old, respectively, resulting in a nominally significant age-gene interaction ( P interaction = 0.05; Supplementary Table S10 ).