“nominally significant”

All results were considered nominally significant after correction for multiple testing.

However, it is also important to note that certain SF-36 outcomes that were nominally significant before multiplicity control, such as the SF-36 MH and SF-36 Vitality MCID, did not remain significant after FDR correction.

In the DISCOVERY trial, genotypes of 2 SNP s in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses ( TT vs CC / CT in c.393C>T: HR 1.42 [ CI 1.11‐1.80], P =0.005; TT vs CC / CT in c.2273C>T: HR 1.57 [ CI 1.18‐2.09], P =0.002).

We arbitrarily selected p<5.0×10 −4 as nominally significant since it corresponds to a corrected p-value of 0.05 after correction for 100 independent gene regions and the 508 SNPs analyzed in the study fell into ∼100 independent linkage disequilibrium blocks.

All the remaining loci with the exception of the FAM30A locus showed at least a nominally significant parent of origin P -value (<0.05) between the SNP and methylation at the relevant CpG site at all three time points ( Tables 1 and 2 ).

Meta-analysis provided robust evidence for IL27RA (OR = 0.97, 95% CI: 0.95–0.98, P = 1.0×10-6) and TIE1 (OR = 1.14, 95% CI: 1.07–1.21, P = 4.8×10−5), while IL17RD was nominally significant.

This association of the SNP × CP interaction with MetS remained nominally significant in multiple logistic regression analysis after adjustment for either the number of MetS components or MetS components excluding obesity.

Nominally significant mean improvements were seen in both patient subgroups for other key secondary endpoints, including reductions in total cholesterol, LDL-cholesterol, body weight, and BMI ( Table 3 ).

( 2009 ) noted a nominally significant association between AVPR1B and the empathy quotient (EQ) also in a non-clinical sample.

For CER24:0 and CER22:0/16:0, we saw the same pattern, but associations were only nominally significant.

In the analysis by individual IGA score, the number of patients in each subgroup was relatively small; nevertheless, the differences observed between dupilumab and placebo were nominally significant.

Subsequently, an enrichment analysis was performed among these variants to determine whether an excess of nominally significant values was observed.

However, six out of these nine SNPs were nominally significant in the current UK Biobank sex-stratified COVID-19 GWASs, including these three SNPs (rs17763742, rs115679256, and rs35477280) located in the 3p21.31 region.

A raw p value <0.05 was considered nominally significant, which was further subjected to a Bonferroni correction to account for multiple testing in this study, where a significance level of 0.05/N (N = 198, i.e., the total number of the tested CNPs) was used as a significance threshold for a test ( p = 2.53×10 −4 ).

These PLCG2 expression differences were largely driven by the significant overexpression detected in ADAD brains across all cell types except microglia, which was nominally significant (Supplementary Dataset 10 ).

For the recent study of ALM in middle-aged and older UKB participants, all 182 lead SNPs were nominally significant in the present study, and up to 168 (92.3%) were significant at the GWS level.

R s12126142 in RA and rs6679677 in SLE were the only SNPs with nominally significant associations with ASD ( Supplementary Tables 1 and 2 ). 2) MR results There was no support for an association between RA and SLE using the IVW technique, which showed no relationship (beta=−0.077, SE=0.041, p=0.062; beta=0.014, SE=0.021, p=0.493) ( Table 1 , Figures 1 and 2 ).

SNP and Gene-Based Functional Analysis of Most Significant GWAS Hits and Their Link to Neurological Traits and Pathologies The analysis with the most nominally significant SNPs from all five linear regressions retrieved a total of 30 candidates, all with functional relevance in brain tissues, as suggested by expression and epigenetic data.

Given the large number of stratified analyses performed across multiple demographic and geographic strata, the familywise error rate is inflated and some nominally significant subgroup results may represent Type I error; accordingly, effect sizes and 95% confidence intervals are emphasized alongside p -values for subgroup comparisons, and borderline findings are interpreted with appropriate caution. 2.5.3.

A nominally significant larger effect of the GRS was observed among participants with baseline HbA 1c levels above the median as compared with those with values below the median ( P for interaction = 0.02).

After including incident silent MI events, the significant increase in MI was no longer nominally significant.

None of the P -value for the univariate test was nominally significant for that variant ( P -values are 0.44, 0.10, 0.11 and 0.52 for insulin resistance, fasting insulin, insulin secretion and fasting proinsulin, respectively).

6 SNPs from RRM2B and UBR5 were added to this list because they are both members of GO:6281 “DNA Repair” (which, although nominally significant in GeM, did not reach q < 0.05 and was therefore not used to create the pathway cluster), both lie within a genome‐wide significant association peak in GeM‐HD, and both have significant gene‐wide p values (see Table S5 of the GeM‐HD article). 6 For each gene, the most significant SNP was selected, along with a small number of proxy SNPs in close LD ( r 2 > 0.8) with the most significant SNP that also showed association in GeM‐HD.

However, while multiple nominally significant cis -eQTLs were present, nearly half of all loci had no evidence of cis -eQTLs in the sample sets used.

In addition, we detected a nominally significant positive correlation between cg05649751 methylation and the expression of one of its cis -genes, SH2B3 , which encodes a critical negative regulatory protein in cytokine signaling and was reported to be associated with the risk of lung, colorectal, and breast cancer 32 .